ENSG00000164167

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000515311 ENSG00000164167 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM6 protein_coding nonsense_mediated_decay 76.8935 81.79801 88.31502 6.541112 3.862726 0.1105799 55.670626 57.20755 62.273410 4.848827 1.45614703 0.1223902 0.72663750 0.6994667 0.7063667 0.0069 9.519783e-01 1.205188e-08    
ENST00000649747 ENSG00000164167 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM6 protein_coding protein_coding 76.8935 81.79801 88.31502 6.541112 3.862726 0.1105799 11.314853 12.00763 13.385967 2.335568 1.94894754 0.1566466 0.14500833 0.1467000 0.1504000 0.0037 9.631334e-01 1.205188e-08    
MSTRG.25549.8 ENSG00000164167 HEK293_OSMI2_2hA HEK293_TMG_2hB LSM6 protein_coding   76.8935 81.79801 88.31502 6.541112 3.862726 0.1105799 6.674769 11.01035 6.026638 1.377352 0.09783141 -0.8683526 0.08872917 0.1338000 0.0684000 -0.0654 1.205188e-08 1.205188e-08    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164167 E001 1.5123699 0.0088993123 3.717527e-02 8.580444e-02 4 146175691 146175702 12 + 0.572 0.209 -2.141
ENSG00000164167 E002 3.9824552 0.0631957735 3.475405e-02 8.117434e-02 4 146175703 146175717 15 + 0.875 0.499 -1.592
ENSG00000164167 E003 12.5302376 0.0013767824 3.659639e-02 8.470672e-02 4 146175718 146175726 9 + 1.232 1.038 -0.696
ENSG00000164167 E004 13.1161252 0.0013439976 2.275642e-02 5.724368e-02 4 146175727 146175727 1 + 1.257 1.050 -0.741
ENSG00000164167 E005 14.0017196 0.0014323886 4.344050e-02 9.736376e-02 4 146175728 146175728 1 + 1.273 1.095 -0.633
ENSG00000164167 E006 80.0614534 0.0110053205 1.005642e-01 1.913137e-01 4 146175729 146175747 19 + 1.964 1.865 -0.333
ENSG00000164167 E007 224.1087301 0.0002884758 1.566091e-05 9.952076e-05 4 146175748 146175769 22 + 2.407 2.304 -0.344
ENSG00000164167 E008 369.2592677 0.0002799599 5.047616e-02 1.100106e-01 4 146175770 146175811 42 + 2.587 2.550 -0.126
ENSG00000164167 E009 5.9648054 0.0027771486 6.520212e-01 7.627777e-01 4 146175812 146176167 356 + 0.875 0.818 -0.219
ENSG00000164167 E010 25.2703580 0.0012522163 8.951664e-01 9.369949e-01 4 146176168 146176437 270 + 1.425 1.416 -0.031
ENSG00000164167 E011 0.6696487 0.0294929866 2.769058e-01 4.163972e-01 4 146176438 146176686 249 + 0.307 0.117 -1.723
ENSG00000164167 E012 33.2337804 0.0198651585 9.205199e-01 9.538355e-01 4 146182906 146182911 6 + 1.524 1.527 0.009
ENSG00000164167 E013 381.9239842 0.0001635287 8.381103e-01 8.987775e-01 4 146182912 146182922 11 + 2.580 2.583 0.010
ENSG00000164167 E014 614.7595678 0.0001064359 2.532972e-01 3.898006e-01 4 146182923 146183015 93 + 2.797 2.782 -0.052
ENSG00000164167 E015 2.5495789 0.0059041019 4.912407e-01 6.285428e-01 4 146183016 146183646 631 + 0.610 0.501 -0.504
ENSG00000164167 E016 614.6507302 0.0001859124 8.328014e-01 8.952501e-01 4 146187274 146187387 114 + 2.790 2.786 -0.012
ENSG00000164167 E017 1.8059350 0.0081069096 2.936354e-01 4.346951e-01 4 146187388 146187551 164 + 0.530 0.350 -0.947
ENSG00000164167 E018 433.2449158 0.0002132229 4.067888e-07 3.662259e-06 4 146189622 146189781 160 + 2.587 2.672 0.285
ENSG00000164167 E019 155.4816732 0.0012537686 1.517331e-15 5.603387e-14 4 146189782 146190080 299 + 2.025 2.291 0.890
ENSG00000164167 E020 19.8463174 0.0511113235 3.861338e-02 8.847492e-02 4 146190081 146191535 1455 + 1.447 1.200 -0.861
ENSG00000164167 E021 1.8275937 0.4417886246 1.549233e-01 2.683136e-01 4 146199939 146199942 4 + 0.643 0.211 -2.442
ENSG00000164167 E022 3.1897078 0.1180207559 6.839319e-03 2.080893e-02 4 146199943 146200019 77 + 0.853 0.286 -2.716
ENSG00000164167 E023 0.1515154 0.0433595674 4.546975e-01   4 146206157 146206191 35 + 0.128 0.000 -8.749