ENSG00000164163

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296577 ENSG00000164163 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCE1 protein_coding protein_coding 69.6225 19.07526 121.606 1.223998 3.406395 2.671802 39.6190782 13.350971 67.60952 0.2556502 2.618434 2.339415 0.63395833 0.70423333 0.5557000 -0.14853333 1.154451e-02 8.217236e-57 FALSE TRUE
ENST00000502586 ENSG00000164163 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCE1 protein_coding protein_coding 69.6225 19.07526 121.606 1.223998 3.406395 2.671802 15.3782064 0.000000 30.60282 0.0000000 1.009757 11.579920 0.13042083 0.00000000 0.2520333 0.25203333 8.217236e-57 8.217236e-57 FALSE FALSE
ENST00000502803 ENSG00000164163 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCE1 protein_coding processed_transcript 69.6225 19.07526 121.606 1.223998 3.406395 2.671802 5.9386720 0.000000 10.58551 0.0000000 0.905911 10.049237 0.04798333 0.00000000 0.0868000 0.08680000 1.085704e-27 8.217236e-57 FALSE FALSE
ENST00000504683 ENSG00000164163 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCE1 protein_coding retained_intron 69.6225 19.07526 121.606 1.223998 3.406395 2.671802 0.2757414 1.814740 0.00000 1.1630466 0.000000 -7.511547 0.01445417 0.09226667 0.0000000 -0.09226667 4.699448e-02 8.217236e-57 FALSE TRUE
MSTRG.25580.5 ENSG00000164163 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCE1 protein_coding   69.6225 19.07526 121.606 1.223998 3.406395 2.671802 0.7172433 2.268444 0.00000 0.7697775 0.000000 -7.831905 0.03967083 0.11913333 0.0000000 -0.11913333 4.018220e-13 8.217236e-57 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164163 E001 0.9264823 0.0949628645 1.000000e+00 1.000000e+00 4 145098276 145098276 1 + 0.226 0.250 0.189
ENSG00000164163 E002 1.0779977 0.1124888344 8.703248e-01 9.205951e-01 4 145098277 145098278 2 + 0.260 0.250 -0.075
ENSG00000164163 E003 2.6164926 0.0057989398 5.373646e-01 6.689342e-01 4 145098279 145098287 9 + 0.484 0.407 -0.396
ENSG00000164163 E004 28.0108690 0.0807253728 2.224090e-01 3.532717e-01 4 145098288 145098310 23 + 1.360 1.257 -0.363
ENSG00000164163 E005 42.0025421 0.0675201762 6.562620e-02 1.360875e-01 4 145098311 145098313 3 + 1.541 1.359 -0.628
ENSG00000164163 E006 85.7761558 0.0165197355 3.056383e-04 1.402399e-03 4 145098314 145098330 17 + 1.851 1.617 -0.792
ENSG00000164163 E007 303.1019828 0.0024578556 1.825943e-10 3.079766e-09 4 145098331 145098419 89 + 2.389 2.218 -0.570
ENSG00000164163 E008 178.7884235 0.0002889105 4.829219e-14 1.436685e-12 4 145104386 145104388 3 + 2.168 1.941 -0.761
ENSG00000164163 E009 464.2527076 0.0009442207 3.225624e-18 1.667808e-16 4 145104389 145104515 127 + 2.573 2.405 -0.562
ENSG00000164163 E010 391.2536011 0.0012989931 6.512853e-10 1.000438e-08 4 145105605 145105690 86 + 2.491 2.378 -0.379
ENSG00000164163 E011 209.4485627 0.0001937071 7.160539e-05 3.879558e-04 4 145108015 145108026 12 + 2.214 2.153 -0.201
ENSG00000164163 E012 382.2120696 0.0001400762 1.092880e-15 4.103923e-14 4 145108027 145108112 86 + 2.484 2.350 -0.446
ENSG00000164163 E013 469.5152380 0.0001288651 3.955023e-19 2.287141e-17 4 145109132 145109249 118 + 2.574 2.439 -0.450
ENSG00000164163 E014 443.2942210 0.0001228908 3.907079e-14 1.177325e-12 4 145110103 145110240 138 + 2.545 2.440 -0.349
ENSG00000164163 E015 366.7046581 0.0002198042 1.927226e-07 1.852678e-06 4 145110375 145110444 70 + 2.457 2.396 -0.202
ENSG00000164163 E016 327.4716128 0.0001362262 3.843579e-04 1.714232e-03 4 145110968 145111064 97 + 2.401 2.381 -0.067
ENSG00000164163 E017 309.1699773 0.0001617716 2.455247e-03 8.629511e-03 4 145112239 145112328 90 + 2.373 2.365 -0.028
ENSG00000164163 E018 350.9222791 0.0001604733 5.059527e-03 1.609295e-02 4 145117293 145117414 122 + 2.426 2.429 0.008
ENSG00000164163 E019 1.1749829 0.2201278120 5.243130e-01 6.578687e-01 4 145117415 145117415 1 + 0.225 0.415 1.233
ENSG00000164163 E020 235.0635448 0.0034545560 1.447479e-01 2.544876e-01 4 145119932 145119967 36 + 2.252 2.263 0.040
ENSG00000164163 E021 537.8948680 0.0041968722 2.367687e-01 3.704494e-01 4 145119968 145120153 186 + 2.607 2.636 0.098
ENSG00000164163 E022 4.6639371 0.0034128230 7.768001e-02 1.557341e-01 4 145121010 145121033 24 + 0.695 0.407 -1.348
ENSG00000164163 E023 12.6945821 0.0014036872 1.983158e-02 5.113071e-02 4 145121034 145121173 140 + 1.061 0.809 -0.949
ENSG00000164163 E024 373.2593880 0.0024499651 4.090944e-01 5.527072e-01 4 145121174 145121233 60 + 2.445 2.489 0.148
ENSG00000164163 E025 10.6486597 0.0201257926 4.107326e-01 5.543274e-01 4 145121234 145121319 86 + 0.963 0.904 -0.223
ENSG00000164163 E026 7.2380463 0.0248510783 1.171112e-01 2.158249e-01 4 145121320 145121332 13 + 0.837 0.615 -0.910
ENSG00000164163 E027 224.8755084 0.0044659033 7.797603e-01 8.584269e-01 4 145121333 145121335 3 + 2.222 2.282 0.201
ENSG00000164163 E028 352.1802916 0.0001508083 3.641733e-01 5.085434e-01 4 145121336 145121391 56 + 2.410 2.505 0.316
ENSG00000164163 E029 2.4055547 0.0061903209 8.736156e-01 9.227652e-01 4 145121392 145121603 212 + 0.443 0.522 0.394
ENSG00000164163 E030 2.5946209 0.0064777271 9.642483e-01 9.814666e-01 4 145121604 145121813 210 + 0.464 0.522 0.287
ENSG00000164163 E031 15.4541768 0.0111708947 6.982505e-01 7.982612e-01 4 145121814 145122868 1055 + 1.104 1.127 0.082
ENSG00000164163 E032 3.2578237 0.0562634845 8.619767e-02 1.693154e-01 4 145122869 145123020 152 + 0.443 0.811 1.625
ENSG00000164163 E033 420.8818065 0.0001286334 5.027158e-01 6.387310e-01 4 145123021 145123131 111 + 2.489 2.576 0.293
ENSG00000164163 E034 517.5710041 0.0010176163 1.122613e-01 2.088454e-01 4 145123215 145123357 143 + 2.573 2.686 0.376
ENSG00000164163 E035 2.9041082 0.0435598000 8.827636e-01 9.289650e-01 4 145123358 145123477 120 + 0.503 0.522 0.090
ENSG00000164163 E036 442.8596590 0.0004359277 2.350231e-04 1.112777e-03 4 145123478 145123600 123 + 2.496 2.652 0.520
ENSG00000164163 E037 1.2973666 0.0104782060 5.813185e-01 7.058604e-01 4 145123601 145123931 331 + 0.260 0.407 0.926
ENSG00000164163 E038 376.9257841 0.0001360328 5.470854e-06 3.860100e-05 4 145124990 145125101 112 + 2.422 2.596 0.583
ENSG00000164163 E039 1942.6025410 0.0066478339 6.760225e-16 2.613149e-14 4 145127526 145129524 1999 + 3.087 3.428 1.132