ENSG00000164151

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296564 ENSG00000164151 HEK293_OSMI2_2hA HEK293_TMG_2hB ICE1 protein_coding protein_coding 11.28152 3.267164 18.59821 0.1684291 0.3239499 2.505419 8.8163504 1.110889 16.8885324 0.63276614 0.34253205 3.914183 0.6448583 0.3251 0.90800000 0.58290000 1.118835e-01 7.82137e-08 FALSE TRUE
ENST00000505464 ENSG00000164151 HEK293_OSMI2_2hA HEK293_TMG_2hB ICE1 protein_coding retained_intron 11.28152 3.267164 18.59821 0.1684291 0.3239499 2.505419 0.7733103 0.294502 1.2676272 0.09048908 0.05675225 2.068943 0.0743125 0.0926 0.06816667 -0.02443333 7.336571e-01 7.82137e-08 FALSE FALSE
MSTRG.25907.8 ENSG00000164151 HEK293_OSMI2_2hA HEK293_TMG_2hB ICE1 protein_coding   11.28152 3.267164 18.59821 0.1684291 0.3239499 2.505419 1.5715992 1.732678 0.2992827 0.33330105 0.14013208 -2.494308 0.2658000 0.5383 0.01613333 -0.52216667 7.821370e-08 7.82137e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164151 E001 0.0000000       5 5420664 5420692 29 +      
ENSG00000164151 E002 6.2257291 0.0027090743 3.016676e-04 1.386329e-03 5 5422677 5422730 54 + 0.832 0.001 -12.292
ENSG00000164151 E003 9.3270601 0.0017818769 7.147696e-06 4.910820e-05 5 5422731 5422741 11 + 0.986 0.000 -14.151
ENSG00000164151 E004 11.8359453 0.0014453300 9.300754e-06 6.226809e-05 5 5422742 5422766 25 + 1.075 0.248 -3.825
ENSG00000164151 E005 17.5789123 0.0010304442 2.579109e-06 1.959512e-05 5 5422767 5422856 90 + 1.227 0.519 -2.782
ENSG00000164151 E006 25.0187984 0.0007307041 4.606355e-07 4.103160e-06 5 5422857 5422999 143 + 1.368 0.749 -2.276
ENSG00000164151 E007 21.7997551 0.0092990775 3.430627e-05 2.010773e-04 5 5436418 5436476 59 + 1.308 0.749 -2.066
ENSG00000164151 E008 21.3309276 0.0159672784 5.760656e-06 4.044093e-05 5 5437080 5437114 35 + 1.305 0.610 -2.640
ENSG00000164151 E009 17.2738508 0.0029339528 4.277716e-02 9.613977e-02 5 5437115 5437836 722 + 1.109 1.321 0.752
ENSG00000164151 E010 20.2129109 0.0008855459 1.701379e-07 1.653353e-06 5 5439895 5439913 19 + 1.286 0.519 -2.992
ENSG00000164151 E011 40.3567232 0.0006378829 8.613797e-12 1.813175e-10 5 5441112 5441223 112 + 1.571 0.854 -2.560
ENSG00000164151 E012 40.9913197 0.0005305481 1.383895e-08 1.662057e-07 5 5443168 5443244 77 + 1.568 1.041 -1.849
ENSG00000164151 E013 35.1829989 0.0005876270 4.566880e-07 4.070485e-06 5 5444289 5444326 38 + 1.502 1.009 -1.737
ENSG00000164151 E014 42.0495667 0.0005323227 8.721658e-07 7.336620e-06 5 5447427 5447509 83 + 1.571 1.148 -1.473
ENSG00000164151 E015 35.7789375 0.0015404405 3.833675e-05 2.219812e-04 5 5447721 5447760 40 + 1.500 1.124 -1.315
ENSG00000164151 E016 34.9764373 0.0031641046 1.236650e-05 8.042612e-05 5 5447841 5447897 57 + 1.496 1.070 -1.495
ENSG00000164151 E017 0.5964967 0.0234707735 6.150214e-01 7.333826e-01 5 5453116 5453212 97 + 0.150 0.247 0.891
ENSG00000164151 E018 41.0807773 0.0045641076 9.947240e-08 1.010171e-06 5 5454552 5454638 87 + 1.569 1.041 -1.852
ENSG00000164151 E019 103.5328771 0.0006171378 1.952319e-21 1.470620e-19 5 5457332 5457741 410 + 1.966 1.367 -2.035
ENSG00000164151 E020 572.9512365 0.0069487698 3.152909e-15 1.117719e-13 5 5460436 5462760 2325 + 2.683 2.379 -1.013
ENSG00000164151 E021 676.4721778 0.0012604186 4.207742e-02 9.486988e-02 5 5462761 5465226 2466 + 2.718 2.693 -0.084
ENSG00000164151 E022 102.5500188 0.0003465481 4.642456e-07 4.133375e-06 5 5466334 5466502 169 + 1.851 2.074 0.750
ENSG00000164151 E023 97.5729970 0.0015487897 2.148078e-05 1.321986e-04 5 5468828 5468988 161 + 1.831 2.040 0.703
ENSG00000164151 E024 59.3484386 0.0004465201 1.509824e-05 9.632314e-05 5 5473558 5473611 54 + 1.608 1.856 0.838
ENSG00000164151 E025 92.1503781 0.0002878534 5.233452e-09 6.804350e-08 5 5473612 5473748 137 + 1.792 2.057 0.891
ENSG00000164151 E026 96.4404689 0.0002875269 2.491276e-06 1.898949e-05 5 5475973 5476079 107 + 1.826 2.042 0.725
ENSG00000164151 E027 0.5848434 0.0225648849 5.972514e-01 7.190419e-01 5 5476492 5476575 84 + 0.191 0.000 -10.516
ENSG00000164151 E028 84.0737445 0.0003697647 8.858215e-15 2.935903e-13 5 5486721 5486819 99 + 1.727 2.080 1.185
ENSG00000164151 E029 2.2069090 0.0066814937 6.946812e-02 1.424747e-01 5 5487915 5487958 44 + 0.350 0.685 1.631
ENSG00000164151 E030 354.5032797 0.0081694211 1.701637e-27 2.314214e-25 5 5489149 5490220 1072 + 2.305 2.775 1.564