ENSG00000164144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353617 ENSG00000164144 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFIP1 protein_coding protein_coding 9.315956 4.881483 14.71833 0.975941 0.4876003 1.59025 2.16038085 1.4302147 3.34904670 0.39149124 0.50990980 1.22176798 0.23391250 0.28643333 0.2270000 -0.05943333 0.56965238 0.01332736 FALSE TRUE
ENST00000356064 ENSG00000164144 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFIP1 protein_coding protein_coding 9.315956 4.881483 14.71833 0.975941 0.4876003 1.59025 3.15790955 0.2861519 5.32364555 0.28615193 0.35775758 4.17071254 0.30014583 0.09256667 0.3622333 0.26966667 0.11227676 0.01332736 FALSE TRUE
ENST00000405727 ENSG00000164144 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFIP1 protein_coding protein_coding 9.315956 4.881483 14.71833 0.975941 0.4876003 1.59025 2.19821476 0.4910967 3.88438377 0.24591500 0.30441866 2.95823411 0.17943750 0.08653333 0.2647333 0.17820000 0.22080251 0.01332736 FALSE TRUE
ENST00000451320 ENSG00000164144 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFIP1 protein_coding protein_coding 9.315956 4.881483 14.71833 0.975941 0.4876003 1.59025 0.45746677 0.1261445 0.56252645 0.12614446 0.28509341 2.07220407 0.07771250 0.04080000 0.0382000 -0.00260000 0.76409499 0.01332736 FALSE TRUE
ENST00000510497 ENSG00000164144 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFIP1 protein_coding processed_transcript 9.315956 4.881483 14.71833 0.975941 0.4876003 1.59025 0.78479591 1.6303472 0.78253231 0.67595095 0.43174448 -1.04945959 0.12055417 0.30023333 0.0517000 -0.24853333 0.01332736 0.01332736   FALSE
ENST00000510831 ENSG00000164144 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFIP1 protein_coding processed_transcript 9.315956 4.881483 14.71833 0.975941 0.4876003 1.59025 0.26625132 0.4564172 0.46889336 0.08278667 0.30881278 0.03808334 0.03560000 0.10973333 0.0314000 -0.07833333 0.36360274 0.01332736   FALSE
ENST00000514499 ENSG00000164144 HEK293_OSMI2_2hA HEK293_TMG_2hB ARFIP1 protein_coding processed_transcript 9.315956 4.881483 14.71833 0.975941 0.4876003 1.59025 0.08367991 0.2981765 0.03746603 0.29817650 0.03746603 -2.69878951 0.01757917 0.05843333 0.0024000 -0.05603333 0.82428821 0.01332736 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164144 E001 0.7019140 0.0177037688 1.727906e-01 2.918255e-01 4 152779937 152779938 2 + 0.115 0.381 2.220
ENSG00000164144 E002 0.7019140 0.0177037688 1.727906e-01 2.918255e-01 4 152779939 152779953 15 + 0.115 0.381 2.220
ENSG00000164144 E003 3.0855851 0.2343995915 8.287252e-01 8.923875e-01 4 152779954 152779970 17 + 0.535 0.579 0.203
ENSG00000164144 E004 11.1294395 0.0026662422 3.599685e-01 5.042830e-01 4 152779971 152779984 14 + 1.009 0.941 -0.253
ENSG00000164144 E005 16.2642925 0.0011477420 3.574297e-01 5.018434e-01 4 152779985 152779992 8 + 1.159 1.112 -0.170
ENSG00000164144 E006 46.6827504 0.0005577518 2.952769e-01 4.364123e-01 4 152779993 152780091 99 + 1.590 1.574 -0.053
ENSG00000164144 E007 20.8176616 0.0009215160 7.736538e-01 8.539603e-01 4 152780092 152780108 17 + 1.245 1.268 0.081
ENSG00000164144 E008 43.7703689 0.0005393399 5.087810e-02 1.107372e-01 4 152780109 152780226 118 + 1.574 1.494 -0.274
ENSG00000164144 E009 3.2250925 0.0921839055 2.048733e-01 3.322374e-01 4 152807204 152807248 45 + 0.492 0.768 1.208
ENSG00000164144 E010 4.5214374 0.0369796272 3.763306e-03 1.247763e-02 4 152809673 152809733 61 + 0.513 1.005 2.012
ENSG00000164144 E011 4.9567400 0.0198887563 7.861493e-04 3.209707e-03 4 152810080 152810388 309 + 0.533 1.061 2.123
ENSG00000164144 E012 60.0539658 0.0004551205 1.270843e-06 1.032186e-05 4 152829625 152829726 102 + 1.734 1.484 -0.853
ENSG00000164144 E013 0.0000000       4 152850643 152850647 5 +      
ENSG00000164144 E014 0.0000000       4 152850648 152850706 59 +      
ENSG00000164144 E015 0.0000000       4 152850707 152850727 21 +      
ENSG00000164144 E016 53.1099396 0.0004952644 4.105427e-06 2.977303e-05 4 152863606 152863714 109 + 1.685 1.431 -0.867
ENSG00000164144 E017 11.7148637 0.0074709723 1.353283e-01 2.415741e-01 4 152870753 152870848 96 + 1.051 0.904 -0.549
ENSG00000164144 E018 51.1718576 0.0013804040 4.048954e-07 3.647466e-06 4 152872452 152872564 113 + 1.678 1.370 -1.054
ENSG00000164144 E019 67.8649195 0.0031669281 1.288624e-04 6.538812e-04 4 152880963 152881184 222 + 1.782 1.597 -0.629
ENSG00000164144 E020 62.2198904 0.0003839031 3.741931e-06 2.742229e-05 4 152882723 152882880 158 + 1.749 1.522 -0.770
ENSG00000164144 E021 0.1515154 0.0436207850 1.000000e+00   4 152883245 152883316 72 + 0.061 0.001 -5.914
ENSG00000164144 E022 63.3277227 0.0004304666 6.112085e-05 3.370150e-04 4 152888133 152888307 175 + 1.749 1.566 -0.621
ENSG00000164144 E023 306.3872155 0.0005180494 3.556566e-10 5.719701e-09 4 152910064 152911569 1506 + 2.355 2.533 0.591
ENSG00000164144 E024 74.8758640 0.0408287810 6.955164e-06 4.794015e-05 4 152911570 152912002 433 + 1.624 2.142 1.743
ENSG00000164144 E025 1.1039203 0.4989075542 6.241060e-01 7.405501e-01 4 152912003 152912357 355 + 0.244 0.383 0.908
ENSG00000164144 E026 1.0425102 0.0118604150 7.320748e-01 8.236298e-01 4 152917008 152917084 77 + 0.280 0.231 -0.368
ENSG00000164144 E027 1.0445865 0.0703526925 7.421156e-01 8.311110e-01 4 152918403 152918463 61 + 0.280 0.230 -0.375