ENSG00000164142

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435205 ENSG00000164142 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP1A protein_coding protein_coding 1.141846 0.8251643 1.300229 0.04967599 0.06106894 0.6496867 1.02283546 0.8251643 0.97949475 0.04967599 0.04360159 0.244632 0.91113750 1 0.75883333 -0.24116667 0.0005370691 0.0005370691 FALSE TRUE
ENST00000503146 ENSG00000164142 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP1A protein_coding protein_coding 1.141846 0.8251643 1.300229 0.04967599 0.06106894 0.6496867 0.03592610 0.0000000 0.08087291 0.00000000 0.04326568 3.183850 0.02836250 0 0.06496667 0.06496667 0.3300661717 0.0005370691 FALSE FALSE
ENST00000512597 ENSG00000164142 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP1A protein_coding protein_coding 1.141846 0.8251643 1.300229 0.04967599 0.06106894 0.6496867 0.02590967 0.0000000 0.12598905 0.00000000 0.12598905 3.765419 0.01897917 0 0.09226667 0.09226667 0.8787208994 0.0005370691 FALSE TRUE
ENST00000513086 ENSG00000164142 HEK293_OSMI2_2hA HEK293_TMG_2hB FHIP1A protein_coding protein_coding 1.141846 0.8251643 1.300229 0.04967599 0.06106894 0.6496867 0.05717519 0.0000000 0.11387202 0.00000000 0.11387202 3.630778 0.04152083 0 0.08390000 0.08390000 0.8768863327 0.0005370691   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164142 E001 1.870569 0.0086762887 1.367780e-01 2.435997e-01 4 151409176 151409215 40 + 0.537 0.337 -1.059
ENSG00000164142 E002 2.311284 0.0123544817 1.317150e-01 2.365113e-01 4 151409216 151409245 30 + 0.600 0.408 -0.934
ENSG00000164142 E003 3.274285 0.0088701731 1.079255e-01 2.024554e-01 4 151409246 151409351 106 + 0.705 0.524 -0.796
ENSG00000164142 E004 3.546082 0.0046493092 4.036972e-03 1.324591e-02 4 151409352 151409465 114 + 0.789 0.409 -1.722
ENSG00000164142 E005 0.000000       4 151436435 151436517 83 +      
ENSG00000164142 E006 1.925084 0.0290244629 1.495572e-01 2.610629e-01 4 151454701 151454808 108 + 0.537 0.337 -1.056
ENSG00000164142 E007 1.494498 0.2225440865 9.888131e-01 9.970316e-01 4 151482524 151482608 85 + 0.371 0.414 0.237
ENSG00000164142 E008 1.535286 0.0562211224 1.132941e-01 2.103268e-01 4 151482609 151482648 40 + 0.501 0.251 -1.471
ENSG00000164142 E009 0.000000       4 151533012 151533048 37 +      
ENSG00000164142 E010 0.294498 0.3626578711 3.359423e-01   4 151534695 151534900 206 + 0.188 0.000 -9.271
ENSG00000164142 E011 7.800983 0.0220859218 3.007498e-02 7.210073e-02 4 151566138 151566364 227 + 1.021 0.812 -0.788
ENSG00000164142 E012 16.500511 0.0012031437 1.189340e-02 3.327726e-02 4 151577450 151578076 627 + 1.289 1.166 -0.432
ENSG00000164142 E013 7.145191 0.0024760014 4.131944e-02 9.346902e-02 4 151586641 151586799 159 + 0.974 0.811 -0.621
ENSG00000164142 E014 6.693869 0.0029920549 1.530946e-02 4.118853e-02 4 151588840 151588926 87 + 0.973 0.755 -0.844
ENSG00000164142 E015 9.728270 0.0018449431 1.747267e-02 4.598382e-02 4 151629702 151629869 168 + 1.093 0.925 -0.618
ENSG00000164142 E016 6.713941 0.0024421180 3.427847e-02 8.029319e-02 4 151638677 151638756 80 + 0.961 0.784 -0.681
ENSG00000164142 E017 10.078340 0.0017187848 7.163464e-02 1.460610e-01 4 151646558 151646748 191 + 1.084 0.982 -0.372
ENSG00000164142 E018 29.827893 0.0008632104 2.326911e-03 8.233742e-03 4 151649459 151650592 1134 + 1.533 1.434 -0.340
ENSG00000164142 E019 8.192453 0.0036327722 8.830068e-01 9.291278e-01 4 151656232 151656410 179 + 0.934 0.999 0.242
ENSG00000164142 E020 7.101080 0.0025464496 6.952714e-01 7.959072e-01 4 151656760 151656898 139 + 0.891 0.925 0.130
ENSG00000164142 E021 90.630051 0.0013508828 1.586101e-01 2.732748e-01 4 151662501 151667223 4723 + 1.937 1.979 0.142
ENSG00000164142 E022 10.022877 0.0024080851 4.250161e-01 5.679603e-01 4 151667224 151667315 92 + 1.032 1.032 0.001
ENSG00000164142 E023 120.289988 0.0302477726 5.020315e-05 2.828249e-04 4 151667316 151670290 2975 + 1.889 2.237 1.167
ENSG00000164142 E024 8.209380 0.0031967074 1.025849e-05 6.802145e-05 4 151670291 151670503 213 + 0.570 1.178 2.376