ENSG00000164134

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296543 ENSG00000164134 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA15 protein_coding protein_coding 33.53547 6.032276 62.62881 0.318118 2.110667 3.373893 22.405488 5.1170575 41.150053 0.3808399 1.4676230 3.005042 0.76016250 0.8465667 0.65696667 -0.18960000 1.499226e-06 2.271203e-42 FALSE TRUE
ENST00000398947 ENSG00000164134 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA15 protein_coding protein_coding 33.53547 6.032276 62.62881 0.318118 2.110667 3.373893 1.480056 0.7653886 1.822774 0.0418912 0.2905538 1.241037 0.07114583 0.1280333 0.02886667 -0.09916667 1.749052e-08 2.271203e-42 FALSE TRUE
ENST00000480277 ENSG00000164134 HEK293_OSMI2_2hA HEK293_TMG_2hB NAA15 protein_coding processed_transcript 33.53547 6.032276 62.62881 0.318118 2.110667 3.373893 9.296416 0.0000000 19.009278 0.0000000 0.2732135 10.893247 0.15169167 0.0000000 0.30393333 0.30393333 2.271203e-42 2.271203e-42 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164134 E001 134.0499454 0.0008248795 3.033090e-15 1.078269e-13 4 139301505 139301587 83 + 1.943 1.555 -1.314
ENSG00000164134 E002 249.4782922 0.0085590066 4.315304e-07 3.866446e-06 4 139301588 139301831 244 + 2.199 2.011 -0.627
ENSG00000164134 E003 0.0000000       4 139301984 139302181 198 +      
ENSG00000164134 E004 169.8611940 0.0049514539 1.346277e-04 6.795664e-04 4 139334174 139334258 85 + 2.026 1.924 -0.343
ENSG00000164134 E005 115.6856871 0.0051965655 2.293819e-04 1.089416e-03 4 139336848 139336872 25 + 1.864 1.732 -0.443
ENSG00000164134 E006 208.5606933 0.0022600686 6.464038e-10 9.934267e-09 4 139336873 139336952 80 + 2.121 1.928 -0.649
ENSG00000164134 E007 308.5292024 0.0004224382 2.265168e-14 7.069674e-13 4 139340912 139341069 158 + 2.288 2.124 -0.549
ENSG00000164134 E008 0.5933762 0.0209475549 1.000000e+00 1.000000e+00 4 139341070 139341073 4 + 0.147 0.000 -9.529
ENSG00000164134 E009 234.4875404 0.0001830999 2.164630e-10 3.602589e-09 4 139342826 139342960 135 + 2.169 2.028 -0.473
ENSG00000164134 E010 232.1977650 0.0012074199 1.233303e-07 1.230944e-06 4 139344186 139344339 154 + 2.161 2.050 -0.374
ENSG00000164134 E011 209.2439435 0.0002283943 2.967791e-06 2.222904e-05 4 139349462 139349581 120 + 2.113 2.036 -0.258
ENSG00000164134 E012 165.6305966 0.0005994598 2.027992e-03 7.313860e-03 4 139351191 139351286 96 + 2.008 1.983 -0.084
ENSG00000164134 E013 102.6440896 0.0002997766 6.414840e-05 3.517430e-04 4 139351505 139351534 30 + 1.812 1.686 -0.427
ENSG00000164134 E014 166.3334972 0.0002362982 3.289404e-06 2.441401e-05 4 139351535 139351611 77 + 2.018 1.915 -0.344
ENSG00000164134 E015 0.4417471 0.7247400488 1.000000e+00 1.000000e+00 4 139351612 139351613 2 + 0.114 0.000 -9.123
ENSG00000164134 E016 175.1865226 0.0002350057 3.271286e-07 3.003176e-06 4 139354026 139354098 73 + 2.042 1.921 -0.405
ENSG00000164134 E017 0.5922303 0.0180124517 4.102975e-01 5.538903e-01 4 139356489 139356583 95 + 0.114 0.313 1.809
ENSG00000164134 E018 263.6469233 0.0035369154 3.358184e-06 2.487383e-05 4 139357386 139357555 170 + 2.216 2.115 -0.339
ENSG00000164134 E019 266.1128463 0.0032018606 2.177357e-04 1.039813e-03 4 139359743 139359895 153 + 2.216 2.168 -0.160
ENSG00000164134 E020 271.4790674 0.0001842383 7.633970e-03 2.285811e-02 4 139360500 139360628 129 + 2.217 2.244 0.089
ENSG00000164134 E021 399.7541104 0.0011228971 1.332886e-05 8.602792e-05 4 139361724 139361937 214 + 2.389 2.365 -0.082
ENSG00000164134 E022 382.7970821 0.0067677541 6.576439e-02 1.363070e-01 4 139370211 139370404 194 + 2.365 2.394 0.098
ENSG00000164134 E023 141.9375500 0.0071200542 7.937181e-01 8.681376e-01 4 139376365 139376376 12 + 1.923 2.057 0.452
ENSG00000164134 E024 237.7969152 0.0058468750 7.593426e-01 8.437096e-01 4 139376377 139376473 97 + 2.150 2.253 0.346
ENSG00000164134 E025 234.2151447 0.0051672077 2.401805e-01 3.743419e-01 4 139378756 139378854 99 + 2.133 2.309 0.591
ENSG00000164134 E026 2.7303424 0.0085012507 1.831807e-01 3.051836e-01 4 139378855 139379335 481 + 0.381 0.718 1.587
ENSG00000164134 E027 95.2005699 0.0003325727 5.421479e-01 6.729542e-01 4 139384832 139384834 3 + 1.749 1.898 0.505
ENSG00000164134 E028 85.6517083 0.0008298265 4.074175e-02 9.239943e-02 4 139384835 139384835 1 + 1.692 1.921 0.776
ENSG00000164134 E029 287.3749397 0.0005969898 1.558348e-02 4.180872e-02 4 139384836 139384978 143 + 2.218 2.413 0.653
ENSG00000164134 E030 214.5607518 0.0001965528 1.891822e-01 3.127099e-01 4 139386133 139386167 35 + 2.097 2.262 0.551
ENSG00000164134 E031 254.3514860 0.0002844081 1.483413e-02 4.011535e-02 4 139386168 139386230 63 + 2.165 2.362 0.660
ENSG00000164134 E032 0.1451727 0.0426009342 6.962900e-01   4 139386231 139386547 317 + 0.042 0.000 -7.529
ENSG00000164134 E033 1552.9377280 0.0307995937 2.041805e-06 1.585302e-05 4 139387884 139391384 3501 + 2.906 3.335 1.427
ENSG00000164134 E034 1.5533704 0.1601928192 1.000000e+00 1.000000e+00 4 139393591 139393722 132 + 0.279 0.315 0.242
ENSG00000164134 E035 1.1405526 0.0111013400 3.374022e-02 7.923520e-02 4 139404398 139404490 93 + 0.147 0.620 2.981
ENSG00000164134 E036 0.9211837 0.0136968632 1.493320e-01 2.607542e-01 4 139417866 139420033 2168 + 0.147 0.493 2.395