ENSG00000164118

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296519 ENSG00000164118 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP44 protein_coding protein_coding 7.638168 1.191546 9.951635 0.1041623 0.243457 3.05149 0.5521435 0.73214247 0.5183197 0.03730503 0.5183197 -0.490285 0.19549167 0.62143333 0.05473333 -0.5667000 1.717212e-02 2.802412e-06 FALSE TRUE
ENST00000503780 ENSG00000164118 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP44 protein_coding protein_coding 7.638168 1.191546 9.951635 0.1041623 0.243457 3.05149 2.2585095 0.00000000 3.2219951 0.00000000 0.7017735 8.336281 0.27917083 0.00000000 0.32090000 0.3209000 2.802412e-06 2.802412e-06 FALSE TRUE
ENST00000505124 ENSG00000164118 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP44 protein_coding protein_coding 7.638168 1.191546 9.951635 0.1041623 0.243457 3.05149 1.7903294 0.10130489 2.2430453 0.10130489 0.1715575 4.339287 0.17279583 0.07303333 0.22526667 0.1522333 2.253201e-01 2.802412e-06 FALSE FALSE
ENST00000508483 ENSG00000164118 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP44 protein_coding retained_intron 7.638168 1.191546 9.951635 0.1041623 0.243457 3.05149 0.8178128 0.09362844 0.7991210 0.04813165 0.2317766 2.964935 0.10237083 0.08073333 0.08103333 0.0003000 9.982729e-01 2.802412e-06 FALSE TRUE
MSTRG.25742.10 ENSG00000164118 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP44 protein_coding   7.638168 1.191546 9.951635 0.1041623 0.243457 3.05149 0.3656203 0.00000000 0.5496079 0.00000000 0.1845069 5.806344 0.02723333 0.00000000 0.05490000 0.0549000 5.622907e-02 2.802412e-06 FALSE TRUE
MSTRG.25742.2 ENSG00000164118 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP44 protein_coding   7.638168 1.191546 9.951635 0.1041623 0.243457 3.05149 0.9461543 0.06745300 1.4288477 0.03494287 0.1094747 4.215449 0.09306667 0.06240000 0.14330000 0.0809000 1.072998e-01 2.802412e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164118 E001 11.5951046 0.0487516906 4.000489e-01 5.437732e-01 4 174283730 174283817 88 + 0.987 0.841 -0.551
ENSG00000164118 E002 14.9676496 0.0086618224 4.186010e-01 5.618488e-01 4 174283818 174283903 86 + 1.081 0.979 -0.371
ENSG00000164118 E003 9.0604697 0.0018436467 4.971866e-01 6.337291e-01 4 174283904 174283904 1 + 0.886 0.787 -0.386
ENSG00000164118 E004 9.2119851 0.0019230098 4.680883e-01 6.075123e-01 4 174283905 174283910 6 + 0.893 0.787 -0.412
ENSG00000164118 E005 9.3593479 0.0031376310 4.436319e-01 5.852208e-01 4 174283911 174283918 8 + 0.900 0.787 -0.438
ENSG00000164118 E006 9.4594561 0.0018662381 2.161086e-01 3.457194e-01 4 174283919 174283922 4 + 0.913 0.722 -0.752
ENSG00000164118 E007 10.4808618 0.0018050032 2.612535e-01 3.988982e-01 4 174283923 174283932 10 + 0.951 0.787 -0.631
ENSG00000164118 E008 9.8508401 0.0017462054 1.710872e-01 2.895993e-01 4 174283933 174283943 11 + 0.933 0.722 -0.825
ENSG00000164118 E009 3.5063414 0.0043965935 5.355774e-01 6.673784e-01 4 174283944 174283968 25 + 0.526 0.645 0.536
ENSG00000164118 E010 5.7446765 0.0028694066 6.642427e-01 7.720834e-01 4 174283969 174284017 49 + 0.717 0.645 -0.303
ENSG00000164118 E011 4.5665706 0.0035206635 9.334346e-01 9.620507e-01 4 174284018 174284020 3 + 0.626 0.645 0.084
ENSG00000164118 E012 4.4128651 0.0040478166 8.772433e-01 9.251603e-01 4 174284021 174284025 5 + 0.613 0.645 0.141
ENSG00000164118 E013 6.1832014 0.0082071989 9.060056e-01 9.442412e-01 4 174284026 174284061 36 + 0.737 0.722 -0.064
ENSG00000164118 E014 4.1403889 0.0081494957 4.134486e-01 5.569297e-01 4 174284062 174284140 79 + 0.571 0.722 0.646
ENSG00000164118 E015 0.1472490 0.0434089813 8.097863e-01   4 174285434 174285574 141 + 0.051 0.000 -7.310
ENSG00000164118 E016 17.8539110 0.0010280889 1.246014e-01 2.265607e-01 4 174297966 174298062 97 + 1.162 0.980 -0.662
ENSG00000164118 E017 0.1451727 0.0426487459 8.068947e-01   4 174299070 174299071 2 + 0.051 0.000 -7.314
ENSG00000164118 E018 31.6418955 0.0006238083 2.980843e-03 1.020717e-02 4 174299072 174299210 139 + 1.405 1.113 -1.031
ENSG00000164118 E019 25.7772888 0.0015870110 6.182275e-03 1.909473e-02 4 174302039 174302186 148 + 1.319 1.017 -1.078
ENSG00000164118 E020 26.8994352 0.0015687282 3.244242e-03 1.098482e-02 4 174303703 174303849 147 + 1.339 1.017 -1.149
ENSG00000164118 E021 29.3511366 0.0006928524 6.351657e-04 2.662939e-03 4 174304247 174304369 123 + 1.381 1.017 -1.296
ENSG00000164118 E022 28.0989206 0.0006760002 1.393733e-03 5.286373e-03 4 174308689 174308799 111 + 1.361 1.017 -1.224
ENSG00000164118 E023 23.9910714 0.0007734578 2.883725e-02 6.968012e-02 4 174308800 174308859 60 + 1.287 1.051 -0.841
ENSG00000164118 E024 39.8521412 0.0005569608 1.720402e-02 4.539410e-02 4 174309850 174310056 207 + 1.493 1.296 -0.681
ENSG00000164118 E025 24.7194560 0.0007993905 9.846842e-01 9.944954e-01 4 174310783 174310858 76 + 1.270 1.277 0.027
ENSG00000164118 E026 31.5657755 0.0038217972 3.737442e-01 5.181541e-01 4 174316166 174316290 125 + 1.358 1.439 0.279
ENSG00000164118 E027 3.9699601 0.0173203800 8.563873e-01 9.111945e-01 4 174316291 174316529 239 + 0.585 0.552 -0.151
ENSG00000164118 E028 14.8059112 0.0274203196 8.624116e-01 9.152808e-01 4 174316530 174316567 38 + 1.061 1.082 0.074
ENSG00000164118 E029 5.2790687 0.0030987149 8.532335e-01 9.091358e-01 4 174316568 174316686 119 + 0.674 0.645 -0.122
ENSG00000164118 E030 9.1894566 0.0463477368 8.808073e-01 9.275709e-01 4 174317335 174317379 45 + 0.885 0.844 -0.160
ENSG00000164118 E031 79.0296034 0.0004107115 4.144616e-01 5.578817e-01 4 174317380 174318539 1160 + 1.764 1.725 -0.131
ENSG00000164118 E032 3.9355378 0.0046820471 4.914958e-04 2.127943e-03 4 174318540 174318665 126 + 0.437 0.980 2.300
ENSG00000164118 E033 9.3156361 0.0137318153 4.421173e-01 5.837593e-01 4 174318666 174318834 169 + 0.864 0.980 0.435
ENSG00000164118 E034 31.8219306 0.0009143521 9.813224e-01 9.923540e-01 4 174318835 174319087 253 + 1.377 1.381 0.015
ENSG00000164118 E035 91.7480199 0.0003271346 5.199776e-24 5.160899e-22 4 174319088 174320331 1244 + 1.734 2.141 1.370
ENSG00000164118 E036 20.8438815 0.0167769918 1.596770e-03 5.950807e-03 4 174331482 174333380 1899 + 1.135 1.474 1.186