ENSG00000164082

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395052 ENSG00000164082 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM2 protein_coding protein_coding 0.4591143 0.8986127 0.2059634 0.07093306 0.02834156 -2.072879 0.1325857 0.2429551 0.09128682 0.07134633 0.02996501 -1.3204349 0.3027208 0.2657000 0.4312 0.1655000 0.5305769311 0.0001621861 FALSE TRUE
ENST00000464585 ENSG00000164082 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM2 protein_coding retained_intron 0.4591143 0.8986127 0.2059634 0.07093306 0.02834156 -2.072879 0.1578806 0.2218668 0.11467658 0.04174079 0.02493604 -0.8951057 0.4674708 0.2513333 0.5688 0.3174667 0.1929737734 0.0001621861 TRUE TRUE
ENST00000475478 ENSG00000164082 HEK293_OSMI2_2hA HEK293_TMG_2hB GRM2 protein_coding processed_transcript 0.4591143 0.8986127 0.2059634 0.07093306 0.02834156 -2.072879 0.1622508 0.4337908 0.00000000 0.03453935 0.00000000 -5.4718080 0.2210417 0.4829667 0.0000 -0.4829667 0.0001621861 0.0001621861 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164082 E001 0.2214452 0.042128727 1.00000000   3 51707068 51707087 20 + 0.001 0.070 7.054
ENSG00000164082 E002 0.2214452 0.042128727 1.00000000   3 51707088 51707089 2 + 0.000 0.070 9.088
ENSG00000164082 E003 1.0631447 0.012198908 0.17599950 0.29599695 3 51707090 51707167 78 + 0.000 0.310 11.233
ENSG00000164082 E004 0.7321030 0.019708639 0.90314175 0.94238477 3 51707305 51707410 106 + 0.207 0.183 -0.221
ENSG00000164082 E005 2.3509318 0.008342909 0.94145919 0.96719555 3 51707411 51707654 244 + 0.451 0.438 -0.069
ENSG00000164082 E006 9.1753905 0.002146932 0.08198321 0.16265593 3 51707655 51708844 1190 + 1.055 0.861 -0.725
ENSG00000164082 E007 0.9889485 0.016998810 0.75864219 0.84319190 3 51708845 51708847 3 + 0.207 0.271 0.511
ENSG00000164082 E008 2.5336803 0.006526102 0.45450343 0.59514036 3 51708848 51709193 346 + 0.346 0.490 0.778
ENSG00000164082 E009 2.6120332 0.006183240 0.05367233 0.11567786 3 51709194 51709433 240 + 0.721 0.409 -1.446
ENSG00000164082 E010 0.0000000       3 51711272 51711719 448 +      
ENSG00000164082 E011 2.0982549 0.007709396 0.01274164 0.03530339 3 51712473 51712581 109 + 0.721 0.310 -2.031
ENSG00000164082 E012 10.2415935 0.001962817 0.80688505 0.87732980 3 51712582 51713310 729 + 0.979 0.954 -0.093
ENSG00000164082 E013 2.1714069 0.008077031 0.01287938 0.03563442 3 51713311 51713963 653 + 0.721 0.311 -2.030
ENSG00000164082 E014 0.6966155 0.017408133 0.89377618 0.93606144 3 51713964 51714068 105 + 0.207 0.182 -0.223
ENSG00000164082 E015 0.8449086 0.015167680 0.96458668 0.98167957 3 51714069 51714121 53 + 0.207 0.229 0.191
ENSG00000164082 E016 5.5897487 0.043001238 0.69633878 0.79672007 3 51714122 51715061 940 + 0.768 0.716 -0.213
ENSG00000164082 E017 6.0879109 0.010751072 0.70660160 0.80472962 3 51715062 51715183 122 + 0.721 0.780 0.238
ENSG00000164082 E018 16.2367041 0.001937448 0.23285447 0.36582028 3 51715184 51716017 834 + 1.031 1.153 0.441
ENSG00000164082 E019 7.9543345 0.002410563 0.45880576 0.59908494 3 51716018 51716137 120 + 0.769 0.871 0.402
ENSG00000164082 E020 7.5060438 0.002457868 0.06811589 0.14024334 3 51717637 51717817 181 + 0.607 0.881 1.117
ENSG00000164082 E021 3.8922800 0.004988255 0.26382894 0.40174524 3 51718039 51718112 74 + 0.451 0.651 0.927
ENSG00000164082 E022 6.0647297 0.003038662 0.75383484 0.83963026 3 51718113 51718252 140 + 0.721 0.769 0.192
ENSG00000164082 E023 6.3194989 0.003038917 0.62818185 0.74377155 3 51718253 51718613 361 + 0.721 0.793 0.290