ENSG00000164074

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398965 ENSG00000164074 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD18 protein_coding protein_coding 3.711801 1.243545 5.581648 0.2632323 0.2601667 2.157259 0.68815156 0.20718879 0.7639133 0.10448983 0.44135315 1.833222 0.17248750 0.16166667 0.13936667 -0.02230000 9.408260e-01 3.272898e-06 FALSE TRUE
ENST00000444616 ENSG00000164074 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD18 protein_coding protein_coding 3.711801 1.243545 5.581648 0.2632323 0.2601667 2.157259 0.19447998 0.08215543 0.3522541 0.08215543 0.35225407 1.974861 0.07832083 0.08293333 0.06480000 -0.01813333 8.689572e-01 3.272898e-06 FALSE TRUE
ENST00000473040 ENSG00000164074 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD18 protein_coding nonsense_mediated_decay 3.711801 1.243545 5.581648 0.2632323 0.2601667 2.157259 0.56091818 0.16819920 1.1263387 0.05290657 0.10839443 2.672830 0.13865417 0.13030000 0.20310000 0.07280000 4.614817e-01 3.272898e-06 FALSE TRUE
ENST00000513371 ENSG00000164074 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD18 protein_coding protein_coding 3.711801 1.243545 5.581648 0.2632323 0.2601667 2.157259 0.28277476 0.31510603 0.4356201 0.09172988 0.13901811 0.454904 0.10254167 0.24600000 0.07650000 -0.16950000 4.679246e-02 3.272898e-06 FALSE FALSE
ENST00000611882 ENSG00000164074 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD18 protein_coding protein_coding 3.711801 1.243545 5.581648 0.2632323 0.2601667 2.157259 0.70496670 0.00000000 1.1482018 0.00000000 0.21495832 6.855743 0.14906250 0.00000000 0.20313333 0.20313333 3.272898e-06 3.272898e-06 FALSE TRUE
ENST00000645843 ENSG00000164074 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD18 protein_coding protein_coding 3.711801 1.243545 5.581648 0.2632323 0.2601667 2.157259 0.93186976 0.47089588 1.1736255 0.09903763 0.20570997 1.299416 0.22760000 0.37916667 0.20816667 -0.17100000 5.928638e-02 3.272898e-06 FALSE TRUE
MSTRG.25451.3 ENSG00000164074 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD18 protein_coding   3.711801 1.243545 5.581648 0.2632323 0.2601667 2.157259 0.09976931 0.00000000 0.0000000 0.00000000 0.00000000 0.000000 0.06429583 0.00000000 0.00000000 0.00000000   3.272898e-06 FALSE TRUE
MSTRG.25451.8 ENSG00000164074 HEK293_OSMI2_2hA HEK293_TMG_2hB ABHD18 protein_coding   3.711801 1.243545 5.581648 0.2632323 0.2601667 2.157259 0.14795987 0.00000000 0.3947466 0.00000000 0.01263867 5.338947 0.02916667 0.00000000 0.07083333 0.07083333 3.477222e-03 3.272898e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164074 E001 1.7400561 0.0100410418 0.064191100 0.133680829 4 127965306 127965314 9 + 0.296 0.628 1.728
ENSG00000164074 E002 2.7751794 0.0143260831 0.458940372 0.599178971 4 127965315 127965356 42 + 0.494 0.628 0.612
ENSG00000164074 E003 3.2461850 0.0062970732 0.688182322 0.790361470 4 127965357 127965376 20 + 0.558 0.628 0.314
ENSG00000164074 E004 4.1672670 0.0230191514 0.137168937 0.244143527 4 127965377 127965405 29 + 0.595 0.834 0.987
ENSG00000164074 E005 3.2503496 0.0053524697 0.166061836 0.283080935 4 127965406 127965410 5 + 0.516 0.744 0.992
ENSG00000164074 E006 8.8103620 0.0384356684 0.495228788 0.632071307 4 127965411 127965473 63 + 0.904 1.002 0.365
ENSG00000164074 E007 16.4118614 0.0181774481 0.128819780 0.232510369 4 127965474 127965505 32 + 1.132 1.307 0.617
ENSG00000164074 E008 27.1982596 0.0121386181 0.015131936 0.040783552 4 127965506 127965606 101 + 1.327 1.537 0.726
ENSG00000164074 E009 2.3270870 0.0072438620 0.002773510 0.009593973 4 127965954 127966056 103 + 0.296 0.792 2.408
ENSG00000164074 E010 30.0677372 0.0011918311 0.066879634 0.138186107 4 127982939 127983047 109 + 1.392 1.524 0.455
ENSG00000164074 E011 27.0534521 0.0008314709 0.571775933 0.698009068 4 127984339 127984423 85 + 1.392 1.351 -0.143
ENSG00000164074 E012 20.3936434 0.0009834252 0.983292099 0.993629788 4 127989721 127989821 101 + 1.266 1.268 0.006
ENSG00000164074 E013 2.8173283 0.0066361074 0.007136361 0.021577681 4 128001716 128001760 45 + 0.613 0.000 -12.677
ENSG00000164074 E014 25.6462284 0.0007514676 0.040437064 0.091823854 4 128008920 128008998 79 + 1.392 1.220 -0.603
ENSG00000164074 E015 25.6789982 0.0012976769 0.156406304 0.270333934 4 128009107 128009191 85 + 1.383 1.268 -0.403
ENSG00000164074 E016 0.8868276 0.1046619783 0.317320992 0.460182724 4 128009192 128009193 2 + 0.173 0.365 1.428
ENSG00000164074 E017 0.1515154 0.0470032444 1.000000000   4 128009194 128009201 8 + 0.066 0.000 -8.777
ENSG00000164074 E018 7.8543838 0.0022288713 0.620974973 0.738024514 4 128009560 128009635 76 + 0.876 0.944 0.255
ENSG00000164074 E019 10.8703553 0.0016166554 0.637730307 0.751563539 4 128011673 128011674 2 + 1.026 0.975 -0.190
ENSG00000164074 E020 17.2007144 0.0010300663 0.973751425 0.987634306 4 128011675 128011700 26 + 1.195 1.202 0.024
ENSG00000164074 E021 1.3381542 0.0099225919 0.094680114 0.182405236 4 128014309 128014325 17 + 0.392 0.000 -11.835
ENSG00000164074 E022 1.1760296 0.0117048676 0.126456096 0.229213698 4 128017358 128017362 5 + 0.363 0.000 -11.688
ENSG00000164074 E023 27.0151471 0.0007724890 0.248906523 0.384646585 4 128017363 128017501 139 + 1.400 1.311 -0.310
ENSG00000164074 E024 22.8342993 0.0008233458 0.120976864 0.221331968 4 128020080 128020169 90 + 1.337 1.202 -0.473
ENSG00000164074 E025 22.7983338 0.0008812297 0.070292861 0.143845357 4 128021137 128021238 102 + 1.343 1.184 -0.559
ENSG00000164074 E026 57.9251118 0.0006306503 0.065847594 0.136455541 4 128028475 128028853 379 + 1.722 1.622 -0.339
ENSG00000164074 E027 40.3057589 0.0032333821 0.050830643 0.110657100 4 128030510 128030672 163 + 1.578 1.440 -0.473
ENSG00000164074 E028 5.3886786 0.0552131835 0.855255971 0.910512380 4 128030673 128031313 641 + 0.758 0.739 -0.076
ENSG00000164074 E029 148.4478242 0.0017120792 0.092986765 0.179790609 4 128035762 128039953 4192 + 2.094 2.153 0.198