ENSG00000164056

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394339 ENSG00000164056 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRY1 protein_coding protein_coding 6.041667 4.078979 6.485052 0.117317 0.2518563 0.6676004 0.29119766 0.02486145 0.4105693 0.02486145 0.1651473 3.5926393 0.046845833 0.006333333 0.06406667 0.05773333 0.163393443 0.001505764 FALSE TRUE
ENST00000505319 ENSG00000164056 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRY1 protein_coding protein_coding 6.041667 4.078979 6.485052 0.117317 0.2518563 0.6676004 0.61585519 0.20799449 1.1558299 0.20799449 0.2512347 2.4189938 0.112579167 0.053033333 0.17930000 0.12626667 0.202885066 0.001505764 FALSE TRUE
ENST00000507703 ENSG00000164056 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRY1 protein_coding protein_coding 6.041667 4.078979 6.485052 0.117317 0.2518563 0.6676004 0.05877043 0.00000000 0.4701634 0.00000000 0.4701634 5.5854537 0.008579167 0.000000000 0.06863333 0.06863333 0.899560227 0.001505764 FALSE TRUE
ENST00000515726 ENSG00000164056 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRY1 protein_coding processed_transcript 6.041667 4.078979 6.485052 0.117317 0.2518563 0.6676004 1.20843478 0.30400214 1.6012085 0.30400214 0.2875630 2.3592969 0.160620833 0.070566667 0.24453333 0.17396667 0.161241821 0.001505764   FALSE
ENST00000622283 ENSG00000164056 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRY1 protein_coding protein_coding 6.041667 4.078979 6.485052 0.117317 0.2518563 0.6676004 3.02055712 3.05682155 2.1948641 0.20568754 0.4558317 -0.4760545 0.500520833 0.748866667 0.34120000 -0.40766667 0.001505764 0.001505764 FALSE TRUE
MSTRG.25423.4 ENSG00000164056 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRY1 protein_coding   6.041667 4.078979 6.485052 0.117317 0.2518563 0.6676004 0.49703477 0.33375253 0.2876829 0.18374119 0.2228310 -0.2075940 0.119141667 0.083966667 0.04723333 -0.03673333 0.820686235 0.001505764 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164056 E001 0.4502799 0.029860011 1.396200e-01 2.475094e-01 4 123396795 123396800 6 + 0.263 0.000 -9.528
ENSG00000164056 E002 2.3574835 0.016677818 1.281215e-03 4.914204e-03 4 123396801 123396810 10 + 0.712 0.140 -3.446
ENSG00000164056 E003 3.8459054 0.004250915 2.747350e-03 9.514255e-03 4 123396811 123396838 28 + 0.851 0.402 -1.999
ENSG00000164056 E004 7.8157863 0.002241841 2.269372e-02 5.711704e-02 4 123396839 123396932 94 + 1.052 0.802 -0.941
ENSG00000164056 E005 16.9793775 0.001091711 6.826432e-05 3.717830e-04 4 123397611 123397856 246 + 1.375 1.054 -1.141
ENSG00000164056 E006 15.0521240 0.001305830 2.290051e-02 5.753356e-02 4 123397857 123398184 328 + 1.279 1.096 -0.653
ENSG00000164056 E007 8.0551890 0.005685367 1.226484e-02 3.416715e-02 4 123398185 123398385 201 + 1.062 0.776 -1.084
ENSG00000164056 E008 8.1573986 0.002837663 1.802408e-02 4.718394e-02 4 123398386 123398513 128 + 1.062 0.803 -0.979
ENSG00000164056 E009 2.2571478 0.027025795 1.832572e-02 4.784412e-02 4 123399510 123399794 285 + 0.663 0.246 -2.241
ENSG00000164056 E010 3.3130194 0.004832276 3.756837e-01 5.200932e-01 4 123399968 123400380 413 + 0.689 0.565 -0.538
ENSG00000164056 E011 252.5309444 0.001311186 1.515034e-15 5.595997e-14 4 123401537 123403760 2224 + 2.353 2.454 0.337