ENSG00000164050

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296440 ENSG00000164050 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB1 protein_coding protein_coding 3.87166 3.617657 3.10916 0.3938551 0.292607 -0.2178805 0.74495384 1.04430319 0.6271626 0.13082060 0.10042370 -0.7265563 0.19777083 0.287766667 0.20880000 -0.07896667 4.837992e-01 1.144795e-11 FALSE TRUE
ENST00000358536 ENSG00000164050 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB1 protein_coding protein_coding 3.87166 3.617657 3.10916 0.3938551 0.292607 -0.2178805 0.30947551 0.00000000 0.5118559 0.00000000 0.04846187 5.7055797 0.08971667 0.000000000 0.16486667 0.16486667 1.144795e-11 1.144795e-11 FALSE TRUE
ENST00000462738 ENSG00000164050 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB1 protein_coding retained_intron 3.87166 3.617657 3.10916 0.3938551 0.292607 -0.2178805 0.22588561 0.02032685 0.2467205 0.02032685 0.07712010 3.0815309 0.05910833 0.006833333 0.07596667 0.06913333 1.427061e-02 1.144795e-11 FALSE FALSE
ENST00000464294 ENSG00000164050 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB1 protein_coding retained_intron 3.87166 3.617657 3.10916 0.3938551 0.292607 -0.2178805 0.19151257 0.00000000 0.2132585 0.00000000 0.10791227 4.4806430 0.04705417 0.000000000 0.07580000 0.07580000 1.847737e-01 1.144795e-11   FALSE
ENST00000478171 ENSG00000164050 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB1 protein_coding retained_intron 3.87166 3.617657 3.10916 0.3938551 0.292607 -0.2178805 0.06018617 0.00000000 0.1694898 0.00000000 0.04036634 4.1658301 0.01860833 0.000000000 0.05806667 0.05806667 1.570729e-03 1.144795e-11 FALSE TRUE
ENST00000485535 ENSG00000164050 HEK293_OSMI2_2hA HEK293_TMG_2hB PLXNB1 protein_coding retained_intron 3.87166 3.617657 3.10916 0.3938551 0.292607 -0.2178805 0.91863361 1.43334485 0.3869712 0.10508416 0.04914693 -1.8623096 0.22772083 0.403400000 0.12676667 -0.27663333 1.060632e-04 1.144795e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164050 E001 0.4428904 0.2831110529 4.591183e-01 0.5993438724 3 48403854 48403855 2 - 0.000 0.182 12.210
ENSG00000164050 E002 38.3522627 0.0050390191 1.159533e-04 0.0005953441 3 48403856 48404185 330 - 1.369 1.641 0.933
ENSG00000164050 E003 23.3618639 0.0008965655 7.782262e-04 0.0031808549 3 48404186 48404230 45 - 1.162 1.428 0.931
ENSG00000164050 E004 23.7364309 0.0008286720 1.106104e-05 0.0000727572 3 48404231 48404305 75 - 1.094 1.452 1.258
ENSG00000164050 E005 33.9892241 0.0007196152 2.698513e-05 0.0001623040 3 48404306 48404485 180 - 1.302 1.584 0.973
ENSG00000164050 E006 16.6671006 0.0022018537 1.201740e-02 0.0335725175 3 48404486 48404508 23 - 1.047 1.280 0.830
ENSG00000164050 E007 15.9986839 0.0049636303 2.947241e-03 0.0101091038 3 48404509 48404547 39 - 0.976 1.275 1.076
ENSG00000164050 E008 22.0592649 0.0011616295 6.114350e-03 0.0189083638 3 48404548 48404590 43 - 1.175 1.394 0.770
ENSG00000164050 E009 25.3653135 0.0008033420 4.059928e-01 0.5496533269 3 48405724 48405798 75 - 1.345 1.403 0.202
ENSG00000164050 E010 0.8094091 0.0155854381 3.113986e-01 0.4538513407 3 48405799 48406065 267 - 0.356 0.176 -1.340
ENSG00000164050 E011 0.3697384 0.0274424043 3.811303e-01 0.5254295106 3 48406723 48406822 100 - 0.000 0.176 12.177
ENSG00000164050 E012 24.7300172 0.0008335865 4.670752e-02 0.1033111489 3 48406823 48406898 76 - 1.273 1.420 0.511
ENSG00000164050 E013 0.0000000       3 48407022 48407026 5 -      
ENSG00000164050 E014 19.4944649 0.0009689033 7.148656e-02 0.1458108772 3 48407027 48407091 65 - 1.175 1.323 0.523
ENSG00000164050 E015 18.7348125 0.0010597156 3.740264e-02 0.0862283818 3 48409329 48409398 70 - 1.136 1.313 0.624
ENSG00000164050 E016 18.3660547 0.0010909783 2.664543e-03 0.0092661069 3 48409399 48409476 78 - 1.063 1.328 0.941
ENSG00000164050 E017 0.4439371 0.0216139675 2.993131e-02 0.0718257363 3 48409477 48409570 94 - 0.356 0.000 -14.548
ENSG00000164050 E018 28.5436744 0.0007376411 8.583160e-02 0.1687180480 3 48409571 48409731 161 - 1.353 1.471 0.406
ENSG00000164050 E019 20.0690270 0.0009823112 2.258713e-01 0.3574317495 3 48409905 48410014 110 - 1.221 1.318 0.340
ENSG00000164050 E020 17.8319290 0.0011111097 6.073599e-02 0.1278713905 3 48410015 48410077 63 - 1.123 1.286 0.578
ENSG00000164050 E021 21.3242697 0.0008663537 3.916564e-02 0.0894848165 3 48410296 48410380 85 - 1.199 1.363 0.575
ENSG00000164050 E022 0.6611159 0.0185670856 1.307411e-01 0.2351850438 3 48410381 48410383 3 - 0.356 0.097 -2.338
ENSG00000164050 E023 21.2970148 0.0009011111 7.143753e-02 0.1457249899 3 48410455 48410558 104 - 1.221 1.363 0.495
ENSG00000164050 E024 1.2114274 0.0483965339 4.907463e-01 0.6280893286 3 48410559 48410867 309 - 0.430 0.300 -0.765
ENSG00000164050 E025 18.1649373 0.0010226310 2.634280e-01 0.4013287812 3 48410868 48410946 79 - 1.187 1.280 0.328
ENSG00000164050 E026 14.9237548 0.0077559188 2.123756e-01 0.3413299390 3 48410947 48411005 59 - 1.094 1.217 0.441
ENSG00000164050 E027 11.0459846 0.0223619004 9.066988e-01 0.9447434675 3 48411006 48411036 31 - 1.047 1.061 0.052
ENSG00000164050 E028 24.7101559 0.0053926305 7.412900e-01 0.8305153475 3 48411863 48412009 147 - 1.369 1.394 0.085
ENSG00000164050 E029 2.3927780 0.0064280386 4.659495e-01 0.6055367868 3 48412010 48412237 228 - 0.598 0.477 -0.564
ENSG00000164050 E030 18.4904439 0.0098568077 6.042313e-01 0.7248272972 3 48412238 48412304 67 - 1.232 1.279 0.166
ENSG00000164050 E031 28.3836182 0.0007090488 5.253897e-01 0.6587696523 3 48412442 48412620 179 - 1.407 1.448 0.142
ENSG00000164050 E032 28.2184518 0.0007421775 7.094494e-01 0.8068248165 3 48412742 48412959 218 - 1.421 1.444 0.079
ENSG00000164050 E033 18.7237809 0.0020534183 2.086204e-02 0.0532964337 3 48413069 48413169 101 - 1.385 1.198 -0.654
ENSG00000164050 E034 1.4706519 0.0120172633 7.977014e-02 0.1591982562 3 48413170 48413219 50 - 0.549 0.244 -1.754
ENSG00000164050 E035 3.4613892 0.0045964534 2.411152e-05 0.0001468197 3 48413220 48413669 450 - 0.935 0.302 -2.924
ENSG00000164050 E036 15.5769627 0.0012234693 5.192091e-02 0.1125842381 3 48413670 48413758 89 - 1.292 1.123 -0.599
ENSG00000164050 E037 13.3505414 0.0013148089 4.391194e-04 0.0019250835 3 48413759 48413818 60 - 1.311 0.990 -1.149
ENSG00000164050 E038 1.3545237 0.2622522923 4.483529e-01 0.5896461409 3 48413819 48413894 76 - 0.492 0.295 -1.117
ENSG00000164050 E039 8.6952309 0.0020195527 3.459483e-02 0.0808882181 3 48413895 48413907 13 - 1.094 0.861 -0.865
ENSG00000164050 E040 15.3899426 0.0011948744 4.648675e-01 0.6045495768 3 48413908 48413986 79 - 1.221 1.155 -0.236
ENSG00000164050 E041 13.8138095 0.0614165330 7.232992e-01 0.8171585059 3 48413987 48414071 85 - 1.109 1.155 0.164
ENSG00000164050 E042 19.4706354 0.0013273697 6.237513e-01 0.7402450805 3 48414799 48414990 192 - 1.253 1.291 0.133
ENSG00000164050 E043 10.9513363 0.0024292439 8.999135e-01 0.9401450966 3 48414991 48415041 51 - 1.030 1.043 0.045
ENSG00000164050 E044 9.6131873 0.0019003428 7.632354e-01 0.8466167924 3 48415176 48415211 36 - 1.013 0.979 -0.126
ENSG00000164050 E045 15.4296729 0.0011752083 1.351214e-01 0.2412571005 3 48415212 48415347 136 - 1.263 1.131 -0.468
ENSG00000164050 E046 0.7320925 0.0282120203 3.827431e-03 0.0126579045 3 48415348 48415535 188 - 0.493 0.000 -15.284
ENSG00000164050 E047 18.5274720 0.0073434239 1.500149e-01 0.2616931706 3 48415583 48415759 177 - 1.337 1.207 -0.454
ENSG00000164050 E048 15.5510321 0.0325425471 9.590616e-01 0.9783480794 3 48416031 48416167 137 - 1.175 1.187 0.040
ENSG00000164050 E049 12.2167164 0.0017389612 1.757806e-01 0.2956996305 3 48416346 48416451 106 - 1.175 1.042 -0.477
ENSG00000164050 E050 3.3141507 0.0071423872 1.434064e-02 0.0390035312 3 48416452 48416833 382 - 0.813 0.440 -1.646
ENSG00000164050 E051 13.7146614 0.0013896443 1.528633e-01 0.2655420627 3 48417911 48418062 152 - 1.221 1.089 -0.472
ENSG00000164050 E052 0.1472490 0.0420321756 2.966981e-01   3 48418189 48418190 2 - 0.153 0.000 -12.963
ENSG00000164050 E053 10.7080231 0.0020108049 2.540174e-01 0.3906549560 3 48418191 48418286 96 - 1.109 0.990 -0.432
ENSG00000164050 E054 10.0793748 0.0019290897 2.935413e-01 0.4346167610 3 48418287 48418363 77 - 1.079 0.967 -0.410
ENSG00000164050 E055 9.4669730 0.0018399354 1.690572e-01 0.2869631166 3 48418449 48418542 94 - 1.079 0.930 -0.548
ENSG00000164050 E056 11.8409343 0.0111110551 4.720603e-01 0.6111263935 3 48418917 48419039 123 - 1.122 1.045 -0.280
ENSG00000164050 E057 10.2465104 0.0092286122 6.872503e-03 0.0208934454 3 48419244 48419366 123 - 1.187 0.892 -1.079
ENSG00000164050 E058 2.2163602 0.0193904032 1.348900e-02 0.0370543186 3 48419367 48419576 210 - 0.718 0.302 -2.077
ENSG00000164050 E059 9.7732511 0.0019802415 1.561426e-01 0.2700009915 3 48419577 48419674 98 - 1.094 0.943 -0.555
ENSG00000164050 E060 14.4232867 0.0029549056 5.761005e-02 0.1225237935 3 48419675 48420078 404 - 1.263 1.089 -0.619
ENSG00000164050 E061 5.4481942 0.0889748904 7.112007e-01 0.8081940024 3 48420079 48420223 145 - 0.841 0.758 -0.329
ENSG00000164050 E062 3.6234345 0.0066721472 2.350241e-01 0.3683768434 3 48420224 48420257 34 - 0.752 0.575 -0.755
ENSG00000164050 E063 7.5773932 0.0022154007 8.412709e-02 0.1660134725 3 48420665 48420773 109 - 1.030 0.830 -0.755
ENSG00000164050 E064 7.6254790 0.0022743487 1.094482e-01 0.2047520475 3 48420848 48420956 109 - 1.030 0.846 -0.694
ENSG00000164050 E065 0.2924217 0.0290785164 9.442856e-02   3 48421224 48421227 4 - 0.266 0.000 -13.962
ENSG00000164050 E066 10.5793283 0.0016050350 7.498227e-03 0.0225067990 3 48421228 48421384 157 - 1.199 0.930 -0.978
ENSG00000164050 E067 11.3597311 0.0025599577 1.424694e-02 0.0387873559 3 48421674 48421806 133 - 1.210 0.967 -0.880
ENSG00000164050 E068 9.9978804 0.0019550835 3.690354e-02 0.0852749202 3 48422105 48422205 101 - 1.136 0.918 -0.803
ENSG00000164050 E069 9.7668833 0.0018310888 5.217833e-02 0.1130376306 3 48422331 48422412 82 - 1.123 0.918 -0.754
ENSG00000164050 E070 5.7624744 0.0030211090 1.797538e-01 0.3008506471 3 48422413 48422443 31 - 0.913 0.741 -0.673
ENSG00000164050 E071 4.4016080 0.0040884604 3.627826e-01 0.5072032447 3 48422444 48422459 16 - 0.784 0.654 -0.532
ENSG00000164050 E072 12.2014811 0.0014036278 3.847803e-03 0.0127148427 3 48422765 48422947 183 - 1.253 0.979 -0.989
ENSG00000164050 E073 33.0375706 0.0007947801 3.006242e-05 0.0001788536 3 48423505 48424617 1113 - 1.649 1.395 -0.871
ENSG00000164050 E074 4.6220236 0.0041241470 8.518903e-02 0.1677177367 3 48425281 48425333 53 - 0.866 0.629 -0.961
ENSG00000164050 E075 2.8273392 0.0122937371 2.723571e-02 0.0664672934 3 48429253 48429481 229 - 0.752 0.399 -1.625
ENSG00000164050 E076 1.2555363 0.0106458751 3.213877e-02 0.0761261855 3 48430008 48430086 79 - 0.549 0.176 -2.340