ENSG00000164045

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302506 ENSG00000164045 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC25A protein_coding protein_coding 77.73199 89.45536 73.205 10.20822 1.95172 -0.28919 10.256081 7.897708 14.402114 1.615554 0.7450170 0.8659505 0.1337750 0.0903 0.1975333 0.1072333 0.018156782 0.001063878 FALSE TRUE
ENST00000351231 ENSG00000164045 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC25A protein_coding protein_coding 77.73199 89.45536 73.205 10.20822 1.95172 -0.28919 9.553135 13.977532 6.570849 2.623867 0.5383759 -1.0877958 0.1204167 0.1533 0.0895000 -0.0638000 0.002565382 0.001063878 FALSE TRUE
MSTRG.22890.4 ENSG00000164045 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC25A protein_coding   77.73199 89.45536 73.205 10.20822 1.95172 -0.28919 45.115490 58.316440 34.977331 7.536466 2.5766903 -0.7373174 0.5790000 0.6514 0.4766333 -0.1747667 0.002293072 0.001063878 FALSE TRUE
MSTRG.22890.5 ENSG00000164045 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC25A protein_coding   77.73199 89.45536 73.205 10.20822 1.95172 -0.28919 10.905885 8.149629 14.235947 1.256930 1.1393137 0.8039761 0.1426000 0.0912 0.1955667 0.1043667 0.001063878 0.001063878 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164045 E001 88.0898095 0.0066508310 5.097829e-11 9.459971e-10 3 48157146 48157214 69 - 1.635 2.101 1.571
ENSG00000164045 E002 105.5047909 0.0132682512 9.941870e-08 1.009734e-06 3 48157215 48157227 13 - 1.721 2.172 1.517
ENSG00000164045 E003 394.4884293 0.0110052204 1.185662e-07 1.188341e-06 3 48157228 48157325 98 - 2.348 2.721 1.244
ENSG00000164045 E004 543.4114954 0.0067419048 2.891159e-08 3.264327e-07 3 48157326 48157367 42 - 2.526 2.847 1.065
ENSG00000164045 E005 4804.9744024 0.0021099841 8.433282e-22 6.561232e-20 3 48157368 48159085 1718 - 3.539 3.762 0.743
ENSG00000164045 E006 626.8400004 0.0001974728 7.485950e-01 8.357870e-01 3 48159344 48159455 112 - 2.751 2.834 0.275
ENSG00000164045 E007 509.3140293 0.0009918926 8.234910e-01 8.887921e-01 3 48164307 48164401 95 - 2.667 2.737 0.232
ENSG00000164045 E008 345.8626493 0.0001580387 8.271996e-01 8.913678e-01 3 48164402 48164437 36 - 2.499 2.573 0.248
ENSG00000164045 E009 563.6689728 0.0002260567 1.305026e-04 6.610163e-04 3 48165636 48165734 99 - 2.744 2.760 0.052
ENSG00000164045 E010 509.1622148 0.0001966118 2.373732e-05 1.447319e-04 3 48165831 48165893 63 - 2.706 2.713 0.026
ENSG00000164045 E011 629.3238724 0.0001590726 2.485941e-16 1.019823e-14 3 48167846 48167944 99 - 2.826 2.782 -0.145
ENSG00000164045 E012 793.0895890 0.0001095771 1.208524e-23 1.151087e-21 3 48174284 48174457 174 - 2.930 2.879 -0.173
ENSG00000164045 E013 0.8952612 0.0153163249 4.818337e-02 1.059595e-01 3 48174458 48174753 296 - 0.429 0.119 -2.425
ENSG00000164045 E014 1.2887440 0.0104252795 2.807898e-01 4.206618e-01 3 48177366 48177370 5 - 0.224 0.460 1.481
ENSG00000164045 E015 484.9687814 0.0003630307 4.428072e-12 9.755611e-11 3 48177371 48177442 72 - 2.714 2.665 -0.164
ENSG00000164045 E016 640.7429329 0.0001462599 1.290580e-29 2.093292e-27 3 48177854 48177988 135 - 2.856 2.768 -0.291
ENSG00000164045 E017 549.9562365 0.0014052201 5.168690e-12 1.128102e-10 3 48180721 48180840 120 - 2.788 2.700 -0.290
ENSG00000164045 E018 516.4724639 0.0023474061 3.506632e-09 4.698832e-08 3 48182929 48183027 99 - 2.763 2.669 -0.310
ENSG00000164045 E019 180.7395453 0.0023848748 6.638859e-09 8.460325e-08 3 48183028 48183030 3 - 2.328 2.199 -0.429
ENSG00000164045 E020 338.8822786 0.0015901416 2.713718e-10 4.445359e-09 3 48183800 48183836 37 - 2.583 2.485 -0.325
ENSG00000164045 E021 339.1886960 0.0011211117 9.312940e-10 1.388782e-08 3 48184653 48184695 43 - 2.573 2.495 -0.262
ENSG00000164045 E022 355.3898357 0.0022899098 4.570285e-07 4.073329e-06 3 48186703 48186779 77 - 2.593 2.514 -0.264
ENSG00000164045 E023 280.5073243 0.0051437492 1.808501e-09 2.553780e-08 3 48187778 48187894 117 - 2.538 2.362 -0.587
ENSG00000164045 E024 251.0656136 0.0152195520 1.438384e-06 1.154797e-05 3 48187895 48188215 321 - 2.518 2.276 -0.809
ENSG00000164045 E025 107.5617293 0.0182033721 1.584530e-02 4.239056e-02 3 48188216 48188369 154 - 2.091 1.980 -0.374
ENSG00000164045 E026 52.9620541 0.0162030240 2.179657e-08 2.523556e-07 3 48188370 48188466 97 - 1.900 1.527 -1.265