ENSG00000164024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296411 ENSG00000164024 HEK293_OSMI2_2hA HEK293_TMG_2hB METAP1 protein_coding protein_coding 36.43808 23.93876 49.75391 2.909728 0.9698195 1.055149 29.110544 17.813248 40.14583 1.997023 0.6798369 1.171849 0.7941042 0.7463667 0.8071333 0.06076667 2.666631e-01 1.518802e-21 FALSE TRUE
ENST00000514051 ENSG00000164024 HEK293_OSMI2_2hA HEK293_TMG_2hB METAP1 protein_coding protein_coding 36.43808 23.93876 49.75391 2.909728 0.9698195 1.055149 1.145969 4.243422 0.00000 1.154970 0.0000000 -8.732480 0.0509500 0.1728333 0.0000000 -0.17283333 1.518802e-21 1.518802e-21 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164024 E001 0.4355181 0.6013617387 5.459607e-01 6.762160e-01 4 98995631 98995632 2 + 0.215 0.000 -10.418
ENSG00000164024 E002 1.6242451 0.0238732948 2.846678e-01 4.249252e-01 4 98995633 98995658 26 + 0.467 0.298 -0.973
ENSG00000164024 E003 14.0686829 0.0489942025 6.153092e-01 7.336057e-01 4 98995659 98995720 62 + 1.127 1.212 0.302
ENSG00000164024 E004 37.5229497 0.0013544289 4.332874e-01 5.756917e-01 4 98995721 98995739 19 + 1.566 1.568 0.006
ENSG00000164024 E005 52.6264479 0.0004806683 8.552575e-02 1.682548e-01 4 98995740 98995753 14 + 1.722 1.684 -0.128
ENSG00000164024 E006 63.3766081 0.0004168609 1.148337e-02 3.231471e-02 4 98995754 98995765 12 + 1.811 1.742 -0.233
ENSG00000164024 E007 114.9925061 0.0006906446 2.846771e-03 9.814243e-03 4 98995766 98995829 64 + 2.064 2.005 -0.199
ENSG00000164024 E008 121.2816270 0.0002919605 1.604971e-03 5.977305e-03 4 98995830 98995867 38 + 2.087 2.030 -0.191
ENSG00000164024 E009 8.2571852 0.0021746102 7.791373e-03 2.325334e-02 4 99005769 99005866 98 + 1.028 0.736 -1.122
ENSG00000164024 E010 0.0000000       4 99005867 99005870 4 +      
ENSG00000164024 E011 0.0000000       4 99022295 99022424 130 +      
ENSG00000164024 E012 0.0000000       4 99022772 99023259 488 +      
ENSG00000164024 E013 149.5226857 0.0002232890 4.693429e-07 4.174637e-06 4 99028867 99028918 52 + 2.192 2.086 -0.355
ENSG00000164024 E014 1.6158141 0.0111242820 6.476296e-03 1.986199e-02 4 99031508 99031662 155 + 0.526 0.000 -12.253
ENSG00000164024 E015 95.2858355 0.0003580382 3.516009e-08 3.904211e-07 4 99034230 99034232 3 + 2.015 1.845 -0.572
ENSG00000164024 E016 220.3706233 0.0012205089 4.339795e-07 3.885817e-06 4 99034233 99034342 110 + 2.359 2.255 -0.344
ENSG00000164024 E017 155.5283794 0.0052180740 4.606965e-03 1.483937e-02 4 99035400 99035460 61 + 2.203 2.114 -0.295
ENSG00000164024 E018 6.2826573 0.0378194079 6.056126e-04 2.553845e-03 4 99035954 99036011 58 + 0.972 0.394 -2.502
ENSG00000164024 E019 15.8698476 0.0156279655 2.730329e-02 6.660992e-02 4 99036043 99036089 47 + 1.270 1.072 -0.704
ENSG00000164024 E020 8.2895167 0.0022659671 8.370108e-07 7.069828e-06 4 99037767 99037934 168 + 1.085 0.395 -2.915
ENSG00000164024 E021 3.2493967 0.0084305783 1.229583e-03 4.741122e-03 4 99037935 99037941 7 + 0.741 0.174 -3.192
ENSG00000164024 E022 9.8770517 0.0016805180 1.134400e-03 4.418989e-03 4 99039203 99039373 171 + 1.115 0.773 -1.286
ENSG00000164024 E023 100.3762949 0.0060993343 3.306100e-01 4.742092e-01 4 99039374 99039393 20 + 1.989 1.980 -0.032
ENSG00000164024 E024 156.7852921 0.0008662816 2.820231e-01 4.219856e-01 4 99039394 99039465 72 + 2.175 2.192 0.055
ENSG00000164024 E025 192.9909427 0.0002456614 2.890918e-01 4.297688e-01 4 99041043 99041126 84 + 2.263 2.286 0.079
ENSG00000164024 E026 278.8134408 0.0002086449 7.707526e-02 1.548050e-01 4 99043249 99043387 139 + 2.425 2.438 0.043
ENSG00000164024 E027 157.4326575 0.0011297430 5.177938e-04 2.226485e-03 4 99045179 99045189 11 + 2.203 2.139 -0.215
ENSG00000164024 E028 300.1777303 0.0001920037 3.950598e-02 9.011787e-02 4 99045190 99045310 121 + 2.459 2.468 0.028
ENSG00000164024 E029 308.5316994 0.0001493144 5.252473e-02 1.136555e-01 4 99048733 99048876 144 + 2.469 2.481 0.039
ENSG00000164024 E030 211.8589212 0.0001955955 1.376512e-01 2.448073e-01 4 99057753 99057818 66 + 2.304 2.318 0.047
ENSG00000164024 E031 340.9322777 0.0001827270 2.241927e-01 3.554345e-01 4 99061154 99061429 276 + 2.488 2.564 0.253
ENSG00000164024 E032 1146.1151802 0.0036231856 7.618753e-15 2.553246e-13 4 99061430 99062809 1380 + 2.945 3.176 0.769