ENSG00000164023

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359079 ENSG00000164023 HEK293_OSMI2_2hA HEK293_TMG_2hB SGMS2 protein_coding protein_coding 2.518125 0.5841166 4.18153 0.04044804 0.1470458 2.818659 0.04329173 0.23453077 0.0000000 0.12046893 0.0000000 -4.611944 0.05463750 0.4072000 0.00000000 -0.40720000 0.02670649 0.02670649 FALSE TRUE
ENST00000394684 ENSG00000164023 HEK293_OSMI2_2hA HEK293_TMG_2hB SGMS2 protein_coding protein_coding 2.518125 0.5841166 4.18153 0.04044804 0.1470458 2.818659 1.05547384 0.06754064 1.9032407 0.06754064 0.2812518 4.624922 0.38485833 0.1333000 0.45903333 0.32573333 0.17526655 0.02670649 FALSE TRUE
ENST00000503862 ENSG00000164023 HEK293_OSMI2_2hA HEK293_TMG_2hB SGMS2 protein_coding protein_coding 2.518125 0.5841166 4.18153 0.04044804 0.1470458 2.818659 0.26510754 0.00000000 0.5126591 0.00000000 0.3386390 5.707798 0.07624583 0.0000000 0.11730000 0.11730000 0.57774769 0.02670649 FALSE FALSE
ENST00000506462 ENSG00000164023 HEK293_OSMI2_2hA HEK293_TMG_2hB SGMS2 protein_coding processed_transcript 2.518125 0.5841166 4.18153 0.04044804 0.1470458 2.818659 0.22774109 0.00000000 0.5723873 0.00000000 0.3793574 5.863907 0.05679167 0.0000000 0.14040000 0.14040000 0.58304216 0.02670649 FALSE FALSE
ENST00000690982 ENSG00000164023 HEK293_OSMI2_2hA HEK293_TMG_2hB SGMS2 protein_coding protein_coding 2.518125 0.5841166 4.18153 0.04044804 0.1470458 2.818659 0.60818135 0.07765005 0.6598290 0.05035875 0.3452833 2.933966 0.30392917 0.1267333 0.15550000 0.02876667 1.00000000 0.02670649 FALSE TRUE
MSTRG.25281.3 ENSG00000164023 HEK293_OSMI2_2hA HEK293_TMG_2hB SGMS2 protein_coding   2.518125 0.5841166 4.18153 0.04044804 0.1470458 2.818659 0.04023526 0.20439516 0.0000000 0.12482998 0.0000000 -4.422200 0.06019167 0.3327667 0.00000000 -0.33276667 0.03033510 0.02670649 FALSE TRUE
MSTRG.25281.4 ENSG00000164023 HEK293_OSMI2_2hA HEK293_TMG_2hB SGMS2 protein_coding   2.518125 0.5841166 4.18153 0.04044804 0.1470458 2.818659 0.19395902 0.00000000 0.3574913 0.00000000 0.2328557 5.199638 0.04481667 0.0000000 0.08506667 0.08506667 0.62617597 0.02670649 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164023 E001 1.0319011 0.0121591782 7.889379e-01 8.648916e-01 4 107824563 107824592 30 + 0.286 0.226 -0.448
ENSG00000164023 E002 3.1031918 0.0052989331 2.595919e-01 3.970107e-01 4 107824593 107824716 124 + 0.596 0.374 -1.111
ENSG00000164023 E003 4.8245370 0.0035176148 1.574420e-01 2.717045e-01 4 107824717 107824793 77 + 0.740 0.484 -1.135
ENSG00000164023 E004 0.1472490 0.0438364826 1.000000e+00   4 107824882 107824931 50 + 0.063 0.000 -7.095
ENSG00000164023 E005 2.5174180 0.0059694326 1.344050e-01 2.402792e-01 4 107824932 107825207 276 + 0.542 0.226 -1.863
ENSG00000164023 E006 1.8091717 0.0090199643 8.809557e-01 9.276860e-01 4 107825208 107825253 46 + 0.407 0.374 -0.185
ENSG00000164023 E007 9.1691107 0.0018949773 2.408705e-02 5.999129e-02 4 107858472 107858553 82 + 0.986 0.645 -1.348
ENSG00000164023 E008 1.5050967 0.0100713851 4.724644e-01 6.115117e-01 4 107858554 107858584 31 + 0.379 0.226 -1.032
ENSG00000164023 E009 0.0000000       4 107893238 107893255 18 +      
ENSG00000164023 E010 0.0000000       4 107893256 107893273 18 +      
ENSG00000164023 E011 0.0000000       4 107893274 107893382 109 +      
ENSG00000164023 E012 0.0000000       4 107893383 107893477 95 +      
ENSG00000164023 E013 0.0000000       4 107893478 107893658 181 +      
ENSG00000164023 E014 0.0000000       4 107894248 107894450 203 +      
ENSG00000164023 E015 12.5749666 0.0052150476 5.877817e-02 1.245383e-01 4 107895310 107895447 138 + 1.101 0.854 -0.922
ENSG00000164023 E016 12.7182483 0.0721671467 4.514342e-01 5.923728e-01 4 107895448 107895542 95 + 1.084 0.935 -0.552
ENSG00000164023 E017 35.1959467 0.0007454457 3.691592e-02 8.529936e-02 4 107895543 107896008 466 + 1.506 1.346 -0.552
ENSG00000164023 E018 15.7588432 0.0133249671 7.045617e-01 8.030874e-01 4 107899575 107899692 118 + 1.152 1.102 -0.181
ENSG00000164023 E019 18.3966583 0.0280925564 1.132932e-01 2.103268e-01 4 107903233 107903386 154 + 1.242 1.027 -0.773
ENSG00000164023 E020 0.1451727 0.0431197273 1.000000e+00   4 107907200 107907374 175 + 0.063 0.000 -7.099
ENSG00000164023 E021 0.0000000       4 107907944 107908227 284 +      
ENSG00000164023 E022 18.1729452 0.0035868072 4.961362e-01 6.328670e-01 4 107908565 107908731 167 + 1.218 1.145 -0.259
ENSG00000164023 E023 181.0668665 0.0003072030 1.870881e-08 2.193408e-07 4 107910350 107915047 4698 + 2.153 2.260 0.355