ENSG00000164011

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372503 ENSG00000164011 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF691 protein_coding protein_coding 15.04143 21.63081 10.20975 1.0071 0.0706637 -1.082394 1.063396 1.0071816 0.8273765 0.7838495 0.6914128 -0.2806289 0.07233750 0.04693333 0.08013333 0.03320000 0.97251865 0.01631618 FALSE TRUE
ENST00000372506 ENSG00000164011 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF691 protein_coding protein_coding 15.04143 21.63081 10.20975 1.0071 0.0706637 -1.082394 2.145353 4.3949156 1.3586595 0.4147577 1.3586595 -1.6863507 0.13828750 0.20470000 0.13433333 -0.07036667 0.21926264 0.01631618 FALSE TRUE
ENST00000372507 ENSG00000164011 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF691 protein_coding protein_coding 15.04143 21.63081 10.20975 1.0071 0.0706637 -1.082394 2.977098 4.0042380 2.3422609 0.7067573 0.3671998 -0.7710780 0.20273750 0.18566667 0.22990000 0.04423333 0.74703232 0.01631618 FALSE TRUE
ENST00000372508 ENSG00000164011 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF691 protein_coding protein_coding 15.04143 21.63081 10.20975 1.0071 0.0706637 -1.082394 4.762630 9.0057814 2.5966589 0.5538636 0.3843003 -1.7902507 0.29869167 0.41580000 0.25396667 -0.16183333 0.01631618 0.01631618 FALSE TRUE
ENST00000397034 ENSG00000164011 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF691 protein_coding protein_coding 15.04143 21.63081 10.20975 1.0071 0.0706637 -1.082394 1.248111 0.8926266 0.9837639 0.3504813 0.1112776 0.1387737 0.08998333 0.04160000 0.09623333 0.05463333 0.27803901 0.01631618 FALSE TRUE
ENST00000651192 ENSG00000164011 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF691 protein_coding protein_coding 15.04143 21.63081 10.20975 1.0071 0.0706637 -1.082394 2.427105 1.7593996 1.8881134 1.0477608 1.0309659 0.1013063 0.17064583 0.07716667 0.18450000 0.10733333 0.87902325 0.01631618 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000164011 E001 0.554665 0.0214933905 0.9392488830 0.965835920 1 42846573 42846608 36 + 0.160 0.169 0.097
ENSG00000164011 E002 0.554665 0.0214933905 0.9392488830 0.965835920 1 42846609 42846612 4 + 0.160 0.169 0.097
ENSG00000164011 E003 1.147939 0.0117301486 0.5158983886 0.650511182 1 42846613 42846621 9 + 0.369 0.290 -0.491
ENSG00000164011 E004 3.248281 0.0050130054 0.9621102013 0.980098356 1 42846622 42846625 4 + 0.565 0.612 0.210
ENSG00000164011 E005 3.393454 0.0047000501 0.7100187268 0.807252789 1 42846626 42846627 2 + 0.615 0.612 -0.012
ENSG00000164011 E006 22.587513 0.0107266967 0.3044682756 0.446471929 1 42846628 42846636 9 + 1.350 1.324 -0.089
ENSG00000164011 E007 36.480543 0.0008622143 0.1994429517 0.325543397 1 42846637 42846657 21 + 1.542 1.535 -0.024
ENSG00000164011 E008 50.228494 0.0052485401 0.0511498227 0.111211372 1 42849291 42849413 123 + 1.707 1.658 -0.166
ENSG00000164011 E009 7.485692 0.0069574962 0.0078827113 0.023484221 1 42849555 42849564 10 + 1.051 0.795 -0.967
ENSG00000164011 E010 36.220341 0.0006343785 0.0919070424 0.178079177 1 42849565 42849615 51 + 1.559 1.529 -0.101
ENSG00000164011 E011 62.012525 0.0025171943 0.0403633171 0.091684964 1 42849616 42849742 127 + 1.789 1.758 -0.107
ENSG00000164011 E012 12.795043 0.0035784597 0.0069189217 0.021014429 1 42850659 42850686 28 + 1.231 1.041 -0.684
ENSG00000164011 E013 13.348565 0.0016124511 0.0009434289 0.003766001 1 42850687 42850743 57 + 1.275 1.041 -0.836
ENSG00000164011 E014 7.299720 0.0024326718 0.0227935545 0.057314254 1 42850923 42850949 27 + 1.015 0.811 -0.774
ENSG00000164011 E015 674.007516 0.0069489546 0.0001680176 0.000826700 1 42850950 42852477 1528 + 2.703 2.830 0.421