ENSG00000163956

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296325 ENSG00000163956 HEK293_OSMI2_2hA HEK293_TMG_2hB LRPAP1 protein_coding processed_transcript 295.2968 424.747 201.2322 13.40891 6.884398 -1.077705 132.2454 190.91161 88.43893 6.228243 3.501839 -1.1100639 0.4474833 0.4495333 0.4395667 -0.009966667 0.8437429935 0.0005710388    
ENST00000650633 ENSG00000163956 HEK293_OSMI2_2hA HEK293_TMG_2hB LRPAP1 protein_coding processed_transcript 295.2968 424.747 201.2322 13.40891 6.884398 -1.077705 63.1793 81.10899 52.34832 5.806683 3.984544 -0.6316209 0.2217167 0.1906000 0.2598333 0.069233333 0.0294186312 0.0005710388 FALSE  
MSTRG.24486.6 ENSG00000163956 HEK293_OSMI2_2hA HEK293_TMG_2hB LRPAP1 protein_coding   295.2968 424.747 201.2322 13.40891 6.884398 -1.077705 90.4663 141.85910 52.60731 3.938320 1.751908 -1.4309511 0.2978083 0.3341333 0.2618000 -0.072333333 0.0005710388 0.0005710388 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163956 E001 0.000000       4 3500359 3500416 58 -      
ENSG00000163956 E002 39.960360 3.861042e-02 1.904713e-02 4.943856e-02 4 3503612 3505402 1791 - 1.300 1.593 1.008
ENSG00000163956 E003 9.430006 1.835989e-03 7.646503e-02 1.538436e-01 4 3505403 3505691 289 - 0.769 0.999 0.880
ENSG00000163956 E004 4.628738 3.626717e-03 6.095969e-01 7.290742e-01 4 3505692 3505763 72 - 0.629 0.708 0.334
ENSG00000163956 E005 17.200818 6.318647e-02 9.588806e-01 9.782338e-01 4 3505764 3506699 936 - 1.209 1.188 -0.072
ENSG00000163956 E006 5.177905 9.090584e-02 9.254014e-01 9.570395e-01 4 3506700 3506760 61 - 0.727 0.736 0.036
ENSG00000163956 E007 42.115335 2.129138e-03 1.613983e-01 2.769127e-01 4 3506761 3509184 2424 - 1.625 1.535 -0.309
ENSG00000163956 E008 117.224759 3.409631e-03 3.090616e-02 7.373320e-02 4 3509185 3511933 2749 - 2.070 1.969 -0.339
ENSG00000163956 E009 2466.992962 1.881188e-04 1.944815e-13 5.308925e-12 4 3511934 3512932 999 - 3.260 3.334 0.247
ENSG00000163956 E010 2031.501192 7.785267e-05 1.117710e-20 7.761977e-19 4 3512933 3513036 104 - 3.161 3.252 0.304
ENSG00000163956 E011 2032.954240 8.434917e-05 3.386695e-08 3.777001e-07 4 3514752 3514846 95 - 3.192 3.245 0.177
ENSG00000163956 E012 2113.613526 8.012704e-05 1.040270e-04 5.406156e-04 4 3514847 3514925 79 - 3.222 3.258 0.120
ENSG00000163956 E013 1192.472227 1.124168e-04 7.446271e-01 8.328848e-01 4 3514926 3514928 3 - 2.999 3.002 0.010
ENSG00000163956 E014 21.072835 3.008850e-03 1.509722e-04 7.513787e-04 4 3515882 3516115 234 - 1.481 1.173 -1.075
ENSG00000163956 E015 2110.898547 6.977020e-05 4.769418e-01 6.155483e-01 4 3516116 3516196 81 - 3.246 3.252 0.019
ENSG00000163956 E016 1142.088176 8.175980e-04 4.162523e-01 5.596201e-01 4 3516197 3516198 2 - 2.996 2.981 -0.051
ENSG00000163956 E017 9.319238 1.912429e-03 8.903895e-02 1.736605e-01 4 3516387 3516574 188 - 0.769 0.991 0.849
ENSG00000163956 E018 11.162924 4.387036e-03 7.816502e-01 8.597139e-01 4 3516575 3516718 144 - 0.986 1.017 0.114
ENSG00000163956 E019 16.561533 3.260627e-03 7.047463e-01 8.032358e-01 4 3517661 3518033 373 - 1.194 1.156 -0.137
ENSG00000163956 E020 3111.272851 8.729954e-05 1.885555e-03 6.869609e-03 4 3518034 3518192 159 - 3.438 3.412 -0.086
ENSG00000163956 E021 2763.496251 6.569613e-05 3.845255e-11 7.273084e-10 4 3518871 3518991 121 - 3.408 3.354 -0.180
ENSG00000163956 E022 2573.836306 6.560967e-05 5.392068e-06 3.809776e-05 4 3520072 3520193 122 - 3.366 3.327 -0.129
ENSG00000163956 E023 9.858112 1.749045e-03 9.096621e-01 9.465920e-01 4 3520194 3520229 36 - 0.961 0.973 0.046
ENSG00000163956 E024 4.494439 7.332889e-02 4.083157e-01 5.519109e-01 4 3523393 3523501 109 - 0.769 0.625 -0.601
ENSG00000163956 E025 2630.184377 8.909903e-05 7.266847e-06 4.983646e-05 4 3524907 3525051 145 - 3.376 3.336 -0.131
ENSG00000163956 E026 16.688462 1.337785e-03 2.985538e-01 4.400127e-01 4 3525052 3525146 95 - 1.251 1.155 -0.340
ENSG00000163956 E027 10.885162 5.090033e-03 4.048387e-04 1.793333e-03 4 3531983 3532208 226 - 1.264 0.894 -1.345
ENSG00000163956 E028 2023.701045 6.095980e-04 2.120608e-03 7.597831e-03 4 3532209 3532467 259 - 3.266 3.220 -0.151