ENSG00000163946

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000459993 ENSG00000163946 HEK293_OSMI2_2hA HEK293_TMG_2hB TASOR protein_coding retained_intron 19.30027 4.585033 33.19012 0.686704 1.21532 2.853041 2.685774 1.0738370 4.380456 0.2102449 0.5257870 2.018223 0.19097500 0.2315000 0.1318000 -0.09970000 3.257996e-02 2.752326e-26 FALSE TRUE
ENST00000478052 ENSG00000163946 HEK293_OSMI2_2hA HEK293_TMG_2hB TASOR protein_coding processed_transcript 19.30027 4.585033 33.19012 0.686704 1.21532 2.853041 1.101557 0.0000000 2.100893 0.0000000 0.5361879 7.721710 0.03102083 0.0000000 0.0638000 0.06380000 6.831238e-05 2.752326e-26 FALSE FALSE
ENST00000485156 ENSG00000163946 HEK293_OSMI2_2hA HEK293_TMG_2hB TASOR protein_coding processed_transcript 19.30027 4.585033 33.19012 0.686704 1.21532 2.853041 4.657595 1.9209226 7.240720 0.3607003 1.1586046 1.908834 0.27185000 0.4143333 0.2167667 -0.19756667 5.394674e-03 2.752326e-26 FALSE FALSE
ENST00000493960 ENSG00000163946 HEK293_OSMI2_2hA HEK293_TMG_2hB TASOR protein_coding protein_coding 19.30027 4.585033 33.19012 0.686704 1.21532 2.853041 4.011379 0.0000000 7.138150 0.0000000 0.3274433 9.481426 0.15765833 0.0000000 0.2149333 0.21493333 2.752326e-26 2.752326e-26 FALSE TRUE
ENST00000683822 ENSG00000163946 HEK293_OSMI2_2hA HEK293_TMG_2hB TASOR protein_coding protein_coding 19.30027 4.585033 33.19012 0.686704 1.21532 2.853041 2.505381 0.8508211 5.094175 0.0421625 0.1635437 2.567893 0.13004167 0.1959667 0.1539333 -0.04203333 6.029671e-01 2.752326e-26 FALSE TRUE
MSTRG.23131.5 ENSG00000163946 HEK293_OSMI2_2hA HEK293_TMG_2hB TASOR protein_coding   19.30027 4.585033 33.19012 0.686704 1.21532 2.853041 1.838033 0.6526868 3.757320 0.2014431 0.5460195 2.507140 0.09108750 0.1409667 0.1138000 -0.02716667 8.448152e-01 2.752326e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163946 E001 1.2584533 0.3706475772 1.946739e-03 7.061555e-03 3 56620132 56620132 1 - 0.046 0.864 5.830
ENSG00000163946 E002 100.4663858 0.0310376275 1.086186e-05 7.157381e-05 3 56620133 56620544 412 - 1.734 2.205 1.582
ENSG00000163946 E003 349.3632684 0.0014409560 1.323998e-12 3.183089e-11 3 56620545 56622737 2193 - 2.322 2.572 0.833
ENSG00000163946 E004 25.0569538 0.0007867816 3.057871e-01 4.479343e-01 3 56622738 56622858 121 - 1.222 1.360 0.486
ENSG00000163946 E005 4.0461283 0.0204945053 2.237730e-03 7.959655e-03 3 56622859 56622861 3 - 0.443 0.982 2.276
ENSG00000163946 E006 17.1143684 0.0035892532 6.055827e-05 3.342145e-04 3 56622862 56623003 142 - 1.000 1.443 1.570
ENSG00000163946 E007 58.4677049 0.0229067362 1.068344e-05 7.053551e-05 3 56623004 56623116 113 - 1.508 1.959 1.528
ENSG00000163946 E008 232.5995779 0.0195528549 1.469924e-03 5.539413e-03 3 56623117 56623566 450 - 2.140 2.425 0.950
ENSG00000163946 E009 156.5632686 0.0002228190 1.126075e-01 2.093590e-01 3 56623567 56623843 277 - 2.000 2.107 0.358
ENSG00000163946 E010 150.4058241 0.0003375165 2.338815e-02 5.855310e-02 3 56624479 56624643 165 - 1.978 2.113 0.455
ENSG00000163946 E011 56.3102499 0.0004319367 1.906911e-01 3.146180e-01 3 56624828 56624834 7 - 1.559 1.687 0.437
ENSG00000163946 E012 120.0883689 0.0002987575 8.002018e-01 8.726280e-01 3 56624835 56625006 172 - 1.894 1.948 0.182
ENSG00000163946 E013 91.0558217 0.0002833493 2.674964e-01 4.058234e-01 3 56627037 56627145 109 - 1.786 1.765 -0.071
ENSG00000163946 E014 73.3922581 0.0008978373 2.490114e-02 6.166839e-02 3 56627582 56627648 67 - 1.703 1.593 -0.374
ENSG00000163946 E015 71.1869019 0.0003433283 2.752610e-02 6.706280e-02 3 56627649 56627741 93 - 1.689 1.582 -0.364
ENSG00000163946 E016 83.3293540 0.0003533664 7.935506e-02 1.584968e-01 3 56628492 56628614 123 - 1.752 1.687 -0.220
ENSG00000163946 E017 0.7469680 0.0168436499 7.127370e-01 8.093768e-01 3 56628615 56628640 26 - 0.192 0.000 -10.193
ENSG00000163946 E018 3.4879075 0.0044145795 6.737942e-01 7.793864e-01 3 56628744 56629103 360 - 0.523 0.463 -0.291
ENSG00000163946 E019 295.6961222 0.0006337696 1.593356e-01 2.742280e-01 3 56633044 56633843 800 - 2.290 2.287 -0.009
ENSG00000163946 E020 59.3328499 0.0036663360 4.657509e-02 1.030736e-01 3 56633844 56633898 55 - 1.615 1.499 -0.397
ENSG00000163946 E021 63.4645703 0.0064331550 4.963909e-02 1.085245e-01 3 56633899 56633966 68 - 1.644 1.524 -0.408
ENSG00000163946 E022 1.3297351 0.0099515121 3.043813e-01 4.463858e-01 3 56633967 56633972 6 - 0.301 0.000 -10.987
ENSG00000163946 E023 74.7178791 0.0047290506 4.609486e-02 1.022090e-01 3 56638706 56638765 60 - 1.710 1.605 -0.358
ENSG00000163946 E024 105.9574613 0.0019589534 3.441528e-04 1.556687e-03 3 56639986 56640130 145 - 1.867 1.688 -0.605
ENSG00000163946 E025 173.7224585 0.0002474345 4.505998e-08 4.904049e-07 3 56641349 56641752 404 - 2.082 1.872 -0.707
ENSG00000163946 E026 236.0331679 0.0170341563 1.047899e-04 5.441475e-04 3 56646522 56647223 702 - 2.217 1.973 -0.818
ENSG00000163946 E027 75.0621947 0.0079459930 3.980671e-03 1.308815e-02 3 56648822 56648893 72 - 1.723 1.524 -0.675
ENSG00000163946 E028 67.9944113 0.0150049613 3.139112e-02 7.466451e-02 3 56648985 56649057 73 - 1.678 1.512 -0.568
ENSG00000163946 E029 97.7825702 0.0003425513 3.428082e-05 2.009468e-04 3 56660731 56660834 104 - 1.837 1.623 -0.723
ENSG00000163946 E030 79.2512902 0.0003788678 4.141328e-03 1.353891e-02 3 56660914 56660968 55 - 1.739 1.593 -0.498
ENSG00000163946 E031 64.5878154 0.0003936581 6.378197e-02 1.329955e-01 3 56660969 56661017 49 - 1.648 1.560 -0.300
ENSG00000163946 E032 69.7117231 0.0008106838 5.857158e-02 1.241784e-01 3 56662385 56662490 106 - 1.680 1.593 -0.298
ENSG00000163946 E033 49.2908632 0.0004388522 1.006544e-03 3.981063e-03 3 56663541 56663572 32 - 1.548 1.302 -0.848
ENSG00000163946 E034 3.1461654 0.0047736461 2.707662e-01 4.094136e-01 3 56663573 56664331 759 - 0.444 0.683 1.102
ENSG00000163946 E035 68.8444607 0.0005453759 2.863081e-03 9.861856e-03 3 56666260 56666384 125 - 1.683 1.511 -0.585
ENSG00000163946 E036 73.4590365 0.0003233508 6.728635e-05 3.670371e-04 3 56668397 56668558 162 - 1.717 1.471 -0.837
ENSG00000163946 E037 69.3885303 0.0007474856 4.754544e-05 2.693341e-04 3 56669700 56669791 92 - 1.694 1.427 -0.912
ENSG00000163946 E038 63.5693283 0.0010463149 5.783591e-05 3.208069e-04 3 56670073 56670145 73 - 1.659 1.378 -0.962
ENSG00000163946 E039 0.2924217 0.0273318897 1.000000e+00   3 56671352 56671599 248 - 0.087 0.000 -8.924
ENSG00000163946 E040 73.5017512 0.0004927188 7.242842e-05 3.918987e-04 3 56671600 56671692 93 - 1.717 1.471 -0.837
ENSG00000163946 E041 80.5211732 0.0003760087 2.636589e-07 2.468099e-06 3 56673580 56673725 146 - 1.761 1.427 -1.138
ENSG00000163946 E042 140.6783449 0.0058732297 2.669382e-13 7.145775e-12 3 56682676 56683789 1114 - 1.889 2.303 1.387