ENSG00000163939

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356770 ENSG00000163939 HEK293_OSMI2_2hA HEK293_TMG_2hB PBRM1 protein_coding protein_coding 18.29282 5.922628 32.63558 0.1142965 0.9894307 2.460144 6.9811234 4.6922023 10.463772 0.14949455 0.6018352 1.155373 0.51740417 0.79293333 0.32010000 -0.47283333 1.079686e-15 1.079686e-15 FALSE TRUE
ENST00000431678 ENSG00000163939 HEK293_OSMI2_2hA HEK293_TMG_2hB PBRM1 protein_coding protein_coding 18.29282 5.922628 32.63558 0.1142965 0.9894307 2.460144 0.9275598 0.0000000 2.766823 0.00000000 1.6710335 8.117291 0.02862500 0.00000000 0.08186667 0.08186667 3.793964e-01 1.079686e-15 FALSE FALSE
MSTRG.23059.2 ENSG00000163939 HEK293_OSMI2_2hA HEK293_TMG_2hB PBRM1 protein_coding   18.29282 5.922628 32.63558 0.1142965 0.9894307 2.460144 2.6649575 0.1956605 5.231147 0.17880943 0.4450861 4.671546 0.11258750 0.03340000 0.16126667 0.12786667 8.835925e-02 1.079686e-15 FALSE TRUE
MSTRG.23059.3 ENSG00000163939 HEK293_OSMI2_2hA HEK293_TMG_2hB PBRM1 protein_coding   18.29282 5.922628 32.63558 0.1142965 0.9894307 2.460144 2.0077207 0.2766610 2.393121 0.06319142 1.2282301 3.067492 0.09885417 0.04636667 0.07560000 0.02923333 1.000000e+00 1.079686e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163939 E001 123.3574672 0.0165605423 3.188988e-21 2.345280e-19 3 52545352 52545620 269 - 1.716 2.474 2.543
ENSG00000163939 E002 217.2896439 0.0141037700 3.002926e-20 1.973276e-18 3 52545621 52545873 253 - 2.010 2.672 2.211
ENSG00000163939 E003 369.4354304 0.0114640304 2.367266e-17 1.098925e-15 3 52545874 52546690 817 - 2.295 2.835 1.802
ENSG00000163939 E004 410.8039697 0.0027055102 4.384218e-14 1.311299e-12 3 52546691 52547840 1150 - 2.421 2.737 1.053
ENSG00000163939 E005 96.8280652 0.0040180163 5.688337e-04 2.417151e-03 3 52547841 52547989 149 - 1.814 2.075 0.876
ENSG00000163939 E006 35.5811854 0.0035681389 8.350522e-01 8.967691e-01 3 52547990 52547990 1 - 1.427 1.526 0.339
ENSG00000163939 E007 50.3109829 0.0015343777 8.429280e-01 9.021432e-01 3 52547991 52548009 19 - 1.573 1.669 0.328
ENSG00000163939 E008 44.7887863 0.0015308133 9.057424e-01 9.440429e-01 3 52548010 52548010 1 - 1.524 1.616 0.312
ENSG00000163939 E009 141.5334207 0.0004001251 6.518405e-01 7.626363e-01 3 52548011 52548164 154 - 2.015 2.117 0.343
ENSG00000163939 E010 55.7058374 0.0123127930 9.741654e-01 9.878797e-01 3 52548165 52548165 1 - 1.621 1.704 0.283
ENSG00000163939 E011 58.6077806 0.0104360662 8.596606e-01 9.134819e-01 3 52548166 52548172 7 - 1.641 1.736 0.322
ENSG00000163939 E012 76.0447813 0.0088358353 8.747948e-01 9.235340e-01 3 52548173 52548210 38 - 1.757 1.829 0.244
ENSG00000163939 E013 71.7278655 0.0033457862 3.600711e-01 5.043877e-01 3 52548211 52548235 25 - 1.741 1.771 0.101
ENSG00000163939 E014 152.9511623 0.0029686029 2.070942e-01 3.350492e-01 3 52550421 52550637 217 - 2.044 2.185 0.472
ENSG00000163939 E015 68.8587483 0.0064554136 7.890788e-02 1.577683e-01 3 52550747 52550817 71 - 1.689 1.884 0.660
ENSG00000163939 E016 49.0484164 0.0008488739 7.946243e-02 1.586778e-01 3 52554724 52554782 59 - 1.545 1.735 0.648
ENSG00000163939 E017 65.7462230 0.0105271963 8.175635e-01 8.846424e-01 3 52554783 52554879 97 - 1.690 1.796 0.357
ENSG00000163939 E018 40.2951299 0.0005459958 4.958176e-01 6.325590e-01 3 52558249 52558413 165 - 1.477 1.607 0.444
ENSG00000163939 E019 182.5271048 0.0003396600 9.064150e-01 9.445389e-01 3 52561767 52561968 202 - 2.130 2.220 0.300
ENSG00000163939 E020 100.8599297 0.0002801848 7.019723e-01 8.009066e-01 3 52563283 52563363 81 - 1.878 1.947 0.229
ENSG00000163939 E021 144.6490041 0.0006209120 1.588977e-01 2.736782e-01 3 52563364 52563474 111 - 2.018 2.157 0.463
ENSG00000163939 E022 75.4181309 0.0021620618 2.104749e-01 3.390950e-01 3 52563475 52563493 19 - 1.738 1.890 0.513
ENSG00000163939 E023 173.9136399 0.0002629327 1.348903e-01 2.409398e-01 3 52564050 52564233 184 - 2.098 2.234 0.453
ENSG00000163939 E024 141.4302043 0.0044116623 8.398345e-01 8.999814e-01 3 52576541 52576698 158 - 2.022 2.097 0.249
ENSG00000163939 E025 112.7564416 0.0013919505 6.545548e-02 1.358019e-01 3 52579054 52579199 146 - 1.940 1.939 -0.003
ENSG00000163939 E026 5.8147790 0.0253413934 5.353591e-02 1.154374e-01 3 52585473 52586424 952 - 0.646 1.011 1.436
ENSG00000163939 E027 45.2645008 0.0126689432 2.150975e-01 3.445595e-01 3 52586425 52586429 5 - 1.557 1.532 -0.085
ENSG00000163939 E028 152.0759753 0.0026258149 2.822893e-02 6.846697e-02 3 52586430 52586688 259 - 2.069 2.055 -0.048
ENSG00000163939 E029 85.2284340 0.0007215871 1.399815e-01 2.480017e-01 3 52587353 52587435 83 - 1.815 1.825 0.033
ENSG00000163939 E030 87.1772932 0.0005087015 1.261108e-01 2.287388e-01 3 52587436 52587510 75 - 1.826 1.835 0.030
ENSG00000163939 E031 140.5318676 0.0025764675 4.047698e-03 1.327473e-02 3 52589070 52589252 183 - 2.041 1.991 -0.167
ENSG00000163939 E032 43.8159094 0.0331153485 2.275535e-01 3.594690e-01 3 52589253 52589255 3 - 1.540 1.494 -0.157
ENSG00000163939 E033 152.6847816 0.0121780079 4.206172e-03 1.372029e-02 3 52603521 52603732 212 - 2.084 1.980 -0.351
ENSG00000163939 E034 0.8042123 0.1204513320 8.754930e-01 9.240363e-01 3 52609086 52609312 227 - 0.189 0.251 0.515
ENSG00000163939 E035 303.2532852 0.0003606833 5.922577e-17 2.616638e-15 3 52609313 52609955 643 - 2.390 2.226 -0.547
ENSG00000163939 E036 95.2200693 0.0013311742 2.301692e-04 1.092388e-03 3 52615351 52615456 106 - 1.882 1.772 -0.371
ENSG00000163939 E037 170.1278028 0.0054840623 1.569237e-05 9.970058e-05 3 52617262 52617538 277 - 2.137 1.995 -0.476
ENSG00000163939 E038 4.2854609 0.0524470104 9.578937e-01 9.776061e-01 3 52624897 52624941 45 - 0.618 0.687 0.296
ENSG00000163939 E039 103.7256715 0.0004781259 2.033398e-07 1.945857e-06 3 52627273 52627370 98 - 1.930 1.754 -0.593
ENSG00000163939 E040 116.1077866 0.0007656365 3.266363e-07 2.999092e-06 3 52628894 52629035 142 - 1.975 1.815 -0.541
ENSG00000163939 E041 134.0050828 0.0002721419 2.878137e-10 4.698443e-09 3 52634602 52634815 214 - 2.040 1.844 -0.656
ENSG00000163939 E042 80.9142285 0.0014298433 1.965168e-07 1.885612e-06 3 52641954 52642045 92 - 1.829 1.599 -0.778
ENSG00000163939 E043 78.0015474 0.0051142819 1.795107e-05 1.125340e-04 3 52643248 52643343 96 - 1.810 1.600 -0.714
ENSG00000163939 E044 61.4550233 0.0063105473 9.691453e-05 5.075936e-04 3 52644704 52644789 86 - 1.711 1.494 -0.738
ENSG00000163939 E045 71.8483856 0.0079355956 1.644191e-05 1.039850e-04 3 52648344 52648442 99 - 1.782 1.534 -0.841
ENSG00000163939 E046 55.6291794 0.0071200515 6.197330e-06 4.320548e-05 3 52651742 52651763 22 - 1.678 1.383 -1.010
ENSG00000163939 E047 69.9524835 0.0026463501 2.127564e-07 2.028897e-06 3 52651764 52651810 47 - 1.773 1.504 -0.914
ENSG00000163939 E048 88.8619219 0.0010971860 1.354021e-07 1.341186e-06 3 52658199 52658315 117 - 1.868 1.654 -0.723
ENSG00000163939 E049 97.4662292 0.0014931858 4.025880e-10 6.417797e-09 3 52662133 52662203 71 - 1.912 1.640 -0.922
ENSG00000163939 E050 102.3111210 0.0002857005 9.220217e-18 4.555927e-16 3 52662204 52662276 73 - 1.945 1.545 -1.356
ENSG00000163939 E051 70.9065999 0.0013240399 1.700808e-10 2.885661e-09 3 52668498 52668526 29 - 1.785 1.436 -1.188
ENSG00000163939 E052 101.0552017 0.0002986493 1.468429e-13 4.076037e-12 3 52668527 52668620 94 - 1.932 1.615 -1.072
ENSG00000163939 E053 67.1205051 0.0003802329 2.050425e-08 2.385597e-07 3 52668621 52668645 25 - 1.753 1.472 -0.956
ENSG00000163939 E054 104.9761325 0.0003029545 2.232267e-14 6.973883e-13 3 52678500 52678597 98 - 1.949 1.623 -1.099
ENSG00000163939 E055 59.8453569 0.0048710429 2.921687e-06 2.191665e-05 3 52679574 52679581 8 - 1.704 1.425 -0.952
ENSG00000163939 E056 54.1748897 0.0077258777 2.605908e-05 1.573286e-04 3 52679582 52679582 1 - 1.661 1.386 -0.940
ENSG00000163939 E057 74.1455253 0.0024655796 1.679457e-09 2.386320e-08 3 52679583 52679633 51 - 1.800 1.472 -1.116
ENSG00000163939 E058 72.7448899 0.0026702196 8.085099e-10 1.219990e-08 3 52679634 52679723 90 - 1.795 1.449 -1.177
ENSG00000163939 E059 25.3217446 0.0007991436 1.437527e-02 3.907915e-02 3 52679724 52679726 3 - 1.327 1.174 -0.540
ENSG00000163939 E060 1.3403442 0.0358192312 1.314920e-01 2.362239e-01 3 52681704 52681820 117 - 0.349 0.001 -9.840
ENSG00000163939 E061 31.3358689 0.0021199071 6.614459e-07 5.711698e-06 3 52682092 52682233 142 - 1.444 1.013 -1.529
ENSG00000163939 E062 4.5759452 0.0034323548 4.456719e-01 5.872127e-01 3 52684856 52684914 59 - 0.618 0.807 0.782
ENSG00000163939 E063 4.0722809 0.0417814450 2.801731e-01 4.199969e-01 3 52685436 52685748 313 - 0.556 0.808 1.065
ENSG00000163939 E064 37.1237376 0.0046911363 1.059152e-05 6.999204e-05 3 52685749 52685917 169 - 1.510 1.174 -1.170