ENSG00000163938

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000418458 ENSG00000163938 HEK293_OSMI2_2hA HEK293_TMG_2hB GNL3 protein_coding protein_coding 220.3511 104.1176 341.2203 7.599508 6.758989 1.712393 150.67858 80.303960 234.89940 5.4444541 7.8104752 1.548382 0.68439583 0.77250000 0.68803333 -0.084466667 0.0328668 7.509168e-29 FALSE  
ENST00000496254 ENSG00000163938 HEK293_OSMI2_2hA HEK293_TMG_2hB GNL3 protein_coding retained_intron 220.3511 104.1176 341.2203 7.599508 6.758989 1.712393 13.01826 4.979535 19.02134 0.4633174 0.4440377 1.931400 0.06085417 0.04766667 0.05576667 0.008100000 0.2764153 7.509168e-29 FALSE  
ENST00000497356 ENSG00000163938 HEK293_OSMI2_2hA HEK293_TMG_2hB GNL3 protein_coding retained_intron 220.3511 104.1176 341.2203 7.599508 6.758989 1.712393 30.14084 12.644453 38.73250 1.6410633 1.0483901 1.614272 0.14769583 0.12053333 0.11346667 -0.007066667 0.8263609 7.509168e-29    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163938 E001 0.1515154 4.322529e-02 1.000000e+00   3 52681156 52681275 120 + 0.079 0.001 -6.752
ENSG00000163938 E002 23.5419116 7.867864e-04 3.647673e-01 5.090990e-01 3 52685891 52686004 114 + 1.334 1.405 0.244
ENSG00000163938 E003 22.6769186 8.959033e-04 9.223019e-01 9.549787e-01 3 52686005 52686015 11 + 1.342 1.336 -0.021
ENSG00000163938 E004 37.5056487 3.792606e-03 9.511831e-01 9.734634e-01 3 52686016 52686029 14 + 1.553 1.550 -0.012
ENSG00000163938 E005 36.7693811 3.158030e-03 5.516317e-01 6.810448e-01 3 52686030 52686031 2 + 1.556 1.516 -0.136
ENSG00000163938 E006 199.1517082 2.244326e-04 3.052154e-29 4.798519e-27 3 52686032 52686047 16 + 2.352 1.994 -1.198
ENSG00000163938 E007 254.4447596 1.720206e-04 1.124826e-38 3.587457e-36 3 52686048 52686048 1 + 2.460 2.091 -1.231
ENSG00000163938 E008 699.9623446 5.439378e-04 1.205257e-21 9.229280e-20 3 52686049 52686105 57 + 2.862 2.679 -0.610
ENSG00000163938 E009 19.9463274 8.815466e-04 7.703437e-05 4.140240e-04 3 52686106 52686170 65 + 1.376 1.000 -1.338
ENSG00000163938 E010 15.7025949 1.114220e-03 8.346376e-04 3.382599e-03 3 52686171 52686176 6 + 1.274 0.925 -1.261
ENSG00000163938 E011 22.6205542 8.285590e-04 8.020667e-04 3.266950e-03 3 52686177 52686202 26 + 1.411 1.120 -1.023
ENSG00000163938 E012 28.4029938 6.158068e-02 1.486873e-02 4.019400e-02 3 52686203 52686425 223 + 1.513 1.180 -1.161
ENSG00000163938 E013 898.3675846 2.555284e-03 1.689258e-08 1.996412e-07 3 52686769 52686827 59 + 2.965 2.805 -0.533
ENSG00000163938 E014 4.7298280 1.454292e-02 1.981731e-02 5.109809e-02 3 52686828 52686955 128 + 0.819 0.414 -1.813
ENSG00000163938 E015 1445.8951376 2.935094e-03 6.027339e-09 7.755102e-08 3 52687246 52687383 138 + 3.173 3.008 -0.546
ENSG00000163938 E016 1341.1051156 2.621213e-03 4.723475e-07 4.198800e-06 3 52687502 52687615 114 + 3.133 2.996 -0.455
ENSG00000163938 E017 16.2167635 8.223279e-03 6.589871e-05 3.603392e-04 3 52687616 52687827 212 + 1.305 0.835 -1.716
ENSG00000163938 E018 1046.2259039 2.970975e-03 9.882710e-05 5.163687e-04 3 52688109 52688192 84 + 3.021 2.904 -0.388
ENSG00000163938 E019 27.0859884 7.764008e-03 8.483183e-02 1.671395e-01 3 52688193 52688206 14 + 1.456 1.304 -0.526
ENSG00000163938 E020 1.6167445 2.473281e-02 1.402833e-01 2.484109e-01 3 52688882 52688889 8 + 0.477 0.184 -1.916
ENSG00000163938 E021 2.5829676 2.734924e-02 1.336893e-01 2.392797e-01 3 52688890 52688924 35 + 0.602 0.314 -1.499
ENSG00000163938 E022 4.1403889 5.839596e-03 2.843277e-01 4.245599e-01 3 52688925 52689049 125 + 0.732 0.562 -0.731
ENSG00000163938 E023 4.1938724 3.162050e-02 5.704309e-01 6.969229e-01 3 52689050 52689073 24 + 0.716 0.621 -0.403
ENSG00000163938 E024 1098.6139163 4.993635e-04 7.480943e-05 4.033016e-04 3 52689074 52689206 133 + 3.028 2.965 -0.208
ENSG00000163938 E025 1141.6480393 1.045958e-04 9.134694e-04 3.661434e-03 3 52690592 52690704 113 + 3.038 2.999 -0.129
ENSG00000163938 E026 49.5098943 4.402805e-04 1.853705e-02 4.831184e-02 3 52690705 52690743 39 + 1.707 1.575 -0.450
ENSG00000163938 E027 132.0775303 2.491644e-04 1.872502e-04 9.090998e-04 3 52690744 52690944 201 + 2.129 1.998 -0.438
ENSG00000163938 E028 1370.3388781 2.640400e-04 9.714582e-04 3.861192e-03 3 52690945 52691071 127 + 3.118 3.077 -0.136
ENSG00000163938 E029 1033.3184026 4.875280e-04 4.924888e-02 1.078287e-01 3 52691542 52691629 88 + 2.973 3.006 0.109
ENSG00000163938 E030 1349.8998607 3.796189e-04 4.351005e-05 2.487131e-04 3 52692872 52693046 175 + 3.081 3.138 0.190
ENSG00000163938 E031 12.1927986 1.427176e-03 2.571417e-01 3.941895e-01 3 52693170 52693186 17 + 1.120 1.001 -0.436
ENSG00000163938 E032 440.4817000 2.096213e-04 3.067060e-08 3.445886e-07 3 52693187 52693190 4 + 2.578 2.685 0.356
ENSG00000163938 E033 1287.3995126 8.146801e-05 5.215759e-16 2.044930e-14 3 52693191 52693329 139 + 3.048 3.138 0.302
ENSG00000163938 E034 147.5562900 2.274117e-04 9.917276e-01 9.989159e-01 3 52693330 52693407 78 + 2.138 2.141 0.008
ENSG00000163938 E035 1657.9232076 5.639501e-05 1.572988e-11 3.171202e-10 3 52693408 52693544 137 + 3.166 3.232 0.220
ENSG00000163938 E036 2136.5746352 9.359350e-04 1.938684e-09 2.722391e-08 3 52693632 52693807 176 + 3.265 3.363 0.324
ENSG00000163938 E037 1321.6615504 2.483591e-03 5.489798e-08 5.864256e-07 3 52694037 52694103 67 + 3.040 3.183 0.476
ENSG00000163938 E038 794.6281157 2.079675e-03 2.285735e-07 2.167512e-06 3 52694193 52694200 8 + 2.822 2.959 0.456
ENSG00000163938 E039 1117.6836799 2.094031e-03 3.791457e-12 8.460309e-11 3 52694201 52694497 297 + 2.955 3.128 0.575