ENSG00000163932

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330452 ENSG00000163932 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCD protein_coding protein_coding 23.94662 33.70416 21.63087 0.4549453 0.2029372 -0.6395961 4.009623 4.831149 4.892958 0.5563926 0.8500820 0.01830301 0.1675208 0.1429667 0.2259000 0.08293333 2.584757e-01 2.65887e-13 FALSE TRUE
ENST00000394729 ENSG00000163932 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCD protein_coding protein_coding 23.94662 33.70416 21.63087 0.4549453 0.2029372 -0.6395961 3.050036 1.896177 6.083011 0.2841580 0.4806939 1.67647297 0.1298667 0.0564000 0.2808333 0.22443333 2.658870e-13 2.65887e-13 FALSE TRUE
ENST00000654719 ENSG00000163932 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKCD protein_coding protein_coding 23.94662 33.70416 21.63087 0.4549453 0.2029372 -0.6395961 16.075484 26.387471 9.681141 0.3127330 1.0451353 -1.44566135 0.6658417 0.7831667 0.4485000 -0.33466667 1.685400e-06 2.65887e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163932 E001 0.0000000       3 53156009 53156199 191 +      
ENSG00000163932 E002 0.0000000       3 53156339 53156484 146 +      
ENSG00000163932 E003 0.0000000       3 53161120 53161208 89 +      
ENSG00000163932 E004 0.0000000       3 53161209 53161216 8 +      
ENSG00000163932 E005 0.8836079 0.0130565825 1.101260e-03 4.307251e-03 3 53161217 53161220 4 + 0.553 0.000 -12.521
ENSG00000163932 E006 13.9637087 0.0095924225 4.330424e-10 6.859987e-09 3 53161221 53161240 20 + 1.460 0.827 -2.286
ENSG00000163932 E007 31.7901478 0.0035237444 9.487549e-24 9.151668e-22 3 53161241 53161355 115 + 1.820 1.127 -2.395
ENSG00000163932 E008 40.3804692 0.0009294070 7.213254e-20 4.499802e-18 3 53161356 53161428 73 + 1.861 1.348 -1.751
ENSG00000163932 E009 0.4031496 0.0259721350 3.879657e-01 5.320766e-01 3 53161521 53161575 55 + 0.000 0.175 10.954
ENSG00000163932 E010 16.2486046 0.0011031145 1.135524e-03 4.423003e-03 3 53165104 53165128 25 + 1.375 1.101 -0.968
ENSG00000163932 E011 32.6813229 0.0018228639 8.369305e-03 2.471112e-02 3 53165129 53165215 87 + 1.611 1.442 -0.580
ENSG00000163932 E012 0.2987644 0.0272437592 9.111607e-02   3 53168741 53168796 56 + 0.269 0.000 -13.021
ENSG00000163932 E013 0.1515154 0.0435893528 2.903808e-01   3 53168797 53168811 15 + 0.155 0.000 -11.914
ENSG00000163932 E014 0.0000000       3 53168812 53168820 9 +      
ENSG00000163932 E015 0.0000000       3 53173493 53173526 34 +      
ENSG00000163932 E016 0.9578015 0.1976309697 4.844565e-01 6.224560e-01 3 53173527 53173608 82 + 0.155 0.304 1.244
ENSG00000163932 E017 118.9769432 0.0010495272 9.469243e-08 9.654592e-07 3 53178404 53178537 134 + 2.171 1.979 -0.644
ENSG00000163932 E018 223.0125088 0.0003422876 1.586801e-04 7.859004e-04 3 53179577 53179776 200 + 2.384 2.286 -0.326
ENSG00000163932 E019 136.6986139 0.0014168097 2.551173e-01 3.919393e-01 3 53181207 53181259 53 + 2.136 2.092 -0.148
ENSG00000163932 E020 107.8728026 0.0003250366 4.156900e-01 5.590546e-01 3 53181260 53181267 8 + 2.027 1.995 -0.107
ENSG00000163932 E021 255.9357574 0.0002341670 2.074581e-01 3.354556e-01 3 53181444 53181606 163 + 2.402 2.370 -0.107
ENSG00000163932 E022 140.2647930 0.0042024201 1.395954e-01 2.474715e-01 3 53181701 53181732 32 + 2.167 2.100 -0.225
ENSG00000163932 E023 195.8550640 0.0003816749 3.641108e-01 5.085123e-01 3 53183121 53183206 86 + 2.286 2.259 -0.090
ENSG00000163932 E024 0.8824620 0.2152301799 6.026090e-02 1.270547e-01 3 53183343 53183451 109 + 0.497 0.095 -3.131
ENSG00000163932 E025 248.8872965 0.0002120498 9.718187e-01 9.863975e-01 3 53183452 53183581 130 + 2.373 2.370 -0.012
ENSG00000163932 E026 229.4812079 0.0006478202 7.665737e-01 8.490417e-01 3 53184874 53184974 101 + 2.332 2.337 0.018
ENSG00000163932 E027 245.3212222 0.0001817063 3.541050e-01 4.983740e-01 3 53185604 53185700 97 + 2.351 2.370 0.064
ENSG00000163932 E028 252.9189588 0.0001800295 2.687165e-02 6.572786e-02 3 53185927 53186027 101 + 2.342 2.391 0.165
ENSG00000163932 E029 293.8202262 0.0005577080 4.172729e-01 5.606342e-01 3 53186167 53186340 174 + 2.430 2.446 0.054
ENSG00000163932 E030 242.8597108 0.0026373415 8.355307e-01 8.971354e-01 3 53186604 53186695 92 + 2.366 2.355 -0.036
ENSG00000163932 E031 211.6511620 0.0002267632 2.093521e-01 3.377657e-01 3 53187340 53187402 63 + 2.278 2.307 0.099
ENSG00000163932 E032 281.4109980 0.0001775877 2.630492e-02 6.456002e-02 3 53188720 53188858 139 + 2.390 2.437 0.157
ENSG00000163932 E033 330.5912073 0.0002125712 8.814788e-04 3.549409e-03 3 53189058 53189246 189 + 2.446 2.514 0.224
ENSG00000163932 E034 347.1055665 0.0002041388 3.924105e-05 2.266423e-04 3 53189873 53190001 129 + 2.457 2.539 0.273
ENSG00000163932 E035 469.4239703 0.0001739579 4.047490e-11 7.622117e-10 3 53192108 53192717 610 + 2.564 2.678 0.380