ENSG00000163918

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296273 ENSG00000163918 HEK293_OSMI2_2hA HEK293_TMG_2hB RFC4 protein_coding protein_coding 42.16638 31.24803 45.7109 2.631016 0.5895588 0.5486269 17.952156 13.241721 22.47897 1.7550581 0.5035045 0.7630379 0.4218167 0.4206000 0.4919 0.07130000 0.1551814901 0.0001436096 FALSE  
ENST00000392481 ENSG00000163918 HEK293_OSMI2_2hA HEK293_TMG_2hB RFC4 protein_coding protein_coding 42.16638 31.24803 45.7109 2.631016 0.5895588 0.5486269 9.847858 9.343996 10.53858 0.3231221 0.9697221 0.1733939 0.2402458 0.3019000 0.2307 -0.07120000 0.2285689836 0.0001436096 FALSE  
ENST00000479307 ENSG00000163918 HEK293_OSMI2_2hA HEK293_TMG_2hB RFC4 protein_coding retained_intron 42.16638 31.24803 45.7109 2.631016 0.5895588 0.5486269 8.609112 5.782027 5.04726 0.8248085 0.1662900 -0.1957123 0.2059958 0.1832667 0.1104 -0.07286667 0.0001436096 0.0001436096 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163918 E001 0.1515154 0.0423479240 5.916058e-01   3 186789880 186789891 12 - 0.112 0.000 -8.585
ENSG00000163918 E002 0.8178402 0.0358499379 1.203439e-01 2.204683e-01 3 186789892 186789894 3 - 0.112 0.387 2.292
ENSG00000163918 E003 1.5614842 0.2591381112 3.628005e-01 5.072209e-01 3 186789895 186789899 5 - 0.275 0.533 1.452
ENSG00000163918 E004 4.5004951 0.0493055198 1.914924e-01 3.156034e-01 3 186789900 186789902 3 - 0.626 0.849 0.909
ENSG00000163918 E005 121.0017511 0.0014717117 1.185621e-04 6.072761e-04 3 186789903 186790035 133 - 2.010 2.151 0.475
ENSG00000163918 E006 79.4675603 0.0003860971 2.408948e-03 8.488906e-03 3 186790036 186790039 4 - 1.841 1.962 0.405
ENSG00000163918 E007 113.3646544 0.0018869185 2.711948e-04 1.262521e-03 3 186790040 186790060 21 - 1.984 2.126 0.474
ENSG00000163918 E008 103.0038678 0.0025745120 7.850098e-04 3.205893e-03 3 186790061 186790064 4 - 1.942 2.085 0.478
ENSG00000163918 E009 31.7599544 0.0006313658 3.665992e-05 2.132364e-04 3 186790065 186790141 77 - 1.367 1.625 0.883
ENSG00000163918 E010 246.6215818 0.0018600992 6.721278e-05 3.666674e-04 3 186790142 186790255 114 - 2.330 2.451 0.403
ENSG00000163918 E011 35.6689380 0.0006747539 1.166962e-01 2.152464e-01 3 186790256 186790325 70 - 1.514 1.606 0.312
ENSG00000163918 E012 259.9712963 0.0010552669 4.351532e-02 9.749224e-02 3 186790326 186790406 81 - 2.387 2.441 0.182
ENSG00000163918 E013 14.6873203 0.0212037974 1.122546e-02 3.170630e-02 3 186791323 186791689 367 - 1.321 1.029 -1.040
ENSG00000163918 E014 27.8622395 0.0007278805 8.740241e-01 9.230218e-01 3 186791690 186791724 35 - 1.465 1.454 -0.039
ENSG00000163918 E015 356.9209763 0.0003912134 7.817609e-01 8.598149e-01 3 186791725 186791850 126 - 2.553 2.548 -0.017
ENSG00000163918 E016 225.1111810 0.0021694721 2.010360e-01 3.274637e-01 3 186792490 186792521 32 - 2.369 2.331 -0.129
ENSG00000163918 E017 240.5739684 0.0030128520 6.193384e-02 1.298752e-01 3 186792522 186792549 28 - 2.408 2.349 -0.196
ENSG00000163918 E018 296.1811937 0.0010072878 2.318467e-01 3.646517e-01 3 186792550 186792610 61 - 2.483 2.454 -0.094
ENSG00000163918 E019 379.9478149 0.0001867155 6.717831e-01 7.779269e-01 3 186792804 186792947 144 - 2.574 2.582 0.025
ENSG00000163918 E020 156.7902196 0.0002688385 2.219690e-03 7.904986e-03 3 186794658 186794665 8 - 2.152 2.238 0.289
ENSG00000163918 E021 180.1112986 0.0002695113 1.063468e-01 2.001518e-01 3 186794666 186794698 33 - 2.235 2.277 0.142
ENSG00000163918 E022 216.9986573 0.0008536303 9.782303e-01 9.905119e-01 3 186794699 186794777 79 - 2.336 2.336 -0.001
ENSG00000163918 E023 1.5092599 0.0457138327 9.959218e-01 1.000000e+00 3 186794778 186794781 4 - 0.392 0.389 -0.017
ENSG00000163918 E024 1.7799132 0.0076183084 4.070286e-02 9.232802e-02 3 186794782 186794859 78 - 0.595 0.236 -2.025
ENSG00000163918 E025 136.3221698 0.0003780060 9.718008e-02 1.861694e-01 3 186797535 186797538 4 - 2.160 2.108 -0.175
ENSG00000163918 E026 197.4823232 0.0012439387 4.168185e-01 5.601905e-01 3 186797539 186797614 76 - 2.309 2.284 -0.084
ENSG00000163918 E027 199.6747895 0.0016595848 8.130511e-01 8.814543e-01 3 186801117 186801195 79 - 2.298 2.303 0.019
ENSG00000163918 E028 1.7265419 0.0090375352 6.659575e-02 1.377211e-01 3 186801196 186801457 262 - 0.561 0.236 -1.870
ENSG00000163918 E029 268.2550718 0.0018145413 1.439635e-02 3.912586e-02 3 186804583 186804724 142 - 2.462 2.390 -0.239
ENSG00000163918 E030 7.4170884 0.0205737458 6.355980e-02 1.326227e-01 3 186804725 186804880 156 - 1.029 0.782 -0.937
ENSG00000163918 E031 3.0406464 0.0059109904 7.043822e-02 1.440747e-01 3 186805560 186805598 39 - 0.733 0.448 -1.288
ENSG00000163918 E032 153.8197274 0.0004780082 1.344599e-08 1.618363e-07 3 186806290 186806396 107 - 2.262 2.090 -0.575
ENSG00000163918 E033 90.2839048 0.0002985316 5.839514e-09 7.534929e-08 3 186806397 186806424 28 - 2.053 1.831 -0.747
ENSG00000163918 E034 128.3557674 0.0002582607 2.796070e-08 3.166779e-07 3 186806425 186806695 271 - 2.188 2.010 -0.595
ENSG00000163918 E035 3.4893063 0.0047392944 6.795995e-03 2.069273e-02 3 186806748 186807058 311 - 0.392 0.807 1.884