ENSG00000163904

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296257 ENSG00000163904 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP2 protein_coding protein_coding 23.50481 11.32578 33.3572 1.437362 1.19864 1.557547 7.0621576 6.8906840 8.080389 1.0580187 0.3711708 0.2294698 0.40892500 0.60543333 0.2422667 -0.36316667 4.404633e-10 4.404633e-10 FALSE TRUE
ENST00000444509 ENSG00000163904 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP2 protein_coding protein_coding 23.50481 11.32578 33.3572 1.437362 1.19864 1.557547 0.2927962 0.7892593 0.000000 0.7892593 0.0000000 -6.3205916 0.02613333 0.06673333 0.0000000 -0.06673333 6.335309e-01 4.404633e-10 FALSE FALSE
ENST00000483005 ENSG00000163904 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP2 protein_coding retained_intron 23.50481 11.32578 33.3572 1.437362 1.19864 1.557547 4.2518248 0.7933174 6.481022 0.6214839 1.0148114 3.0144037 0.13775417 0.06370000 0.1941667 0.13046667 3.508932e-01 4.404633e-10 FALSE FALSE
MSTRG.24214.10 ENSG00000163904 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP2 protein_coding   23.50481 11.32578 33.3572 1.437362 1.19864 1.557547 0.3403295 0.8981210 0.000000 0.5513827 0.0000000 -6.5048127 0.03183333 0.09586667 0.0000000 -0.09586667 9.927587e-02 4.404633e-10 TRUE TRUE
MSTRG.24214.11 ENSG00000163904 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP2 protein_coding   23.50481 11.32578 33.3572 1.437362 1.19864 1.557547 4.6553131 0.2937758 9.507818 0.2937758 0.1644803 4.9695517 0.14079167 0.02170000 0.2857667 0.26406667 1.851718e-02 4.404633e-10 FALSE FALSE
MSTRG.24214.3 ENSG00000163904 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP2 protein_coding   23.50481 11.32578 33.3572 1.437362 1.19864 1.557547 2.8482814 1.2103546 4.386683 0.3891507 0.8250767 1.8491150 0.10370417 0.11100000 0.1306000 0.01960000 8.215405e-01 4.404633e-10 FALSE TRUE
MSTRG.24214.5 ENSG00000163904 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP2 protein_coding   23.50481 11.32578 33.3572 1.437362 1.19864 1.557547 2.5380594 0.3452432 3.269901 0.3452432 0.4181645 3.2067734 0.07906667 0.02553333 0.0978000 0.07226667 1.555748e-01 4.404633e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163904 E001 0.0000000       3 185582496 185582783 288 +      
ENSG00000163904 E002 0.0000000       3 185582784 185582817 34 +      
ENSG00000163904 E003 0.0000000       3 185582818 185582863 46 +      
ENSG00000163904 E004 1.8780574 0.0077533706 1.303059e-01 2.345859e-01 3 185586241 185586258 18 + 0.534 0.273 -1.463
ENSG00000163904 E005 2.4682114 0.0083859878 1.229964e-01 2.242364e-01 3 185586259 185586294 36 + 0.617 0.364 -1.257
ENSG00000163904 E006 2.4682114 0.0083859878 1.229964e-01 2.242364e-01 3 185586295 185586297 3 + 0.617 0.364 -1.257
ENSG00000163904 E007 3.9440601 0.0039503826 3.607430e-01 5.050940e-01 3 185586298 185586310 13 + 0.728 0.609 -0.504
ENSG00000163904 E008 5.3520423 0.0029739190 3.719867e-01 5.164583e-01 3 185586311 185586321 11 + 0.833 0.731 -0.405
ENSG00000163904 E009 87.0638627 0.0035031296 4.441682e-03 1.437686e-02 3 185586322 185586514 193 + 1.979 1.863 -0.390
ENSG00000163904 E010 86.5753904 0.0043906839 2.217241e-04 1.056835e-03 3 185590114 185590169 56 + 1.994 1.829 -0.554
ENSG00000163904 E011 0.5964967 0.0219730766 6.252692e-01 7.414397e-01 3 185598394 185598411 18 + 0.237 0.158 -0.729
ENSG00000163904 E012 107.2156045 0.0008054767 5.102595e-04 2.197986e-03 3 185598412 185598545 134 + 2.068 1.962 -0.356
ENSG00000163904 E013 47.8462987 0.0005969011 6.690126e-03 2.042026e-02 3 185598958 185598964 7 + 1.728 1.607 -0.412
ENSG00000163904 E014 57.6376186 0.0004322054 2.658395e-03 9.248299e-03 3 185598965 185598991 27 + 1.807 1.684 -0.415
ENSG00000163904 E015 68.3205222 0.0041090856 3.367923e-03 1.134520e-02 3 185598992 185599024 33 + 1.882 1.744 -0.465
ENSG00000163904 E016 1.2471304 0.2360750025 5.985977e-01 7.201550e-01 3 185599025 185599029 5 + 0.389 0.274 -0.717
ENSG00000163904 E017 91.4180589 0.0007600165 9.453446e-04 3.772596e-03 3 185600765 185600855 91 + 1.999 1.890 -0.367
ENSG00000163904 E018 157.9800789 0.0002716201 1.187054e-04 6.079422e-04 3 185606330 185606498 169 + 2.227 2.136 -0.302
ENSG00000163904 E019 1.1071294 0.0869977373 2.307957e-01 3.634181e-01 3 185609003 185609246 244 + 0.389 0.159 -1.717
ENSG00000163904 E020 165.5387653 0.0006593565 1.638392e-07 1.597470e-06 3 185609247 185609350 104 + 2.263 2.125 -0.462
ENSG00000163904 E021 0.8857980 0.0136968632 3.861818e-02 8.848049e-02 3 185611528 185611650 123 + 0.389 0.000 -10.578
ENSG00000163904 E022 164.0952930 0.0004739441 2.454081e-07 2.312221e-06 3 185611651 185611745 95 + 2.257 2.125 -0.442
ENSG00000163904 E023 0.2934659 0.0290773554 6.929780e-01   3 185612222 185612606 385 + 0.094 0.158 0.856
ENSG00000163904 E024 129.1867954 0.0002815107 7.055237e-06 4.854867e-05 3 185612607 185612658 52 + 2.151 2.026 -0.417
ENSG00000163904 E025 98.2126855 0.0004207438 5.831440e-06 4.089088e-05 3 185613345 185613354 10 + 2.040 1.890 -0.504
ENSG00000163904 E026 120.6318220 0.0002963441 3.219688e-09 4.344755e-08 3 185613355 185613408 54 + 2.139 1.958 -0.607
ENSG00000163904 E027 0.6299079 0.0236529958 6.274996e-01 7.432982e-01 3 185613409 185613644 236 + 0.237 0.158 -0.727
ENSG00000163904 E028 0.9619567 0.3171529313 4.635685e-01 6.033448e-01 3 185614503 185614563 61 + 0.344 0.161 -1.434
ENSG00000163904 E029 199.2029507 0.0002519806 7.400348e-05 3.993203e-04 3 185614564 185614740 177 + 2.324 2.243 -0.270
ENSG00000163904 E030 148.5743577 0.0002442563 1.779022e-01 2.985053e-01 3 185617480 185617611 132 + 2.176 2.159 -0.056
ENSG00000163904 E031 179.8484398 0.0002758506 1.942141e-01 3.190522e-01 3 185619299 185619502 204 + 2.228 2.286 0.194
ENSG00000163904 E032 0.2998086 0.0291293582 6.941432e-01   3 185619503 185619519 17 + 0.094 0.158 0.855
ENSG00000163904 E033 107.5656798 0.0002937467 1.556120e-02 4.175728e-02 3 185621826 185621905 80 + 1.984 2.091 0.356
ENSG00000163904 E034 124.6650605 0.0002840276 1.197213e-01 2.195756e-01 3 185623998 185624082 85 + 2.063 2.136 0.245
ENSG00000163904 E035 143.6157508 0.0018367518 1.889030e-01 3.123766e-01 3 185626298 185626393 96 + 2.125 2.195 0.234
ENSG00000163904 E036 1.0987104 0.0788065072 2.290491e-01 3.612955e-01 3 185628527 185628600 74 + 0.389 0.159 -1.716
ENSG00000163904 E037 769.2723949 0.0005346809 2.568004e-27 3.421242e-25 3 185629782 185632377 2596 + 2.801 2.977 0.586
ENSG00000163904 E038 65.5944339 0.0110212668 4.004715e-03 1.315533e-02 3 185632378 185632667 290 + 1.718 1.939 0.746
ENSG00000163904 E039 183.5566935 0.0059866047 9.393712e-17 4.059330e-15 3 185632668 185633551 884 + 2.058 2.452 1.317