ENSG00000163882

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000429568 ENSG00000163882 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR2H protein_coding protein_coding 124.5579 181.3028 81.44104 8.245143 1.525063 -1.154476 21.174761 34.772632 10.409855 3.7983216 1.820086 -1.7390319 0.16293750 0.19096667 0.12720000 -0.06376667 1.704373e-01 4.698531e-14 FALSE  
ENST00000452961 ENSG00000163882 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR2H protein_coding protein_coding 124.5579 181.3028 81.44104 8.245143 1.525063 -1.154476 18.577079 27.427231 11.116060 4.8956273 2.043376 -1.3021921 0.14556667 0.14946667 0.13653333 -0.01293333 8.849830e-01 4.698531e-14 FALSE  
ENST00000455712 ENSG00000163882 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR2H protein_coding protein_coding 124.5579 181.3028 81.44104 8.245143 1.525063 -1.154476 58.657998 91.370522 37.016453 1.1967000 1.325352 -1.3033303 0.46876250 0.50583333 0.45506667 -0.05076667 5.001570e-01 4.698531e-14 FALSE  
ENST00000488213 ENSG00000163882 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR2H protein_coding retained_intron 124.5579 181.3028 81.44104 8.245143 1.525063 -1.154476 8.226184 6.442691 7.684897 0.3243292 0.533357 0.2540009 0.07199167 0.03556667 0.09423333 0.05866667 4.698531e-14 4.698531e-14 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163882 E001 0.4502799 0.0285490199 1.182855e-02 3.312076e-02 3 184361710 184361722 13 + 0.404 0.000 -11.374
ENSG00000163882 E002 6.5562176 0.0155275409 3.174364e-03 1.078001e-02 3 184361723 184361788 66 + 1.069 0.694 -1.445
ENSG00000163882 E003 73.2547640 0.0064115103 1.119268e-05 7.353124e-05 3 184361789 184362146 358 + 1.973 1.735 -0.804
ENSG00000163882 E004 10.8708632 0.1184910529 4.479768e-02 9.983280e-02 3 184362443 184362504 62 + 1.239 0.892 -1.265
ENSG00000163882 E005 3.9490534 0.0038906268 1.277466e-02 3.538550e-02 3 184362615 184362724 110 + 0.883 0.542 -1.420
ENSG00000163882 E006 32.6854295 0.0154723647 1.223743e-03 4.721008e-03 3 184362873 184363001 129 + 1.643 1.378 -0.908
ENSG00000163882 E007 35.2532187 0.0357984163 1.422333e-01 2.510794e-01 3 184363002 184363115 114 + 1.610 1.452 -0.543
ENSG00000163882 E008 53.6471052 0.0218964906 6.123018e-02 1.287045e-01 3 184363116 184363225 110 + 1.784 1.630 -0.520
ENSG00000163882 E009 80.1411649 0.0021073941 1.416135e-04 7.104939e-04 3 184363226 184363360 135 + 1.961 1.798 -0.549
ENSG00000163882 E010 245.2806798 0.0013958701 2.844303e-01 4.246684e-01 3 184363361 184363402 42 + 2.292 2.340 0.161
ENSG00000163882 E011 454.3676857 0.0035666557 8.479494e-01 9.055796e-01 3 184363403 184363433 31 + 2.590 2.598 0.025
ENSG00000163882 E012 1001.5373729 0.0009006985 1.825868e-01 3.044592e-01 3 184363434 184363565 132 + 2.946 2.937 -0.028
ENSG00000163882 E013 20.1095398 0.0224016803 2.220235e-05 1.362234e-04 3 184363566 184363574 9 + 1.540 1.110 -1.504
ENSG00000163882 E014 94.0007101 0.0004362650 8.960617e-35 2.170795e-32 3 184364451 184364954 504 + 2.200 1.758 -1.483
ENSG00000163882 E015 26.6457608 0.0016419852 3.067683e-09 4.153541e-08 3 184364955 184364965 11 + 1.638 1.245 -1.356
ENSG00000163882 E016 812.0289153 0.0003809103 5.367339e-01 6.684501e-01 3 184364966 184365006 41 + 2.845 2.851 0.021
ENSG00000163882 E017 813.0996976 0.0004228928 5.050583e-01 6.408864e-01 3 184365007 184365049 43 + 2.846 2.851 0.017
ENSG00000163882 E018 28.2555912 0.0137675656 9.760563e-06 6.506138e-05 3 184365050 184365132 83 + 1.643 1.281 -1.249
ENSG00000163882 E019 1230.1167762 0.0008170333 2.482650e-01 3.838837e-01 3 184365133 184365226 94 + 3.004 3.038 0.115
ENSG00000163882 E020 28.0730522 0.0156398827 1.845491e-07 1.780520e-06 3 184365227 184365523 297 + 1.687 1.248 -1.512
ENSG00000163882 E021 9.6341491 0.0186292142 2.196701e-03 7.831801e-03 3 184366515 184366716 202 + 1.213 0.867 -1.271
ENSG00000163882 E022 1188.8163653 0.0014294446 1.652389e-01 2.819888e-01 3 184366717 184366800 84 + 2.982 3.025 0.145
ENSG00000163882 E023 124.6982118 0.0003365315 4.487163e-09 5.899149e-08 3 184368113 184368176 64 + 1.842 2.093 0.841
ENSG00000163882 E024 1648.8519490 0.0015609724 1.190995e-06 9.731318e-06 3 184368177 184368596 420 + 3.075 3.181 0.353