ENSG00000163875

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373073 ENSG00000163875 HEK293_OSMI2_2hA HEK293_TMG_2hB MEAF6 protein_coding protein_coding 46.49824 35.37721 68.57688 6.216758 2.503105 0.9547047 8.537872 2.930482 16.141871 0.04515129 4.00919869 2.4575766 0.16693333 0.08713333 0.23200000 0.14486667 1.351229e-02 1.292385e-11 FALSE TRUE
ENST00000373074 ENSG00000163875 HEK293_OSMI2_2hA HEK293_TMG_2hB MEAF6 protein_coding protein_coding 46.49824 35.37721 68.57688 6.216758 2.503105 0.9547047 4.963577 4.319166 6.843351 0.87604425 0.19481274 0.6627206 0.10804167 0.12243333 0.10026667 -0.02216667 5.764254e-01 1.292385e-11 FALSE FALSE
ENST00000373075 ENSG00000163875 HEK293_OSMI2_2hA HEK293_TMG_2hB MEAF6 protein_coding protein_coding 46.49824 35.37721 68.57688 6.216758 2.503105 0.9547047 3.761355 5.373644 4.034340 1.30432572 0.09469459 -0.4126785 0.08780417 0.14873333 0.05893333 -0.08980000 1.292385e-11 1.292385e-11 FALSE TRUE
ENST00000475828 ENSG00000163875 HEK293_OSMI2_2hA HEK293_TMG_2hB MEAF6 protein_coding processed_transcript 46.49824 35.37721 68.57688 6.216758 2.503105 0.9547047 21.929824 17.797427 28.738541 3.11957801 0.99848367 0.6910096 0.48113333 0.50366667 0.42126667 -0.08240000 3.838203e-01 1.292385e-11 TRUE TRUE
MSTRG.858.6 ENSG00000163875 HEK293_OSMI2_2hA HEK293_TMG_2hB MEAF6 protein_coding   46.49824 35.37721 68.57688 6.216758 2.503105 0.9547047 4.201429 2.821968 8.275369 0.86262130 0.92626096 1.5487612 0.08867083 0.07646667 0.12140000 0.04493333 1.935282e-01 1.292385e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163875 E001 31.198697 0.0288932838 5.414887e-01 6.724698e-01 1 37489993 37492574 2582 - 1.531 1.502 -0.100
ENSG00000163875 E002 107.258466 0.0016543611 2.203060e-12 5.112237e-11 1 37492575 37493310 736 - 1.892 2.167 0.924
ENSG00000163875 E003 43.234371 0.0059827362 8.785110e-11 1.565675e-09 1 37493311 37493334 24 - 1.395 1.829 1.478
ENSG00000163875 E004 87.544696 0.0003634353 2.156156e-14 6.752805e-13 1 37493335 37493397 63 - 1.796 2.087 0.978
ENSG00000163875 E005 142.607342 0.0015575325 5.000074e-09 6.525552e-08 1 37493398 37493466 69 - 2.059 2.259 0.671
ENSG00000163875 E006 525.700665 0.0013065656 1.679183e-03 6.216243e-03 1 37493467 37493761 295 - 2.697 2.759 0.209
ENSG00000163875 E007 282.067958 0.0016508379 3.274059e-01 4.708612e-01 1 37493762 37493814 53 - 2.446 2.475 0.095
ENSG00000163875 E008 323.351759 0.0007511250 2.633692e-01 4.012541e-01 1 37493815 37493933 119 - 2.508 2.533 0.083
ENSG00000163875 E009 406.224244 0.0003954875 7.042137e-01 8.028015e-01 1 37493934 37494107 174 - 2.614 2.619 0.017
ENSG00000163875 E010 2.802362 0.0054408044 1.679693e-01 2.855591e-01 1 37495874 37495884 11 - 0.675 0.454 -1.018
ENSG00000163875 E011 217.805679 0.0002771805 2.499893e-01 3.858947e-01 1 37495885 37495918 34 - 2.360 2.331 -0.095
ENSG00000163875 E012 38.750575 0.0005725698 3.761135e-01 5.204866e-01 1 37496547 37496604 58 - 1.580 1.630 0.168
ENSG00000163875 E013 6.085996 0.0144209456 1.316760e-01 2.364743e-01 1 37496707 37496736 30 - 0.942 0.734 -0.811
ENSG00000163875 E014 22.451772 0.0013906852 5.719996e-03 1.787146e-02 1 37501415 37501803 389 - 1.460 1.254 -0.717
ENSG00000163875 E015 399.558798 0.0003216368 1.319392e-03 5.041850e-03 1 37501804 37501996 193 - 2.638 2.576 -0.206
ENSG00000163875 E016 218.045707 0.0028402148 2.718613e-02 6.637109e-02 1 37509278 37509323 46 - 2.385 2.298 -0.292
ENSG00000163875 E017 318.109246 0.0028535128 2.074967e-03 7.456302e-03 1 37509455 37509542 88 - 2.557 2.449 -0.359
ENSG00000163875 E018 357.269712 0.0011572890 8.883449e-07 7.459522e-06 1 37513423 37513538 116 - 2.615 2.491 -0.414
ENSG00000163875 E019 3.512682 0.0045174352 2.588807e-01 3.962076e-01 1 37513539 37514269 731 - 0.725 0.554 -0.739
ENSG00000163875 E020 1.064280 0.0119865820 4.126388e-01 5.561948e-01 1 37514517 37514656 140 - 0.387 0.240 -0.961
ENSG00000163875 E021 222.859212 0.0012813967 7.067189e-07 6.062569e-06 1 37514657 37514766 110 - 2.421 2.271 -0.498