ENSG00000163872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305135 ENSG00000163872 HEK293_OSMI2_2hA HEK293_TMG_2hB YEATS2 protein_coding protein_coding 13.28437 12.75178 12.79104 0.4588808 0.4793789 0.004431477 3.608578 1.527264 4.9600034 0.5418695 1.0703143 1.6928823 0.2781250 0.12233333 0.3948000 0.27246667 8.375712e-02 1.79071e-16 FALSE TRUE
ENST00000432781 ENSG00000163872 HEK293_OSMI2_2hA HEK293_TMG_2hB YEATS2 protein_coding protein_coding 13.28437 12.75178 12.79104 0.4588808 0.4793789 0.004431477 1.307970 1.733622 2.0615932 0.1282156 0.1338146 0.2486538 0.1005917 0.13626667 0.1622333 0.02596667 6.547452e-01 1.79071e-16 FALSE TRUE
ENST00000468850 ENSG00000163872 HEK293_OSMI2_2hA HEK293_TMG_2hB YEATS2 protein_coding retained_intron 13.28437 12.75178 12.79104 0.4588808 0.4793789 0.004431477 1.614742 4.219552 0.0000000 0.9641166 0.0000000 -8.7243610 0.1255875 0.32740000 0.0000000 -0.32740000 1.790710e-16 1.79071e-16 FALSE FALSE
MSTRG.24145.2 ENSG00000163872 HEK293_OSMI2_2hA HEK293_TMG_2hB YEATS2 protein_coding   13.28437 12.75178 12.79104 0.4588808 0.4793789 0.004431477 1.796990 0.501608 2.0019578 0.5016080 0.1945209 1.9754893 0.1250292 0.04233333 0.1568667 0.11453333 1.322529e-01 1.79071e-16 FALSE TRUE
MSTRG.24145.6 ENSG00000163872 HEK293_OSMI2_2hA HEK293_TMG_2hB YEATS2 protein_coding   13.28437 12.75178 12.79104 0.4588808 0.4793789 0.004431477 2.381235 2.857686 0.9593525 0.1781344 0.9593525 -1.5647936 0.1701625 0.22520000 0.0698000 -0.15540000 1.304710e-01 1.79071e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163872 E001 0.7469680 0.0198732757 2.640979e-02 6.476623e-02 3 183697797 183697805 9 + 0.385 0.000 -16.113
ENSG00000163872 E002 16.5436947 0.0022801292 1.369417e-05 8.812523e-05 3 183697806 183697993 188 + 1.371 1.028 -1.219
ENSG00000163872 E003 0.9493850 0.2386268205 2.506272e-01 3.866874e-01 3 183698099 183698110 12 + 0.384 0.139 -1.909
ENSG00000163872 E004 1.0976782 0.1500237407 4.567404e-01 5.971208e-01 3 183698111 183698123 13 + 0.384 0.242 -0.932
ENSG00000163872 E005 2.7906952 0.0688181060 8.201361e-02 1.626969e-01 3 183698124 183698210 87 + 0.697 0.396 -1.419
ENSG00000163872 E006 35.2766600 0.0176868391 7.771825e-03 2.320596e-02 3 183715144 183715262 119 + 1.635 1.453 -0.625
ENSG00000163872 E007 38.4985778 0.0235745052 7.063673e-02 1.444009e-01 3 183717651 183717748 98 + 1.649 1.530 -0.408
ENSG00000163872 E008 38.3665373 0.0113091088 3.034420e-03 1.036759e-02 3 183718500 183718592 93 + 1.674 1.492 -0.619
ENSG00000163872 E009 68.7594893 0.0075581669 3.126248e-05 1.852312e-04 3 183721891 183722136 246 + 1.925 1.722 -0.685
ENSG00000163872 E010 50.4664529 0.0044343014 4.915307e-05 2.774620e-04 3 183724419 183724531 113 + 1.790 1.596 -0.660
ENSG00000163872 E011 62.2879200 0.0211957225 3.167446e-03 1.075993e-02 3 183728690 183728851 162 + 1.882 1.688 -0.653
ENSG00000163872 E012 58.6255322 0.0242414197 9.892760e-03 2.849990e-02 3 183736718 183736829 112 + 1.846 1.675 -0.581
ENSG00000163872 E013 34.4288137 0.0388857931 1.102065e-01 2.058496e-01 3 183747672 183747716 45 + 1.600 1.479 -0.413
ENSG00000163872 E014 78.1178118 0.0068554109 1.341197e-02 3.687373e-02 3 183752073 183752253 181 + 1.936 1.845 -0.305
ENSG00000163872 E015 12.3438315 0.0016063326 3.505813e-02 8.175958e-02 3 183754123 183754125 3 + 1.199 1.042 -0.564
ENSG00000163872 E016 98.1898599 0.0003838790 1.512524e-04 7.526372e-04 3 183754126 183754365 240 + 2.035 1.944 -0.305
ENSG00000163872 E017 68.9933461 0.0003665713 1.250783e-04 6.370158e-04 3 183756528 183756689 162 + 1.897 1.779 -0.397
ENSG00000163872 E018 48.1186124 0.0005647011 1.536081e-06 1.224927e-05 3 183758862 183758965 104 + 1.776 1.573 -0.689
ENSG00000163872 E019 54.7432290 0.0004321336 2.350984e-07 2.223266e-06 3 183761507 183761614 108 + 1.831 1.626 -0.693
ENSG00000163872 E020 79.4280228 0.0080268771 6.921020e-03 2.101932e-02 3 183762097 183762279 183 + 1.951 1.840 -0.374
ENSG00000163872 E021 105.3683575 0.0003329575 1.145451e-02 3.224492e-02 3 183772305 183772563 259 + 2.044 2.003 -0.139
ENSG00000163872 E022 70.5234665 0.0003628369 1.134141e-01 2.105023e-01 3 183773633 183773794 162 + 1.864 1.843 -0.069
ENSG00000163872 E023 23.0467471 0.0008726606 1.706643e-01 2.890203e-01 3 183775915 183775990 76 + 1.407 1.353 -0.186
ENSG00000163872 E024 56.1297337 0.0004565989 6.587724e-02 1.365065e-01 3 183775991 183776123 133 + 1.772 1.731 -0.139
ENSG00000163872 E025 96.6480258 0.0002973421 2.831423e-03 9.768107e-03 3 183777542 183777700 159 + 2.017 1.955 -0.206
ENSG00000163872 E026 104.7829090 0.0002797573 8.646956e-02 1.697589e-01 3 183786125 183786301 177 + 2.028 2.015 -0.044
ENSG00000163872 E027 97.9642789 0.0039279164 9.578417e-01 9.775711e-01 3 183790797 183790980 184 + 1.973 2.016 0.145
ENSG00000163872 E028 13.6846375 0.0013217920 7.261168e-02 1.476923e-01 3 183793116 183793486 371 + 1.052 1.258 0.737
ENSG00000163872 E029 52.3582415 0.0004834348 3.378320e-01 4.817205e-01 3 183797923 183797995 73 + 1.679 1.771 0.311
ENSG00000163872 E030 49.2686328 0.0004804012 2.584985e-01 3.957697e-01 3 183797996 183798051 56 + 1.647 1.748 0.345
ENSG00000163872 E031 55.6609838 0.0004398152 5.445935e-02 1.170595e-01 3 183798891 183798989 99 + 1.679 1.815 0.460
ENSG00000163872 E032 61.8821281 0.0004196817 2.931163e-02 7.060933e-02 3 183800466 183800568 103 + 1.719 1.862 0.484
ENSG00000163872 E033 0.8815316 0.0136968632 1.312994e-02 3.621025e-02 3 183800977 183801454 478 + 0.433 0.000 -16.376
ENSG00000163872 E034 46.2642583 0.0010181954 4.397248e-01 5.814757e-01 3 183801455 183801528 74 + 1.627 1.712 0.291
ENSG00000163872 E035 23.6904341 0.0201582997 2.103604e-01 3.389711e-01 3 183801529 183803255 1727 + 1.421 1.344 -0.270
ENSG00000163872 E036 50.1199383 0.0004728227 2.301045e-01 3.625918e-01 3 183803256 183803335 80 + 1.655 1.760 0.355
ENSG00000163872 E037 6.8372514 0.0092273886 8.045537e-01 8.756415e-01 3 183803336 183803986 651 + 0.894 0.905 0.042
ENSG00000163872 E038 109.9272932 0.0002660353 7.728907e-01 8.534282e-01 3 183803987 183804188 202 + 2.018 2.073 0.187
ENSG00000163872 E039 122.8232928 0.0015893937 2.448856e-01 3.799048e-01 3 183806866 183807092 227 + 2.050 2.138 0.297
ENSG00000163872 E040 0.3332198 0.0291079293 9.087018e-01   3 183808024 183808029 6 + 0.109 0.137 0.383
ENSG00000163872 E041 64.7894459 0.0004214854 4.456199e-05 2.541434e-04 3 183808030 183808104 75 + 1.697 1.922 0.759
ENSG00000163872 E042 1.3682388 0.0096449220 9.986599e-02 1.902758e-01 3 183808933 183809096 164 + 0.196 0.509 1.967
ENSG00000163872 E043 74.2022307 0.0003987730 1.504580e-06 1.202845e-05 3 183809097 183809170 74 + 1.744 1.988 0.822
ENSG00000163872 E044 4.1328962 0.0993030924 7.475203e-01 8.350017e-01 3 183809171 183809479 309 + 0.722 0.679 -0.179
ENSG00000163872 E045 685.6979957 0.0099820731 1.186699e-08 1.442982e-07 3 183810475 183812877 2403 + 2.680 2.959 0.927