ENSG00000163848

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360647 ENSG00000163848 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF148 protein_coding protein_coding 6.692408 1.044477 11.78986 0.1052756 0.09873899 3.484171 2.00489849 0.67747331 3.774094 0.08199532 0.08954238 2.460572 0.39151667 0.67066667 0.32013333 -0.35053333 0.13525322 0.01879209 FALSE  
ENST00000468369 ENSG00000163848 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF148 protein_coding protein_coding 6.692408 1.044477 11.78986 0.1052756 0.09873899 3.484171 0.05268418 0.11382250 0.000000 0.11382250 0.00000000 -3.630202 0.02459167 0.11423333 0.00000000 -0.11423333 0.36120544 0.01879209 FALSE  
ENST00000484491 ENSG00000163848 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF148 protein_coding protein_coding 6.692408 1.044477 11.78986 0.1052756 0.09873899 3.484171 0.75096998 0.00000000 1.602148 0.00000000 0.93200634 7.332840 0.08277083 0.00000000 0.13546667 0.13546667 0.52763998 0.01879209 FALSE  
ENST00000485866 ENSG00000163848 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF148 protein_coding protein_coding 6.692408 1.044477 11.78986 0.1052756 0.09873899 3.484171 0.82982100 0.05936701 1.475282 0.05936701 0.27338482 4.420344 0.11091250 0.04763333 0.12543333 0.07780000 0.36421824 0.01879209 FALSE  
ENST00000492394 ENSG00000163848 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF148 protein_coding protein_coding 6.692408 1.044477 11.78986 0.1052756 0.09873899 3.484171 2.31134774 0.14535567 3.433609 0.14535567 1.04078652 4.470275 0.30494583 0.11666667 0.29160000 0.17493333 0.34950022 0.01879209 FALSE  
MSTRG.23580.7 ENSG00000163848 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF148 protein_coding   6.692408 1.044477 11.78986 0.1052756 0.09873899 3.484171 0.41199757 0.00000000 1.117823 0.00000000 0.31116984 6.817397 0.04507500 0.00000000 0.09446667 0.09446667 0.01879209 0.01879209 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163848 E001 333.3293723 0.0188743703 1.331471e-05 8.594316e-05 3 125225669 125232058 6390 - 2.278 2.595 1.058
ENSG00000163848 E002 24.2543974 0.0110259130 9.205179e-01 9.538355e-01 3 125232059 125232075 17 - 1.211 1.277 0.234
ENSG00000163848 E003 22.9226878 0.0100545246 7.496174e-01 8.365183e-01 3 125232076 125232078 3 - 1.190 1.229 0.138
ENSG00000163848 E004 65.6370527 0.0004725356 7.143963e-02 1.457277e-01 3 125232079 125232327 249 - 1.605 1.793 0.637
ENSG00000163848 E005 23.1936586 0.0008733667 2.494922e-01 3.853096e-01 3 125232328 125232340 13 - 1.172 1.362 0.667
ENSG00000163848 E006 44.9354631 0.0004689011 8.645257e-02 1.697326e-01 3 125232341 125232451 111 - 1.442 1.644 0.690
ENSG00000163848 E007 34.7649899 0.0031742212 6.036649e-03 1.870686e-02 3 125232452 125232507 56 - 1.313 1.614 1.033
ENSG00000163848 E008 25.8351477 0.0080720402 1.795906e-02 4.704749e-02 3 125232508 125232511 4 - 1.187 1.494 1.067
ENSG00000163848 E009 57.3157338 0.0071342944 5.770262e-01 7.023684e-01 3 125232512 125232654 143 - 1.554 1.675 0.411
ENSG00000163848 E010 72.0136089 0.0004264137 1.946352e-01 3.195433e-01 3 125232655 125232865 211 - 1.666 1.663 -0.011
ENSG00000163848 E011 63.1456657 0.0006575627 3.554252e-01 4.997628e-01 3 125232866 125233108 243 - 1.607 1.624 0.057
ENSG00000163848 E012 142.8404927 0.0020182795 8.095345e-05 4.324983e-04 3 125233109 125233939 831 - 1.972 1.846 -0.424
ENSG00000163848 E013 32.5410712 0.0006672660 2.995131e-02 7.186243e-02 3 125234211 125234299 89 - 1.348 1.204 -0.503
ENSG00000163848 E014 20.5797631 0.0037281507 3.578077e-01 5.022159e-01 3 125234300 125234329 30 - 1.150 1.114 -0.127
ENSG00000163848 E015 29.6356988 0.0174036240 9.079439e-01 9.455676e-01 3 125277726 125277809 84 - 1.288 1.345 0.199
ENSG00000163848 E016 42.2835585 0.0089800539 2.448667e-02 6.082720e-02 3 125279124 125279247 124 - 1.455 1.304 -0.524
ENSG00000163848 E017 48.9517547 0.0004408611 4.283983e-05 2.452520e-04 3 125288103 125288228 126 - 1.529 1.231 -1.034
ENSG00000163848 E018 0.4482035 0.0278792305 1.000000e+00 1.000000e+00 3 125292465 125292793 329 - 0.120 0.000 -8.642
ENSG00000163848 E019 43.8010912 0.0005216061 1.011005e-02 2.903230e-02 3 125313308 125313390 83 - 1.472 1.323 -0.519
ENSG00000163848 E020 29.4153409 0.0043215072 7.740615e-03 2.312663e-02 3 125313391 125313414 24 - 1.313 1.080 -0.830
ENSG00000163848 E021 53.5618556 0.0039213312 3.783918e-04 1.691087e-03 3 125313415 125313563 149 - 1.566 1.322 -0.838
ENSG00000163848 E022 42.7358858 0.0005464334 4.842708e-06 3.459936e-05 3 125313564 125313652 89 - 1.479 1.080 -1.402
ENSG00000163848 E023 22.3047520 0.0016113663 1.510639e-03 5.670644e-03 3 125313653 125313656 4 - 1.208 0.845 -1.334
ENSG00000163848 E024 5.8325903 0.0028087201 8.793135e-01 9.264783e-01 3 125314937 125315053 117 - 0.663 0.699 0.155
ENSG00000163848 E025 30.7360141 0.0045858180 6.976920e-02 1.429884e-01 3 125323309 125323387 79 - 1.322 1.205 -0.414
ENSG00000163848 E026 26.2737144 0.0007400003 5.114040e-01 6.464471e-01 3 125323388 125323444 57 - 1.246 1.256 0.034
ENSG00000163848 E027 21.9706979 0.0008629015 3.128359e-02 7.445175e-02 3 125331158 125331233 76 - 1.193 1.000 -0.697
ENSG00000163848 E028 9.4381136 0.0047028941 1.721286e-02 4.541361e-02 3 125331234 125331238 5 - 0.878 0.477 -1.713
ENSG00000163848 E029 0.1515154 0.0434560988 7.075699e-01   3 125338822 125338911 90 - 0.044 0.000 -7.058
ENSG00000163848 E030 0.7437457 0.0153787590 5.578436e-01 6.861697e-01 3 125356977 125357280 304 - 0.153 0.301 1.240
ENSG00000163848 E031 0.0000000       3 125357736 125357818 83 -      
ENSG00000163848 E032 0.5202097 0.0206250977 2.748200e-01 4.140402e-01 3 125374227 125374280 54 - 0.083 0.302 2.243
ENSG00000163848 E033 14.6594600 0.0155507755 1.619412e-02 4.315129e-02 3 125375102 125375325 224 - 1.043 0.699 -1.329