ENSG00000163820

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296137 ENSG00000163820 HEK293_OSMI2_2hA HEK293_TMG_2hB FYCO1 protein_coding protein_coding 7.57906 7.664403 6.494823 0.2727284 0.17173 -0.2385447 4.80960767 4.06257398 4.7445289 0.53057255 0.31516316 0.2233615 0.64556667 0.526533333 0.72963333 0.20310000 0.044022575 0.007039216 FALSE TRUE
ENST00000433878 ENSG00000163820 HEK293_OSMI2_2hA HEK293_TMG_2hB FYCO1 protein_coding protein_coding 7.57906 7.664403 6.494823 0.2727284 0.17173 -0.2385447 1.79635622 2.96185988 0.4280615 0.21174062 0.25326211 -2.7621607 0.22172500 0.389333333 0.06460000 -0.32473333 0.072461847 0.007039216 TRUE TRUE
ENST00000691721 ENSG00000163820 HEK293_OSMI2_2hA HEK293_TMG_2hB FYCO1 protein_coding processed_transcript 7.57906 7.664403 6.494823 0.2727284 0.17173 -0.2385447 0.63154687 0.60794009 0.4939231 0.06529161 0.04406279 -0.2942634 0.08235000 0.080100000 0.07590000 -0.00420000 0.977170749 0.007039216 FALSE TRUE
MSTRG.22859.2 ENSG00000163820 HEK293_OSMI2_2hA HEK293_TMG_2hB FYCO1 protein_coding   7.57906 7.664403 6.494823 0.2727284 0.17173 -0.2385447 0.08946634 0.00000000 0.3406459 0.00000000 0.34064589 5.1319429 0.01379583 0.000000000 0.05453333 0.05453333 0.812850867 0.007039216 TRUE TRUE
MSTRG.22859.4 ENSG00000163820 HEK293_OSMI2_2hA HEK293_TMG_2hB FYCO1 protein_coding   7.57906 7.664403 6.494823 0.2727284 0.17173 -0.2385447 0.22376522 0.03202929 0.4876640 0.02010218 0.23377107 3.5657051 0.03252500 0.004033333 0.07536667 0.07133333 0.007039216 0.007039216 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163820 E001 1.2177675 0.0136685350 5.268977e-03 1.666319e-02 3 45917903 45917903 1 - 0.000 0.510 12.231
ENSG00000163820 E002 268.7285796 0.0065514599 2.009104e-14 6.320469e-13 3 45917904 45918817 914 - 2.207 2.547 1.134
ENSG00000163820 E003 107.1825510 0.0108001919 6.691546e-06 4.629659e-05 3 45918818 45919065 248 - 1.840 2.136 0.994
ENSG00000163820 E004 87.7433047 0.0003345273 8.292681e-10 1.247933e-08 3 45919066 45919412 347 - 1.778 2.040 0.880
ENSG00000163820 E005 368.8225954 0.0003801543 2.411501e-01 3.755367e-01 3 45919413 45921584 2172 - 2.540 2.584 0.149
ENSG00000163820 E006 63.8287211 0.0085018878 6.094150e-01 7.289271e-01 3 45921585 45921840 256 - 1.813 1.806 -0.026
ENSG00000163820 E007 43.4056275 0.0046227775 2.080782e-01 3.361701e-01 3 45923656 45923765 110 - 1.670 1.617 -0.180
ENSG00000163820 E008 23.7859604 0.0129609628 3.282592e-01 4.717501e-01 3 45925516 45926936 1421 - 1.327 1.435 0.372
ENSG00000163820 E009 69.2322523 0.0009176233 5.828441e-01 7.070919e-01 3 45931071 45931281 211 - 1.841 1.840 -0.004
ENSG00000163820 E010 51.9422811 0.0004714973 6.081985e-01 7.280051e-01 3 45936448 45936543 96 - 1.719 1.717 -0.007
ENSG00000163820 E011 0.0000000       3 45939327 45939403 77 -      
ENSG00000163820 E012 55.2748666 0.0004785657 9.039448e-01 9.428800e-01 3 45955249 45955393 145 - 1.738 1.755 0.058
ENSG00000163820 E013 59.0354876 0.0003936333 5.335317e-01 6.657146e-01 3 45958408 45958619 212 - 1.746 1.797 0.173
ENSG00000163820 E014 0.2214452 0.0402027931 5.250605e-01   3 45958620 45958661 42 - 0.000 0.121 11.461
ENSG00000163820 E015 54.9531289 0.0004392268 3.237132e-01 4.670431e-01 3 45959393 45959542 150 - 1.759 1.735 -0.079
ENSG00000163820 E016 57.7317363 0.0004639968 1.353878e-02 3.717003e-02 3 45962225 45962392 168 - 1.815 1.725 -0.305
ENSG00000163820 E017 35.9240894 0.0008918771 5.055459e-01 6.413148e-01 3 45964336 45964454 119 - 1.578 1.562 -0.055
ENSG00000163820 E018 25.7339676 0.0008338414 2.661962e-01 4.043625e-01 3 45965033 45965125 93 - 1.455 1.403 -0.181
ENSG00000163820 E019 297.9208152 0.0024771804 4.354448e-09 5.734305e-08 3 45966277 45968703 2427 - 2.544 2.404 -0.465
ENSG00000163820 E020 27.8318783 0.0020397165 1.115118e-03 4.354079e-03 3 45969675 45969765 91 - 1.550 1.351 -0.686
ENSG00000163820 E021 36.8364910 0.0013357292 5.369049e-05 3.001771e-04 3 45973088 45973231 144 - 1.679 1.464 -0.733
ENSG00000163820 E022 30.5462276 0.0013077723 1.321476e-05 8.535034e-05 3 45975239 45975345 107 - 1.614 1.357 -0.884
ENSG00000163820 E023 31.9291074 0.0050183990 1.058714e-02 3.017967e-02 3 45979705 45979830 126 - 1.589 1.436 -0.523
ENSG00000163820 E024 30.5296062 0.0280740007 4.477457e-03 1.447807e-02 3 45981570 45981676 107 - 1.617 1.369 -0.854
ENSG00000163820 E025 0.0000000       3 45984581 45984855 275 -      
ENSG00000163820 E026 39.6947991 0.0009719582 9.470799e-11 1.677463e-09 3 45984856 45985022 167 - 1.764 1.419 -1.176
ENSG00000163820 E027 4.2477964 0.1072018925 8.584229e-03 2.524890e-02 3 45985152 45985235 84 - 0.936 0.413 -2.267
ENSG00000163820 E028 19.3992131 0.0019136402 2.007724e-09 2.809137e-08 3 45995722 45995881 160 - 1.503 1.038 -1.638