ENSG00000163812

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296127 ENSG00000163812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC3 protein_coding protein_coding 62.62488 81.93564 46.66595 6.982375 0.9230028 -0.8119879 24.994284 33.002696 19.180884 2.9004372 0.5090120 -0.7825998 0.4000458 0.40516667 0.41173333 0.006566667 0.97350371 6.404174e-08 FALSE  
ENST00000339420 ENSG00000163812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC3 protein_coding protein_coding 62.62488 81.93564 46.66595 6.982375 0.9230028 -0.8119879 6.675330 10.040877 4.480793 0.1777884 0.2071653 -1.1622793 0.1040542 0.12400000 0.09593333 -0.028066667 0.15840898 6.404174e-08 FALSE  
ENST00000433512 ENSG00000163812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC3 protein_coding protein_coding 62.62488 81.93564 46.66595 6.982375 0.9230028 -0.8119879 8.069809 11.780721 3.229660 4.1828302 1.9043816 -1.8637377 0.1244125 0.13693333 0.06766667 -0.069266667 0.69960138 6.404174e-08    
MSTRG.22847.6 ENSG00000163812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC3 protein_coding   62.62488 81.93564 46.66595 6.982375 0.9230028 -0.8119879 5.995197 4.999436 7.101112 1.9102504 0.5758694 0.5054271 0.1021875 0.05906667 0.15253333 0.093466667 0.02744485 6.404174e-08 TRUE  
MSTRG.22847.9 ENSG00000163812 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC3 protein_coding   62.62488 81.93564 46.66595 6.982375 0.9230028 -0.8119879 12.514470 18.201095 8.692911 1.4140212 0.8097138 -1.0652478 0.1970792 0.22700000 0.18710000 -0.039900000 0.70160989 6.404174e-08 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163812 E001 0.2214452 0.0445991673 8.124290e-01   3 44915257 44915260 4 - 0.000 0.096 9.519
ENSG00000163812 E002 658.7793010 0.0022577205 4.900194e-05 2.767243e-04 3 44915261 44917408 2148 - 2.709 2.825 0.387
ENSG00000163812 E003 135.3761593 0.0011335179 5.711914e-03 1.784945e-02 3 44917409 44917838 430 - 2.162 2.078 -0.280
ENSG00000163812 E004 115.0044348 0.0040622069 7.916876e-04 3.229605e-03 3 44917839 44918143 305 - 2.127 1.989 -0.463
ENSG00000163812 E005 36.1041533 0.0073074232 7.899903e-02 1.579122e-01 3 44918144 44918792 649 - 1.614 1.499 -0.395
ENSG00000163812 E006 89.1049081 0.0066559780 8.272954e-04 3.357008e-03 3 44918793 44919977 1185 - 2.035 1.862 -0.583
ENSG00000163812 E007 52.7788914 0.0004995584 4.494818e-08 4.892725e-07 3 44919978 44920337 360 - 1.857 1.604 -0.858
ENSG00000163812 E008 329.8685495 0.0004225262 5.526165e-57 4.985312e-54 3 44920338 44924845 4508 - 2.683 2.359 -1.081
ENSG00000163812 E009 1108.0448338 0.0063803411 3.592231e-01 5.035497e-01 3 44924846 44926080 1235 - 2.985 3.032 0.155
ENSG00000163812 E010 633.3863282 0.0001148071 5.460367e-02 1.173012e-01 3 44926081 44926522 442 - 2.786 2.771 -0.051
ENSG00000163812 E011 299.4235813 0.0019629062 6.281633e-01 7.437716e-01 3 44926523 44926612 90 - 2.453 2.450 -0.009
ENSG00000163812 E012 645.0788795 0.0014786813 2.633567e-02 6.462043e-02 3 44926613 44926847 235 - 2.740 2.802 0.204
ENSG00000163812 E013 575.6004456 0.0011108229 2.152766e-03 7.698195e-03 3 44929306 44929436 131 - 2.679 2.757 0.260
ENSG00000163812 E014 55.7261979 0.0005153634 2.643073e-01 4.022739e-01 3 44932907 44932990 84 - 1.756 1.714 -0.141
ENSG00000163812 E015 311.4517212 0.0004716175 1.325242e-01 2.375872e-01 3 44933118 44933137 20 - 2.435 2.483 0.159
ENSG00000163812 E016 372.5215481 0.0001874374 3.307075e-03 1.116843e-02 3 44933138 44933187 50 - 2.495 2.567 0.240
ENSG00000163812 E017 268.7239716 0.0001630541 8.555275e-03 2.517742e-02 3 44933188 44933199 12 - 2.353 2.427 0.248
ENSG00000163812 E018 1.1039192 0.0341548515 7.114871e-01 8.084322e-01 3 44933200 44933449 250 - 0.358 0.298 -0.376
ENSG00000163812 E019 442.1574789 0.0002123739 1.474026e-02 3.990422e-02 3 44933888 44933984 97 - 2.579 2.638 0.194
ENSG00000163812 E020 524.3737234 0.0011935724 1.775916e-01 2.981109e-01 3 44945168 44945292 125 - 2.664 2.707 0.141
ENSG00000163812 E021 0.2965864 0.1552264850 4.520209e-01   3 44945293 44945329 37 - 0.000 0.172 10.491
ENSG00000163812 E022 2.9591966 0.3361617608 9.853788e-01 9.948946e-01 3 44958588 44958685 98 - 0.604 0.552 -0.233
ENSG00000163812 E023 10.9207639 0.0495003674 2.759366e-01 4.153387e-01 3 44959127 44959130 4 - 1.140 0.998 -0.517
ENSG00000163812 E024 772.4757228 0.0002311861 4.818133e-02 1.059574e-01 3 44959131 44959460 330 - 2.872 2.856 -0.052
ENSG00000163812 E025 1.3566106 0.0096765512 1.375103e-01 2.446210e-01 3 44961555 44961646 92 - 0.155 0.437 2.020
ENSG00000163812 E026 0.1515154 0.0432781491 2.819516e-01   3 44969609 44969931 323 - 0.155 0.000 -11.363
ENSG00000163812 E027 232.6360836 0.0092818406 1.033297e-01 1.955458e-01 3 44975933 44976185 253 - 2.387 2.314 -0.244