ENSG00000163755

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296051 ENSG00000163755 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS3 protein_coding protein_coding 6.439126 2.985533 9.202899 0.3281258 0.4076011 1.620843 4.4358106 1.7840120 6.8391019 0.05301843 0.01650769 1.9327253 0.68214583 0.61340000 0.74606667 0.132666667 0.359048323 0.001036551 FALSE TRUE
ENST00000460120 ENSG00000163755 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS3 protein_coding protein_coding 6.439126 2.985533 9.202899 0.3281258 0.4076011 1.620843 0.3515034 0.5287563 0.2747433 0.11530666 0.12284591 -0.9199709 0.06339167 0.17300000 0.02886667 -0.144133333 0.001036551 0.001036551 FALSE TRUE
ENST00000486530 ENSG00000163755 HEK293_OSMI2_2hA HEK293_TMG_2hB HPS3 protein_coding retained_intron 6.439126 2.985533 9.202899 0.3281258 0.4076011 1.620843 0.7356906 0.2738274 0.8880264 0.09281190 0.21978874 1.6617442 0.11062500 0.08763333 0.09470000 0.007066667 0.953991910 0.001036551 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163755 E001 0.7322062 0.2431492217 2.548614e-01 3.916477e-01 3 149129638 149129638 1 + 0.295 0.000 -9.769
ENSG00000163755 E002 15.2153458 0.0011706873 6.235905e-01 7.401394e-01 3 149129639 149129690 52 + 1.183 1.147 -0.128
ENSG00000163755 E003 38.3480398 0.0006869815 2.248564e-02 5.669503e-02 3 149129691 149129940 250 + 1.594 1.458 -0.465
ENSG00000163755 E004 1.2586448 0.0296696166 3.360926e-01 4.799148e-01 3 149129941 149130197 257 + 0.374 0.189 -1.328
ENSG00000163755 E005 3.2473283 0.0050132474 4.342588e-01 5.766426e-01 3 149130198 149130453 256 + 0.548 0.682 0.585
ENSG00000163755 E006 91.7139724 0.0002885380 6.758708e-06 4.671740e-05 3 149140004 149140498 495 + 1.979 1.802 -0.594
ENSG00000163755 E007 65.4832385 0.0012976657 2.199858e-02 5.567442e-02 3 149141017 149141188 172 + 1.819 1.716 -0.350
ENSG00000163755 E008 45.7905101 0.0005561181 5.007758e-01 6.369925e-01 3 149141295 149141380 86 + 1.646 1.620 -0.089
ENSG00000163755 E009 56.6367925 0.0005410605 7.353386e-01 8.261244e-01 3 149145354 149145546 193 + 1.726 1.721 -0.019
ENSG00000163755 E010 39.3214327 0.0025995231 3.424608e-01 4.864568e-01 3 149150599 149150680 82 + 1.585 1.533 -0.177
ENSG00000163755 E011 52.4736964 0.0031201157 4.176029e-01 5.609343e-01 3 149153494 149153648 155 + 1.702 1.664 -0.130
ENSG00000163755 E012 8.6495396 0.0019934273 7.338963e-04 3.021306e-03 3 149153649 149154135 487 + 0.797 1.179 1.422
ENSG00000163755 E013 36.5506501 0.0036307337 3.939407e-01 5.378492e-01 3 149155107 149155215 109 + 1.553 1.504 -0.167
ENSG00000163755 E014 45.8778381 0.0070914623 2.429587e-01 3.776609e-01 3 149157350 149157531 182 + 1.607 1.693 0.292
ENSG00000163755 E015 56.4892958 0.0046735080 9.997555e-01 1.000000e+00 3 149158666 149158846 181 + 1.719 1.726 0.026
ENSG00000163755 E016 73.4036080 0.0003560022 5.216750e-02 1.130193e-01 3 149160046 149160279 234 + 1.856 1.779 -0.259
ENSG00000163755 E017 63.0696151 0.0003827202 2.161761e-02 5.488256e-02 3 149162148 149162333 186 + 1.800 1.698 -0.344
ENSG00000163755 E018 70.6752893 0.0004218256 1.636393e-01 2.798729e-01 3 149162690 149162878 189 + 1.836 1.783 -0.177
ENSG00000163755 E019 50.1737012 0.0004390841 1.676962e-01 2.851972e-01 3 149163842 149163949 108 + 1.646 1.730 0.282
ENSG00000163755 E020 29.1802332 0.0006686948 5.044670e-02 1.099641e-01 3 149167034 149167064 31 + 1.398 1.540 0.488
ENSG00000163755 E021 58.1112493 0.0004242312 9.728449e-02 1.863374e-01 3 149167065 149167214 150 + 1.707 1.799 0.310
ENSG00000163755 E022 37.8759869 0.0006513949 3.988013e-01 5.425383e-01 3 149167215 149167240 26 + 1.567 1.526 -0.140
ENSG00000163755 E023 3.8231139 0.0111448193 9.213221e-01 9.543279e-01 3 149167889 149167892 4 + 0.654 0.680 0.110
ENSG00000163755 E024 52.7702771 0.0004309837 6.627381e-01 7.709778e-01 3 149167893 149167983 91 + 1.687 1.721 0.116
ENSG00000163755 E025 1.6283978 0.0085112270 4.957206e-01 6.324736e-01 3 149167984 149168467 484 + 0.440 0.319 -0.694
ENSG00000163755 E026 2.3710994 0.0059409798 1.618209e-01 2.775071e-01 3 149170471 149170573 103 + 0.572 0.319 -1.332
ENSG00000163755 E027 143.1329545 0.0033930675 2.856537e-10 4.665997e-09 3 149172095 149173732 1638 + 2.034 2.286 0.842