ENSG00000163738

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000461101 ENSG00000163738 HEK293_OSMI2_2hA HEK293_TMG_2hB MTHFD2L protein_coding processed_transcript 8.018207 7.438168 11.06715 0.7963872 0.3751606 0.5726289 4.5431997 5.4839390 4.959781 1.00074422 0.1269548 -0.1446585 0.60757500 0.72630000 0.4498333 -0.2764667 0.004522479 0.0002517692   FALSE
ENST00000484725 ENSG00000163738 HEK293_OSMI2_2hA HEK293_TMG_2hB MTHFD2L protein_coding processed_transcript 8.018207 7.438168 11.06715 0.7963872 0.3751606 0.5726289 1.3906927 1.1883065 2.383655 0.09725255 0.4002094 0.9982184 0.16964167 0.16570000 0.2135000 0.0478000 0.633738125 0.0002517692   FALSE
MSTRG.25035.9 ENSG00000163738 HEK293_OSMI2_2hA HEK293_TMG_2hB MTHFD2L protein_coding   8.018207 7.438168 11.06715 0.7963872 0.3751606 0.5726289 0.6605752 0.1808193 1.534150 0.18081926 0.1299395 3.0165344 0.06505417 0.02706667 0.1390333 0.1119667 0.108588311 0.0002517692 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163738 E001 0.0000000       4 74114174 74114383 210 +      
ENSG00000163738 E002 0.0000000       4 74114488 74114657 170 +      
ENSG00000163738 E003 0.0000000       4 74123273 74123338 66 +      
ENSG00000163738 E004 0.0000000       4 74123339 74123343 5 +      
ENSG00000163738 E005 0.0000000       4 74123344 74123423 80 +      
ENSG00000163738 E006 0.0000000       4 74125438 74125439 2 +      
ENSG00000163738 E007 0.0000000       4 74125440 74125517 78 +      
ENSG00000163738 E008 0.0000000       4 74143393 74143467 75 +      
ENSG00000163738 E009 4.0111333 0.048203130 2.311823e-01 3.638786e-01 4 74158108 74158111 4 + 0.774 0.612 -0.674
ENSG00000163738 E010 4.1928377 0.013631171 2.672370e-01 4.055306e-01 4 74158112 74158113 2 + 0.773 0.647 -0.521
ENSG00000163738 E011 6.0792098 0.032011661 6.940635e-01 7.949761e-01 4 74158114 74158117 4 + 0.855 0.836 -0.076
ENSG00000163738 E012 82.2863108 0.005185445 3.592725e-04 1.616010e-03 4 74158118 74158174 57 + 1.799 2.010 0.709
ENSG00000163738 E013 124.6223753 0.002228291 3.048983e-06 2.277594e-05 4 74158175 74158281 107 + 1.983 2.186 0.681
ENSG00000163738 E014 92.9659170 0.003027168 7.564654e-06 5.165817e-05 4 74160055 74160088 34 + 1.841 2.068 0.762
ENSG00000163738 E015 249.1174304 0.015629457 3.243509e-02 7.669408e-02 4 74160089 74161779 1691 + 2.318 2.464 0.488
ENSG00000163738 E016 60.5515108 0.002576491 3.386302e-05 1.987868e-04 4 74161780 74162253 474 + 1.868 1.713 -0.522
ENSG00000163738 E017 15.3158134 0.001227448 1.040200e-11 2.159591e-10 4 74174506 74174690 185 + 1.424 0.835 -2.130
ENSG00000163738 E018 12.5441123 0.001479854 3.202758e-16 1.294268e-14 4 74175281 74175403 123 + 1.393 0.532 -3.302
ENSG00000163738 E019 1.8790870 0.042436828 4.263703e-01 5.692090e-01 4 74180687 74180866 180 + 0.499 0.378 -0.636
ENSG00000163738 E020 1.7779215 0.394062706 5.747131e-01 7.004843e-01 4 74181686 74181791 106 + 0.455 0.396 -0.317
ENSG00000163738 E021 1.9961721 0.063403130 6.601181e-01 7.688222e-01 4 74182727 74183931 1205 + 0.499 0.436 -0.319
ENSG00000163738 E022 0.2966881 0.027017020 2.076339e-01   4 74194040 74195738 1699 + 0.208 0.000 -11.630
ENSG00000163738 E023 0.5848434 0.024511049 3.955444e-02 9.020670e-02 4 74195739 74195838 100 + 0.349 0.000 -12.583
ENSG00000163738 E024 13.8222457 0.001224345 7.101543e-12 1.515052e-10 4 74199794 74199946 153 + 1.393 0.764 -2.302
ENSG00000163738 E025 10.4389138 0.001723115 1.638260e-09 2.334087e-08 4 74201263 74201370 108 + 1.276 0.647 -2.378
ENSG00000163738 E026 0.0000000       4 74224068 74224147 80 +      
ENSG00000163738 E027 8.3320363 0.002335515 5.361795e-08 5.741442e-07 4 74225302 74225394 93 + 1.190 0.574 -2.397
ENSG00000163738 E028 2.4807951 0.006340607 1.364218e-01 2.430704e-01 4 74241419 74241520 102 + 0.642 0.434 -0.980
ENSG00000163738 E029 5.7363164 0.040667680 3.769357e-02 8.675657e-02 4 74241567 74242210 644 + 0.955 0.677 -1.093
ENSG00000163738 E030 0.0000000       4 74280241 74280443 203 +      
ENSG00000163738 E031 7.8568660 0.002268137 5.998128e-09 7.722764e-08 4 74281425 74281550 126 + 1.181 0.486 -2.781
ENSG00000163738 E032 0.1515154 0.043597031 5.029901e-01   4 74288301 74288465 165 + 0.117 0.000 -10.607
ENSG00000163738 E033 0.1472490 0.044371730 5.027932e-01   4 74291659 74291707 49 + 0.117 0.000 -10.604
ENSG00000163738 E034 1.4811368 0.011135103 4.490439e-04 1.963260e-03 4 74293489 74293675 187 + 0.611 0.000 -13.818
ENSG00000163738 E035 23.9368144 0.041559573 3.462484e-05 2.026999e-04 4 74301697 74303099 1403 + 1.573 1.110 -1.613