ENSG00000163710

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295992 ENSG00000163710 HEK293_OSMI2_2hA HEK293_TMG_2hB PCOLCE2 protein_coding protein_coding 13.76306 13.44029 15.72238 2.131173 0.3591026 0.2260991 4.7728398 4.1736164 5.171274 0.25370433 0.6717389 0.3085563 0.37308750 0.32320000 0.3310333 0.007833333 0.98877698 0.01378861 FALSE TRUE
ENST00000470795 ENSG00000163710 HEK293_OSMI2_2hA HEK293_TMG_2hB PCOLCE2 protein_coding retained_intron 13.76306 13.44029 15.72238 2.131173 0.3591026 0.2260991 4.6517530 5.6495451 4.201040 1.24631835 0.2989980 -0.4265096 0.33336667 0.41353333 0.2673333 -0.146200000 0.01378861 0.01378861 FALSE FALSE
ENST00000483986 ENSG00000163710 HEK293_OSMI2_2hA HEK293_TMG_2hB PCOLCE2 protein_coding retained_intron 13.76306 13.44029 15.72238 2.131173 0.3591026 0.2260991 2.9904283 2.9095078 3.603188 0.89892897 0.2902444 0.3075473 0.19942500 0.20696667 0.2286000 0.021633333 0.85900992 0.01378861 FALSE FALSE
ENST00000495732 ENSG00000163710 HEK293_OSMI2_2hA HEK293_TMG_2hB PCOLCE2 protein_coding processed_transcript 13.76306 13.44029 15.72238 2.131173 0.3591026 0.2260991 0.8351285 0.4371797 1.693449 0.09361258 0.3722169 1.9295321 0.05878333 0.03583333 0.1070000 0.071166667 0.04476917 0.01378861 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163710 E001 0.0000000       3 142815922 142815947 26 -      
ENSG00000163710 E002 0.4427912 0.1620808733 5.995537e-01 7.209189e-01 3 142815948 142816001 54 - 0.217 0.122 -1.002
ENSG00000163710 E003 0.7352129 0.0951929864 1.975196e-01 3.231093e-01 3 142816535 142816612 78 - 0.361 0.122 -1.996
ENSG00000163710 E004 4.5328621 0.0035958538 4.614068e-01 6.013783e-01 3 142817874 142817914 41 - 0.689 0.794 0.425
ENSG00000163710 E005 6.2259016 0.0028713702 2.023652e-01 3.291788e-01 3 142817915 142817925 11 - 0.768 0.930 0.627
ENSG00000163710 E006 66.5246485 0.0075328426 2.492869e-03 8.743411e-03 3 142817926 142818187 262 - 1.729 1.907 0.602
ENSG00000163710 E007 54.5480121 0.0052332149 2.175016e-03 7.765009e-03 3 142818188 142818258 71 - 1.645 1.821 0.595
ENSG00000163710 E008 100.8037698 0.0003842218 1.646354e-02 4.375717e-02 3 142818259 142818465 207 - 1.966 2.051 0.287
ENSG00000163710 E009 85.8578198 0.0003932594 7.982950e-01 8.712623e-01 3 142820878 142820966 89 - 1.946 1.940 -0.017
ENSG00000163710 E010 94.2857958 0.0003636498 1.213653e-01 2.218754e-01 3 142820967 142821045 79 - 1.949 2.007 0.195
ENSG00000163710 E011 0.1472490 0.0431316438 5.009722e-01   3 142821046 142821100 55 - 0.122 0.000 -9.086
ENSG00000163710 E012 77.8426691 0.0003991557 2.936658e-01 4.347229e-01 3 142823532 142823615 84 - 1.875 1.919 0.149
ENSG00000163710 E013 0.3729606 0.0263496418 1.000000e+00 1.000000e+00 3 142829677 142829691 15 - 0.122 0.123 0.013
ENSG00000163710 E014 89.2615579 0.0003770277 3.071680e-01 4.493560e-01 3 142829692 142829846 155 - 1.936 1.976 0.136
ENSG00000163710 E015 0.1472490 0.0431316438 5.009722e-01   3 142829847 142829855 9 - 0.122 0.000 -9.086
ENSG00000163710 E016 73.4430103 0.0005442239 3.499575e-01 4.941447e-01 3 142838770 142838906 137 - 1.851 1.892 0.138
ENSG00000163710 E017 74.8088888 0.0004135868 3.220503e-02 7.624623e-02 3 142842924 142843048 125 - 1.928 1.848 -0.267
ENSG00000163710 E018 1.5469139 0.0084591079 7.418743e-03 2.230745e-02 3 142843245 142843309 65 - 0.593 0.123 -3.158
ENSG00000163710 E019 6.7589803 0.0024474937 3.594114e-03 1.199348e-02 3 142846652 142846742 91 - 1.043 0.692 -1.358
ENSG00000163710 E020 104.7172480 0.0020460251 3.396180e-04 1.538927e-03 3 142848217 142848472 256 - 2.094 1.961 -0.447
ENSG00000163710 E021 1.6220525 0.0103643037 9.958588e-01 1.000000e+00 3 142863889 142864109 221 - 0.418 0.420 0.011
ENSG00000163710 E022 3.4352726 0.0052654496 5.252473e-01 6.586434e-01 3 142864110 142864479 370 - 0.593 0.692 0.425
ENSG00000163710 E023 1.9081431 0.1950320524 7.762703e-01 8.559425e-01 3 142887226 142887668 443 - 0.418 0.479 0.314
ENSG00000163710 E024 58.6267954 0.0004882310 1.190748e-04 6.096693e-04 3 142887669 142887777 109 - 1.859 1.690 -0.571
ENSG00000163710 E025 0.6621732 0.1181139046 9.903817e-01 9.981159e-01 3 142888659 142888813 155 - 0.217 0.219 0.014
ENSG00000163710 E026 40.1644012 0.0005934406 1.334686e-05 8.612428e-05 3 142888814 142889206 393 - 1.729 1.496 -0.791