ENSG00000163697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295974 ENSG00000163697 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB2 protein_coding protein_coding 2.972112 2.151607 3.148573 0.104367 0.3531501 0.5471689 0.3071158 0.24693936 0.3255752 0.14053224 0.3255752 0.38520816 0.1046000 0.11633333 0.08446667 -0.031866667 6.706644e-01 8.432326e-08 FALSE TRUE
ENST00000502841 ENSG00000163697 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB2 protein_coding protein_coding 2.972112 2.151607 3.148573 0.104367 0.3531501 0.5471689 0.9038607 0.36341435 0.9576330 0.18183678 0.2224636 1.37368259 0.3007542 0.17340000 0.29670000 0.123300000 6.411014e-01 8.432326e-08 FALSE TRUE
ENST00000508593 ENSG00000163697 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB2 protein_coding protein_coding 2.972112 2.151607 3.148573 0.104367 0.3531501 0.5471689 0.3164144 0.12324335 0.6417209 0.12324335 0.3215050 2.29019079 0.1100708 0.05403333 0.22960000 0.175566667 5.940111e-01 8.432326e-08 FALSE TRUE
ENST00000513611 ENSG00000163697 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB2 protein_coding protein_coding 2.972112 2.151607 3.148573 0.104367 0.3531501 0.5471689 0.3194984 0.35386574 0.2575898 0.21457568 0.1515701 -0.44338302 0.1094667 0.15763333 0.08426667 -0.073366667 8.604569e-01 8.432326e-08 FALSE TRUE
ENST00000543538 ENSG00000163697 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB2 protein_coding protein_coding 2.972112 2.151607 3.148573 0.104367 0.3531501 0.5471689 0.2599144 0.48659470 0.0000000 0.13007427 0.0000000 -5.63399697 0.0943500 0.22530000 0.00000000 -0.225300000 8.432326e-08 8.432326e-08 FALSE TRUE
MSTRG.24778.9 ENSG00000163697 HEK293_OSMI2_2hA HEK293_TMG_2hB APBB2 protein_coding   2.972112 2.151607 3.148573 0.104367 0.3531501 0.5471689 0.2503183 0.07558753 0.0779786 0.07558753 0.0779786 0.03975197 0.0732500 0.03313333 0.02800000 -0.005133333 9.442999e-01 8.432326e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163697 E001 0.0000000       4 40810027 40810027 1 -      
ENSG00000163697 E002 116.7363746 0.007068964 0.0007373436 0.0030335201 4 40810028 40814606 4579 - 1.990 2.150 0.536
ENSG00000163697 E003 26.4261157 0.001117423 0.0191467393 0.0496583246 4 40814607 40815312 706 - 1.505 1.361 -0.496
ENSG00000163697 E004 4.3043353 0.029989768 0.1593445064 0.2742408764 4 40815313 40815332 20 - 0.813 0.595 -0.902
ENSG00000163697 E005 22.0298692 0.001020508 0.1069268509 0.2010027468 4 40815333 40815616 284 - 1.303 1.431 0.443
ENSG00000163697 E006 20.1484576 0.001010904 0.0001804664 0.0008799984 4 40815617 40815745 129 - 1.164 1.459 1.031
ENSG00000163697 E007 21.0500248 0.005807988 0.0139031115 0.0380083518 4 40815746 40815903 158 - 1.236 1.446 0.733
ENSG00000163697 E008 14.9631723 0.001298601 0.7184697121 0.8135556710 4 40815904 40815972 69 - 1.189 1.233 0.153
ENSG00000163697 E009 18.3397577 0.001075217 0.2192046350 0.3494153126 4 40815973 40816084 112 - 1.333 1.251 -0.288
ENSG00000163697 E010 21.5402630 0.001106872 0.1202391923 0.2203313272 4 40816085 40816259 175 - 1.408 1.309 -0.344
ENSG00000163697 E011 14.3595834 0.001193312 0.0955161271 0.1836601596 4 40821871 40821982 112 - 1.250 1.116 -0.475
ENSG00000163697 E012 10.9919608 0.001579853 0.1903085302 0.3141680888 4 40821983 40822029 47 - 1.138 1.022 -0.421
ENSG00000163697 E013 8.6141706 0.006279055 0.1699450352 0.2881425562 4 40822030 40822050 21 - 1.047 0.901 -0.543
ENSG00000163697 E014 0.2924217 0.027474568 0.2686175780   4 40822051 40822466 416 - 0.198 0.000 -11.500
ENSG00000163697 E015 9.2431335 0.050144584 0.3275518488 0.4710209659 4 40823644 40823665 22 - 1.069 0.925 -0.534
ENSG00000163697 E016 8.3166512 0.059074642 0.5111260076 0.6462269257 4 40823666 40823667 2 - 1.012 0.906 -0.397
ENSG00000163697 E017 14.5123650 0.010366375 0.9046915364 0.9433108822 4 40823668 40823759 92 - 1.190 1.185 -0.017
ENSG00000163697 E018 13.5565740 0.004811629 0.5150820593 0.6497932430 4 40825887 40825967 81 - 1.181 1.129 -0.186
ENSG00000163697 E019 6.8103704 0.047433592 0.8153772592 0.8830988950 4 40825968 40825970 3 - 0.901 0.863 -0.142
ENSG00000163697 E020 0.3332198 0.029653846 0.8816803697   4 40826786 40827131 346 - 0.110 0.135 0.339
ENSG00000163697 E021 12.7899125 0.027343295 0.8100078801 0.8794149799 4 40827132 40827219 88 - 1.147 1.119 -0.099
ENSG00000163697 E022 0.0000000       4 40830458 40830462 5 -      
ENSG00000163697 E023 9.5516686 0.002487696 0.7949306027 0.8690273056 4 40830463 40830577 115 - 0.999 1.037 0.140
ENSG00000163697 E024 0.0000000       4 40830578 40830583 6 -      
ENSG00000163697 E025 0.0000000       4 40842370 40842375 6 -      
ENSG00000163697 E026 0.0000000       4 40842376 40842516 141 -      
ENSG00000163697 E027 2.2539230 0.015744959 0.8849487849 0.9304609509 4 40856985 40857025 41 - 0.520 0.504 -0.077
ENSG00000163697 E028 3.3202794 0.005591558 0.5340640893 0.6661805652 4 40857026 40857192 167 - 0.678 0.594 -0.362
ENSG00000163697 E029 0.0000000       4 40890309 40890363 55 -      
ENSG00000163697 E030 6.6502506 0.002566199 0.2323665095 0.3652479018 4 40890364 40890491 128 - 0.945 0.812 -0.509
ENSG00000163697 E031 0.0000000       4 40890849 40890914 66 -      
ENSG00000163697 E032 0.1482932 0.040761132 0.3994782811   4 40892395 40893264 870 - 0.000 0.135 10.739
ENSG00000163697 E033 8.6442709 0.034039700 0.6324346205 0.7472936371 4 40893265 40893362 98 - 1.012 0.956 -0.206
ENSG00000163697 E034 6.0242660 0.029933534 0.4940698772 0.6310725937 4 40893363 40893411 49 - 0.793 0.900 0.417
ENSG00000163697 E035 8.0288571 0.022279937 0.5978791371 0.7195766953 4 40934456 40934516 61 - 0.916 0.991 0.282
ENSG00000163697 E036 8.7652014 0.016355479 0.7274630738 0.8201655436 4 40934614 40934699 86 - 0.959 1.008 0.182
ENSG00000163697 E037 0.2934659 0.028861397 0.8871555911   4 40934700 40935076 377 - 0.110 0.135 0.337
ENSG00000163697 E038 3.9688487 0.011257443 0.9285532679 0.9590332393 4 40935077 40935139 63 - 0.703 0.701 -0.010
ENSG00000163697 E039 1.2932139 0.067859869 0.2979986811 0.4393860509 4 40935140 40935626 487 - 0.437 0.240 -1.238
ENSG00000163697 E040 11.4837757 0.004950079 0.6814202726 0.7851179953 4 40944865 40945070 206 - 1.109 1.079 -0.111
ENSG00000163697 E041 1.4976081 0.135548531 0.1789875465 0.2998695920 4 40945071 40945073 3 - 0.519 0.237 -1.664
ENSG00000163697 E042 16.5078587 0.055767196 0.4892319659 0.6266879450 4 41013583 41013946 364 - 1.289 1.204 -0.299
ENSG00000163697 E043 15.5827858 0.025757414 0.5950519509 0.7172037775 4 41013947 41014212 266 - 1.250 1.200 -0.176
ENSG00000163697 E044 8.7419604 0.024740582 0.7209475618 0.8154743516 4 41014213 41014287 75 - 1.011 0.972 -0.144
ENSG00000163697 E045 6.1278378 0.003187830 0.2598006643 0.3972594249 4 41014288 41014335 48 - 0.916 0.787 -0.498
ENSG00000163697 E046 5.4121280 0.003072443 0.3571815084 0.5015785960 4 41014336 41014387 52 - 0.750 0.880 0.508
ENSG00000163697 E047 4.2413970 0.004149500 0.0388735660 0.0889483720 4 41014388 41014398 11 - 0.557 0.858 1.255
ENSG00000163697 E048 6.0043689 0.002917476 0.0803871556 0.1601647540 4 41033236 41033289 54 - 0.728 0.956 0.890
ENSG00000163697 E049 4.8014638 0.003379164 0.5829385545 0.7071431520 4 41033290 41033304 15 - 0.728 0.812 0.338
ENSG00000163697 E050 2.6518903 0.005881952 0.4259186527 0.5687892444 4 41065576 41065589 14 - 0.621 0.504 -0.536
ENSG00000163697 E051 2.3896470 0.012537425 0.1066177492 0.2005630299 4 41065590 41065604 15 - 0.650 0.391 -1.249
ENSG00000163697 E052 1.7922199 0.139252712 0.1056364782 0.1990680874 4 41065605 41065668 64 - 0.589 0.237 -1.986
ENSG00000163697 E053 0.9139106 0.271086210 0.2787718358 0.4184362791 4 41065669 41065673 5 - 0.388 0.136 -1.974
ENSG00000163697 E054 6.3356817 0.002797273 0.0873090586 0.1710560853 4 41100639 41100750 112 - 0.959 0.760 -0.769
ENSG00000163697 E055 0.5901540 0.022193893 0.4191942387 0.5624417724 4 41118089 41118205 117 - 0.271 0.135 -1.248
ENSG00000163697 E056 0.0000000       4 41138042 41138156 115 -      
ENSG00000163697 E057 8.7896104 0.002000288 0.0056803067 0.0177678454 4 41142987 41143142 156 - 1.109 0.812 -1.112
ENSG00000163697 E058 0.3289534 0.029308278 0.8818712355   4 41177559 41177629 71 - 0.110 0.135 0.339
ENSG00000163697 E059 0.4804688 0.021025185 0.6992793437 0.7990757649 4 41177630 41177690 61 - 0.198 0.135 -0.661
ENSG00000163697 E060 0.3268771 0.029679825 0.8823917675   4 41193793 41194145 353 - 0.110 0.135 0.340
ENSG00000163697 E061 0.0000000       4 41207837 41207908 72 -      
ENSG00000163697 E062 5.6269736 0.003105846 0.0147032320 0.0398217278 4 41214405 41214618 214 - 0.945 0.633 -1.246
ENSG00000163697 E063 0.4439371 0.021579511 0.1234011950 0.2247991364 4 41216506 41216714 209 - 0.271 0.000 -12.076