ENSG00000163681

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000416658 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding protein_coding 15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 0.1621472 0.65844786 0.1001132 0.65844786 0.10011322 -2.60182736 0.03205417 0.16263333 0.004533333 -0.158100000 8.526855e-01 3.9428e-09 FALSE TRUE
ENST00000449503 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding protein_coding 15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 0.7063249 0.67424959 0.6690002 0.33982998 0.35549338 -0.01111065 0.05524167 0.09550000 0.029433333 -0.066066667 7.935321e-01 3.9428e-09 FALSE TRUE
ENST00000460223 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding protein_coding 15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 0.3293547 0.54577617 0.0000000 0.54577617 0.00000000 -5.79643206 0.04105000 0.07236667 0.000000000 -0.072366667 5.813169e-01 3.9428e-09   FALSE
ENST00000494088 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding protein_coding 15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 3.2961582 1.36467269 5.7685949 0.70722624 0.93406959 2.07163059 0.20097500 0.19636667 0.236533333 0.040166667 8.329154e-01 3.9428e-09 FALSE TRUE
ENST00000497084 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding retained_intron 15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 0.6877936 0.23555291 0.6428166 0.10122089 0.09791712 1.41064391 0.05211250 0.03640000 0.026866667 -0.009533333 7.738351e-01 3.9428e-09 FALSE FALSE
ENST00000671191 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding protein_coding 15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 1.3050621 0.62235026 2.8873429 0.13422496 0.08192247 2.19593466 0.08240833 0.10313333 0.120066667 0.016933333 6.948236e-01 3.9428e-09 FALSE TRUE
MSTRG.23147.20 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding   15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 0.6820577 0.02245664 1.7922785 0.02245664 0.09419283 5.79516428 0.02856667 0.00340000 0.074433333 0.071033333 3.942800e-09 3.9428e-09 FALSE TRUE
MSTRG.23147.3 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding   15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 1.6076792 0.53948289 3.1762382 0.32378771 0.28953594 2.53570766 0.10988750 0.09783333 0.131400000 0.033566667 7.621534e-01 3.9428e-09 FALSE TRUE
MSTRG.23147.4 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding   15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 1.9051924 0.00000000 2.6099124 0.00000000 0.68908936 8.03337477 0.08361250 0.00000000 0.106733333 0.106733333 5.746622e-07 3.9428e-09 TRUE TRUE
MSTRG.23147.6 ENSG00000163681 HEK293_OSMI2_2hA HEK293_TMG_2hB SLMAP protein_coding   15.78026 6.054856 24.12183 1.040902 1.259095 1.992392 1.6732754 0.29406259 3.1327946 0.29406259 0.75251101 3.36960778 0.07737083 0.03900000 0.132500000 0.093500000 2.078436e-01 3.9428e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163681 E001 0.2903454 0.2806572380 1.000000e+00   3 57755450 57755485 36 + 0.114 0.000 -10.507
ENSG00000163681 E002 0.6674587 0.0268939467 7.900364e-01 8.657001e-01 3 57756230 57756263 34 + 0.161 0.233 0.656
ENSG00000163681 E003 1.0006785 0.0154034796 4.381426e-01 5.800267e-01 3 57756264 57756273 10 + 0.204 0.383 1.240
ENSG00000163681 E004 1.5918646 0.0146781264 9.821576e-01 9.928897e-01 3 57756274 57756281 8 + 0.342 0.383 0.240
ENSG00000163681 E005 7.6611159 0.0224972687 1.727453e-01 2.917699e-01 3 57756282 57756308 27 + 0.888 0.719 -0.670
ENSG00000163681 E006 22.7483201 0.0068610894 2.298951e-01 3.623342e-01 3 57756309 57756342 34 + 1.295 1.238 -0.201
ENSG00000163681 E007 32.2505317 0.0016362449 2.871879e-01 4.276598e-01 3 57756548 57756596 49 + 1.432 1.411 -0.074
ENSG00000163681 E008 65.2210059 0.0076436689 6.287969e-02 1.315092e-01 3 57756597 57756931 335 + 1.739 1.674 -0.219
ENSG00000163681 E009 30.8298954 0.0034198123 1.506951e-02 4.064686e-02 3 57756932 57757012 81 + 1.437 1.288 -0.519
ENSG00000163681 E010 27.4092912 0.0008421595 1.500299e-02 4.049454e-02 3 57757013 57757067 55 + 1.390 1.237 -0.533
ENSG00000163681 E011 31.9750149 0.0006013709 4.913118e-02 1.076053e-01 3 57757068 57757119 52 + 1.442 1.347 -0.330
ENSG00000163681 E012 48.9277809 0.0011104101 1.692924e-02 4.477757e-02 3 57757120 57757235 116 + 1.622 1.526 -0.329
ENSG00000163681 E013 45.4008541 0.0008069628 2.146889e-02 5.457958e-02 3 57757236 57757300 65 + 1.592 1.497 -0.323
ENSG00000163681 E014 61.7777742 0.0075995416 1.088031e-02 3.088189e-02 3 57757301 57757446 146 + 1.727 1.602 -0.422
ENSG00000163681 E015 48.6910043 0.0004729038 3.483636e-03 1.167748e-02 3 57757447 57757553 107 + 1.628 1.497 -0.449
ENSG00000163681 E016 18.1380624 0.0014130074 9.751205e-03 2.815203e-02 3 57757554 57757557 4 + 1.231 1.008 -0.803
ENSG00000163681 E017 95.3227422 0.0003204171 2.809683e-05 1.682320e-04 3 57757558 57757849 292 + 1.914 1.776 -0.466
ENSG00000163681 E018 0.1515154 0.0422519972 1.000000e+00   3 57820613 57820705 93 + 0.061 0.000 -9.399
ENSG00000163681 E019 73.3272753 0.0004256854 1.646170e-04 8.118870e-04 3 57831383 57831530 148 + 1.803 1.658 -0.488
ENSG00000163681 E020 1.2137192 0.0132567117 7.143975e-01 8.106210e-01 3 57831531 57831536 6 + 0.278 0.383 0.653
ENSG00000163681 E021 54.3830278 0.0009963071 1.239666e-01 2.256274e-01 3 57841299 57841371 73 + 1.655 1.624 -0.107
ENSG00000163681 E022 45.4855025 0.0004790822 3.705560e-01 5.149823e-01 3 57847197 57847233 37 + 1.573 1.577 0.014
ENSG00000163681 E023 55.2099185 0.0004085206 8.692842e-02 1.704778e-01 3 57849754 57849816 63 + 1.664 1.623 -0.137
ENSG00000163681 E024 0.1451727 0.0423426632 1.000000e+00   3 57856560 57856648 89 + 0.061 0.000 -9.399
ENSG00000163681 E025 69.7929290 0.0003922744 6.608042e-03 2.020716e-02 3 57857733 57857828 96 + 1.771 1.685 -0.291
ENSG00000163681 E026 69.3848312 0.0003417490 7.387301e-03 2.222455e-02 3 57858088 57858159 72 + 1.768 1.685 -0.284
ENSG00000163681 E027 58.5514569 0.0003835744 3.266422e-05 1.925909e-04 3 57860699 57860759 61 + 1.714 1.516 -0.675
ENSG00000163681 E028 60.8127137 0.0004462348 4.956138e-04 2.143274e-03 3 57860760 57860839 80 + 1.724 1.577 -0.500
ENSG00000163681 E029 31.7632273 0.0005990258 3.726675e-04 1.668200e-03 3 57861949 57861953 5 + 1.463 1.219 -0.849
ENSG00000163681 E030 44.5975100 0.0027592427 1.406584e-02 3.837349e-02 3 57861954 57861999 46 + 1.585 1.467 -0.402
ENSG00000163681 E031 58.7603187 0.0005138322 3.792957e-02 8.721606e-02 3 57862000 57862086 87 + 1.691 1.631 -0.204
ENSG00000163681 E032 32.8804447 0.0012089898 1.201672e-01 2.202335e-01 3 57864548 57864556 9 + 1.447 1.386 -0.208
ENSG00000163681 E033 38.2104506 0.0008231365 3.848415e-01 5.289908e-01 3 57864557 57864572 16 + 1.497 1.497 0.000
ENSG00000163681 E034 35.8125463 0.0103678382 6.638601e-01 7.718234e-01 3 57864573 57864585 13 + 1.463 1.491 0.096
ENSG00000163681 E035 65.4383214 0.0065241723 2.765537e-01 4.160171e-01 3 57864586 57864716 131 + 1.728 1.719 -0.031
ENSG00000163681 E036 33.0742053 0.0042472148 1.324203e-01 2.374421e-01 3 57864807 57864857 51 + 1.451 1.387 -0.222
ENSG00000163681 E037 13.9579526 0.0012366657 6.129505e-01 7.317745e-01 3 57865242 57865292 51 + 1.088 1.090 0.010
ENSG00000163681 E038 30.3020571 0.0320869764 4.562236e-01 5.966766e-01 3 57871636 57871698 63 + 1.406 1.381 -0.086
ENSG00000163681 E039 0.1817044 0.0390310943 1.045811e-01   3 57883961 57884026 66 + 0.000 0.232 13.601
ENSG00000163681 E040 0.0000000       3 57889991 57890040 50 +      
ENSG00000163681 E041 38.1418396 0.0029066021 3.319578e-01 4.755879e-01 3 57890041 57890045 5 + 1.499 1.488 -0.038
ENSG00000163681 E042 38.4396736 0.0062474015 2.736678e-01 4.127436e-01 3 57890046 57890047 2 + 1.505 1.479 -0.089
ENSG00000163681 E043 39.1981811 0.0020624867 2.316545e-01 3.644288e-01 3 57890048 57890056 9 + 1.513 1.488 -0.088
ENSG00000163681 E044 52.4959468 0.0004825203 2.887645e-01 4.293967e-01 3 57890057 57890100 44 + 1.633 1.631 -0.008
ENSG00000163681 E045 1.4038175 0.0101513375 4.943605e-01 6.313079e-01 3 57890101 57891206 1106 + 0.342 0.232 -0.761
ENSG00000163681 E046 0.2998086 0.0290785164 3.069899e-01   3 57896239 57896246 8 + 0.061 0.232 2.235
ENSG00000163681 E047 3.5838736 0.0043137114 7.817770e-01 8.598277e-01 3 57896247 57896339 93 + 0.585 0.583 -0.009
ENSG00000163681 E048 1.8832542 0.0073598439 6.565409e-01 7.660631e-01 3 57896340 57896340 1 + 0.371 0.494 0.654
ENSG00000163681 E049 2.3208486 0.0062866972 9.752502e-01 9.885723e-01 3 57896341 57896371 31 + 0.447 0.494 0.239
ENSG00000163681 E050 0.4513240 0.2006313686 5.714636e-01 6.977504e-01 3 57896372 57896510 139 + 0.114 0.230 1.218
ENSG00000163681 E051 37.7845435 0.0005865289 4.348507e-01 5.771169e-01 3 57896511 57896518 8 + 1.491 1.497 0.022
ENSG00000163681 E052 59.0998289 0.0004662321 2.250998e-01 3.565472e-01 3 57896519 57896591 73 + 1.686 1.678 -0.025
ENSG00000163681 E053 67.2107492 0.0036050591 1.085298e-01 2.033795e-01 3 57896873 57896932 60 + 1.747 1.710 -0.123
ENSG00000163681 E054 0.8105550 0.0148394893 1.000000e+00 1.000000e+00 3 57896933 57902145 5213 + 0.204 0.232 0.240
ENSG00000163681 E055 91.3846489 0.0004350128 6.904464e-01 7.921309e-01 3 57907884 57908006 123 + 1.850 1.930 0.270
ENSG00000163681 E056 0.0000000       3 57908168 57908227 60 +      
ENSG00000163681 E057 68.1475231 0.0110361811 3.204467e-01 4.635766e-01 3 57909076 57909150 75 + 1.710 1.850 0.474
ENSG00000163681 E058 0.5932625 0.1923024022 4.778797e-01 6.163688e-01 3 57912295 57912380 86 + 0.204 0.000 -11.400
ENSG00000163681 E059 92.5600158 0.0150726287 3.479128e-01 4.921342e-01 3 57912381 57912503 123 + 1.842 1.984 0.478
ENSG00000163681 E060 129.7670155 0.0002537507 9.119633e-01 9.481619e-01 3 57912504 57912701 198 + 2.007 2.073 0.224
ENSG00000163681 E061 109.1288777 0.0009521313 6.438599e-01 7.562985e-01 3 57913158 57913275 118 + 1.938 1.981 0.146
ENSG00000163681 E062 78.3908255 0.0003692490 4.409824e-01 5.826264e-01 3 57916906 57916964 59 + 1.786 1.884 0.332
ENSG00000163681 E063 43.8657859 0.0212780207 5.720468e-01 6.982183e-01 3 57916965 57916980 16 + 1.536 1.654 0.402
ENSG00000163681 E064 93.4018325 0.0003646461 3.195594e-01 4.626461e-01 3 57916981 57917077 97 + 1.859 1.965 0.355
ENSG00000163681 E065 8.2897950 0.0448681696 1.929073e-02 4.996658e-02 3 57917078 57918480 1403 + 0.773 1.176 1.503
ENSG00000163681 E066 116.0502185 0.0130842535 3.548261e-01 4.991590e-01 3 57922889 57923023 135 + 1.948 2.073 0.419
ENSG00000163681 E067 85.6355580 0.0074043144 4.168137e-01 5.601880e-01 3 57925845 57925934 90 + 1.821 1.933 0.375
ENSG00000163681 E068 6.1365861 0.0026128398 1.041100e-01 1.967610e-01 3 57925935 57926290 356 + 0.703 0.977 1.068
ENSG00000163681 E069 100.6434201 0.0049178370 9.192579e-02 1.781100e-01 3 57927296 57927513 218 + 1.878 2.030 0.509
ENSG00000163681 E070 417.9316460 0.0154600786 1.308960e-09 1.898473e-08 3 57927514 57930003 2490 + 2.410 2.814 1.346
ENSG00000163681 E071 0.0000000       3 57931659 57931691 33 +