ENSG00000163660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295926 ENSG00000163660 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL1 protein_coding protein_coding 39.82844 17.09014 64.16712 1.650489 1.050298 1.908051 1.936390 1.8517246 2.576238 0.04949577 0.1938802 0.4742153 0.06389167 0.10993333 0.04013333 -0.069800000 6.445012e-08 2.66773e-17 FALSE TRUE
ENST00000464679 ENSG00000163660 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL1 protein_coding retained_intron 39.82844 17.09014 64.16712 1.650489 1.050298 1.908051 12.042414 6.9553363 18.055997 0.68927776 0.6603537 1.3750120 0.32987083 0.40726667 0.28120000 -0.126066667 1.021806e-05 2.66773e-17 FALSE TRUE
ENST00000467081 ENSG00000163660 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL1 protein_coding retained_intron 39.82844 17.09014 64.16712 1.650489 1.050298 1.908051 2.513884 0.0000000 4.600560 0.00000000 0.5527949 8.8487982 0.04404583 0.00000000 0.07156667 0.071566667 2.667730e-17 2.66773e-17 FALSE FALSE
ENST00000471247 ENSG00000163660 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL1 protein_coding retained_intron 39.82844 17.09014 64.16712 1.650489 1.050298 1.908051 3.138088 1.2079934 5.024165 0.04660243 0.4028186 2.0472462 0.08171250 0.07246667 0.07843333 0.005966667 8.781506e-01 2.66773e-17   FALSE
ENST00000474539 ENSG00000163660 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL1 protein_coding retained_intron 39.82844 17.09014 64.16712 1.650489 1.050298 1.908051 3.043794 0.5174315 5.484833 0.01931340 0.3262815 3.3810199 0.06190417 0.03066667 0.08536667 0.054700000 7.780353e-07 2.66773e-17 FALSE TRUE
ENST00000476744 ENSG00000163660 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL1 protein_coding retained_intron 39.82844 17.09014 64.16712 1.650489 1.050298 1.908051 6.237965 4.0073267 9.113922 0.78946751 1.2113937 1.1834184 0.17597083 0.23013333 0.14166667 -0.088466667 1.381652e-01 2.66773e-17 FALSE TRUE
ENST00000478454 ENSG00000163660 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNL1 protein_coding retained_intron 39.82844 17.09014 64.16712 1.650489 1.050298 1.908051 4.504357 0.8535578 7.482074 0.05741470 1.1228386 3.1170006 0.09220417 0.05150000 0.11666667 0.065166667 2.267483e-02 2.66773e-17   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163660 E001 5.4700276 0.0030244332 3.660444e-03 1.218371e-02 3 157146508 157146607 100 - 0.620 1.004 1.520
ENSG00000163660 E002 9.1996261 0.0049224720 1.385812e-03 5.260754e-03 3 157147553 157147794 242 - 0.843 1.197 1.305
ENSG00000163660 E003 7.0908492 0.0158766130 1.390688e-02 3.801591e-02 3 157147795 157147795 1 - 0.753 1.071 1.210
ENSG00000163660 E004 166.0326292 0.0023183597 2.576762e-13 6.909551e-12 3 157147796 157148108 313 - 2.085 2.348 0.877
ENSG00000163660 E005 91.2645742 0.0021026330 1.894828e-06 1.481937e-05 3 157148109 157148120 12 - 1.850 2.059 0.703
ENSG00000163660 E006 114.9004208 0.0024213304 9.847504e-06 6.557107e-05 3 157148121 157148151 31 - 1.959 2.141 0.612
ENSG00000163660 E007 138.3692371 0.0003071327 8.124719e-04 3.303650e-03 3 157148152 157148197 46 - 2.066 2.175 0.366
ENSG00000163660 E008 99.2111335 0.0003143499 2.284572e-02 5.742018e-02 3 157148198 157148200 3 - 1.931 2.018 0.294
ENSG00000163660 E009 125.0706438 0.0002400147 3.773821e-03 1.250834e-02 3 157148201 157148240 40 - 2.026 2.125 0.332
ENSG00000163660 E010 111.6542059 0.0005647640 2.014606e-04 9.700368e-04 3 157148241 157148260 20 - 1.965 2.102 0.461
ENSG00000163660 E011 144.8072495 0.0003056983 2.657440e-05 1.600725e-04 3 157148261 157148315 55 - 2.076 2.210 0.448
ENSG00000163660 E012 329.9651349 0.0002411190 1.392160e-06 1.120441e-05 3 157148316 157148589 274 - 2.443 2.546 0.344
ENSG00000163660 E013 10.5041938 0.0015863714 1.387989e-01 2.464390e-01 3 157148949 157149004 56 - 0.973 1.130 0.574
ENSG00000163660 E014 13.9871371 0.0125192363 2.071689e-01 3.351310e-01 3 157149005 157149286 282 - 1.176 1.026 -0.538
ENSG00000163660 E015 193.1014969 0.0002470031 7.360458e-04 3.029036e-03 3 157149287 157149385 99 - 2.214 2.308 0.313
ENSG00000163660 E016 2.9236855 0.0054248594 1.899468e-01 3.136923e-01 3 157149444 157149484 41 - 0.484 0.697 0.955
ENSG00000163660 E017 216.3261013 0.0015160115 1.089758e-02 3.091838e-02 3 157149485 157149596 112 - 2.268 2.348 0.267
ENSG00000163660 E018 4.6284627 0.0034491935 7.860211e-03 2.342889e-02 3 157149597 157149679 83 - 0.807 0.330 -2.251
ENSG00000163660 E019 5.1683554 0.0031268839 3.544381e-04 1.597281e-03 3 157149680 157149835 156 - 0.866 0.195 -3.481
ENSG00000163660 E020 207.5344006 0.0008476831 2.337506e-02 5.852831e-02 3 157149836 157149940 105 - 2.255 2.321 0.221
ENSG00000163660 E021 93.4301020 0.0048755614 2.507263e-02 6.202579e-02 3 157149941 157149946 6 - 1.897 2.010 0.380
ENSG00000163660 E022 118.4174156 0.0012459833 5.294848e-04 2.269801e-03 3 157149947 157149977 31 - 1.992 2.123 0.440
ENSG00000163660 E023 4.1718521 0.0127977767 1.903381e-01 3.141957e-01 3 157149978 157150064 87 - 0.738 0.514 -0.981
ENSG00000163660 E024 143.3702785 0.0002481606 8.779160e-03 2.573117e-02 3 157150065 157150127 63 - 2.088 2.172 0.281
ENSG00000163660 E025 126.7045726 0.0002967028 2.391105e-03 8.433325e-03 3 157150128 157150169 42 - 2.027 2.131 0.348
ENSG00000163660 E026 2.4055547 0.0061704719 5.738132e-01 6.997295e-01 3 157150170 157150281 112 - 0.535 0.432 -0.509
ENSG00000163660 E027 137.7477353 0.0048546733 5.520281e-01 6.814010e-01 3 157150282 157150381 100 - 2.086 2.117 0.102
ENSG00000163660 E028 228.9313166 0.0003009646 6.102630e-20 3.840947e-18 3 157150382 157151399 1018 - 2.378 2.104 -0.915
ENSG00000163660 E029 48.5461784 0.0004703772 8.831645e-11 1.573229e-09 3 157151400 157151485 86 - 1.738 1.295 -1.519
ENSG00000163660 E030 54.4218790 0.0004123531 8.342711e-10 1.254565e-08 3 157151486 157151591 106 - 1.780 1.395 -1.314
ENSG00000163660 E031 45.5829589 0.0004762183 8.339721e-10 1.254215e-08 3 157151592 157151728 137 - 1.710 1.283 -1.470
ENSG00000163660 E032 70.1540641 0.0004106944 3.800962e-16 1.517238e-14 3 157151729 157151916 188 - 1.898 1.424 -1.612
ENSG00000163660 E033 32.5434474 0.0006092743 2.468107e-03 8.668435e-03 3 157151917 157151930 14 - 1.534 1.308 -0.781
ENSG00000163660 E034 37.9274962 0.0005414848 1.977902e-04 9.543531e-04 3 157151931 157152016 86 - 1.606 1.343 -0.904
ENSG00000163660 E035 40.1425819 0.0005195440 1.818676e-07 1.756840e-06 3 157152017 157152081 65 - 1.648 1.270 -1.303
ENSG00000163660 E036 47.0581251 0.0004616442 1.738141e-07 1.686396e-06 3 157152082 157152176 95 - 1.710 1.365 -1.184
ENSG00000163660 E037 101.8153125 0.0021537292 8.867445e-01 9.315656e-01 3 157152177 157152241 65 - 1.966 1.959 -0.021
ENSG00000163660 E038 27.2679876 0.0014042169 5.189732e-09 6.750749e-08 3 157152242 157152739 498 - 1.509 0.952 -1.978
ENSG00000163660 E039 20.9328318 0.0009602341 7.206839e-08 7.521976e-07 3 157152740 157153035 296 - 1.402 0.825 -2.094
ENSG00000163660 E040 56.4318013 0.0003987037 4.419834e-01 5.836436e-01 3 157153036 157153041 6 - 1.724 1.683 -0.142
ENSG00000163660 E041 147.6717657 0.0002574776 1.305516e-01 2.349244e-01 3 157153042 157153156 115 - 2.140 2.088 -0.173
ENSG00000163660 E042 31.1347537 0.0108447627 2.302365e-10 3.813061e-09 3 157153157 157153498 342 - 1.575 0.861 -2.546
ENSG00000163660 E043 63.7473300 0.0053976678 8.930726e-18 4.420954e-16 3 157153499 157154666 1168 - 1.876 1.199 -2.324
ENSG00000163660 E044 17.9536625 0.0346965057 3.007640e-02 7.210321e-02 3 157156936 157157006 71 - 1.305 1.001 -1.090
ENSG00000163660 E045 9.8053458 0.0499092873 1.185801e-02 3.319195e-02 3 157157007 157157010 4 - 1.085 0.641 -1.727
ENSG00000163660 E046 38.3528664 0.0044639913 2.519820e-03 8.822718e-03 3 157157011 157157022 12 - 1.606 1.375 -0.792
ENSG00000163660 E047 57.2170404 0.0012130227 3.953707e-05 2.281643e-04 3 157157023 157157083 61 - 1.776 1.531 -0.833
ENSG00000163660 E048 8.7461418 0.0022248042 1.767289e-08 2.081231e-07 3 157158665 157158865 201 - 1.079 0.000 -13.597
ENSG00000163660 E049 100.7018947 0.0046324637 8.938760e-02 1.741934e-01 3 157158866 157158914 49 - 1.985 1.892 -0.312
ENSG00000163660 E050 93.0529804 0.0035464435 8.191060e-02 1.625573e-01 3 157158915 157158975 61 - 1.953 1.861 -0.310
ENSG00000163660 E051 0.5869198 0.1391439450 3.326331e-01 4.763105e-01 3 157158976 157159404 429 - 0.242 0.000 -9.849
ENSG00000163660 E052 108.5642412 0.0029888504 5.091457e-02 1.107952e-01 3 157159405 157159479 75 - 2.022 1.929 -0.314
ENSG00000163660 E053 156.7804845 0.0074062482 5.047606e-02 1.100106e-01 3 157159792 157162165 2374 - 2.182 2.075 -0.360