ENSG00000163634

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295899 ENSG00000163634 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC7 protein_coding protein_coding 63.56276 53.64215 88.41543 7.262987 2.253301 0.7208253 37.211893 23.263419 61.889257 1.4373814 2.5959293 1.4112389 0.5619458 0.4425333 0.70236667 0.25983333 0.005505185 0.005505185 FALSE TRUE
ENST00000469584 ENSG00000163634 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC7 protein_coding protein_coding 63.56276 53.64215 88.41543 7.262987 2.253301 0.7208253 3.464844 3.655014 3.949838 0.9474615 0.1230901 0.1116228 0.0581125 0.0720000 0.04473333 -0.02726667 0.606168702 0.005505185 FALSE TRUE
MSTRG.23190.1 ENSG00000163634 HEK293_OSMI2_2hA HEK293_TMG_2hB THOC7 protein_coding   63.56276 53.64215 88.41543 7.262987 2.253301 0.7208253 20.283704 24.386312 20.421144 6.3932190 4.5419565 -0.2558930 0.3409042 0.4418333 0.22860000 -0.21323333 0.075344716 0.005505185 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163634 E001 1.6825347 0.1347147236 2.149664e-01 3.443924e-01 3 63833816 63833869 54 - 0.532 0.254 -1.600
ENSG00000163634 E002 4.9776504 0.0032480991 1.236659e-05 8.042612e-05 3 63833870 63833870 1 - 0.416 1.020 2.559
ENSG00000163634 E003 772.8038668 0.0009226906 8.928549e-08 9.147622e-07 3 63833871 63834199 329 - 2.847 2.938 0.304
ENSG00000163634 E004 410.4075015 0.0001320067 1.109641e-01 2.069646e-01 3 63835154 63835164 11 - 2.605 2.631 0.086
ENSG00000163634 E005 605.4792875 0.0002859265 6.812096e-03 2.073409e-02 3 63835165 63835223 59 - 2.767 2.807 0.133
ENSG00000163634 E006 346.9100533 0.0004562550 5.850962e-03 1.822115e-02 3 63835324 63835326 3 - 2.519 2.575 0.186
ENSG00000163634 E007 591.6855063 0.0011808989 1.495189e-01 2.610130e-01 3 63835327 63835390 64 - 2.762 2.789 0.089
ENSG00000163634 E008 555.1094553 0.0001448440 3.881856e-01 5.322961e-01 3 63836301 63836358 58 - 2.753 2.738 -0.053
ENSG00000163634 E009 437.2788249 0.0001569905 9.655079e-01 9.823289e-01 3 63837976 63837991 16 - 2.645 2.642 -0.011
ENSG00000163634 E010 537.8553817 0.0001423112 6.943975e-01 7.952432e-01 3 63837992 63838062 71 - 2.737 2.728 -0.030
ENSG00000163634 E011 0.1451727 0.0440726802 7.254500e-01   3 63838101 63838371 271 - 0.103 0.000 -9.928
ENSG00000163634 E012 605.7194939 0.0017482208 3.491504e-02 8.149255e-02 3 63838372 63838499 128 - 2.808 2.748 -0.198
ENSG00000163634 E013 300.9475834 0.0012509043 6.201460e-06 4.322910e-05 3 63839656 63839682 27 - 2.532 2.406 -0.419
ENSG00000163634 E014 359.2008412 0.0026001894 9.023502e-06 6.061539e-05 3 63839683 63839773 91 - 2.616 2.469 -0.488
ENSG00000163634 E015 0.6621732 0.2250941478 7.134938e-01 8.099929e-01 3 63839774 63839779 6 - 0.187 0.254 0.566
ENSG00000163634 E016 0.1472490 0.0444988532 7.250397e-01   3 63846104 63846217 114 - 0.103 0.000 -9.929
ENSG00000163634 E017 0.3697384 0.0274424043 1.132531e-01 2.102734e-01 3 63854608 63854742 135 - 0.000 0.253 11.776
ENSG00000163634 E018 18.0055274 0.0129866832 9.180075e-01 9.521799e-01 3 63863504 63863771 268 - 1.277 1.274 -0.010
ENSG00000163634 E019 187.1140677 0.0051413726 7.994194e-04 3.257568e-03 3 63863772 63864083 312 - 2.337 2.177 -0.534
ENSG00000163634 E020 2.8475147 0.0086455760 1.146239e-01 2.122818e-01 3 63864378 63864490 113 - 0.677 0.412 -1.245