ENSG00000163629

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316707 ENSG00000163629 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN13 protein_coding protein_coding 10.44179 2.642318 18.62252 0.1397158 0.1722136 2.812497 1.3074153 1.13246890 1.0181913 0.14343580 0.1918599 -0.1520462 0.20774167 0.425133333 0.05456667 -0.37056667 4.098885e-13 5.658528e-18 FALSE TRUE
ENST00000411767 ENSG00000163629 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN13 protein_coding protein_coding 10.44179 2.642318 18.62252 0.1397158 0.1722136 2.812497 0.9164331 0.09742014 3.6285242 0.09742014 0.6778250 5.0820170 0.06559583 0.036000000 0.19453333 0.15853333 9.393953e-02 5.658528e-18 FALSE TRUE
ENST00000427191 ENSG00000163629 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN13 protein_coding protein_coding 10.44179 2.642318 18.62252 0.1397158 0.1722136 2.812497 3.4045151 0.00000000 5.8824272 0.00000000 0.3718782 9.2027182 0.20567083 0.000000000 0.31620000 0.31620000 5.658528e-18 5.658528e-18 FALSE TRUE
ENST00000511467 ENSG00000163629 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN13 protein_coding protein_coding 10.44179 2.642318 18.62252 0.1397158 0.1722136 2.812497 1.4197444 0.02002703 3.2827982 0.02002703 0.3041352 6.7769084 0.08302917 0.008433333 0.17603333 0.16760000 4.402893e-08 5.658528e-18 FALSE TRUE
MSTRG.25168.5 ENSG00000163629 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN13 protein_coding   10.44179 2.642318 18.62252 0.1397158 0.1722136 2.812497 2.1269725 0.32065052 4.2167082 0.16108168 0.3179422 3.6761554 0.21103333 0.127200000 0.22656667 0.09936667 5.845948e-01 5.658528e-18 FALSE TRUE
MSTRG.25168.7 ENSG00000163629 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPN13 protein_coding   10.44179 2.642318 18.62252 0.1397158 0.1722136 2.812497 0.4940373 0.82076082 0.2977854 0.15788949 0.2167003 -1.4325082 0.13832500 0.307366667 0.01620000 -0.29116667 2.633232e-03 5.658528e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163629 E001 1.0414660 0.0122368821 4.057529e-01 5.493994e-01 4 86594315 86594316 2 + 0.260 0.000 -10.870
ENSG00000163629 E002 35.1596358 0.0005526896 9.281538e-08 9.480049e-07 4 86594317 86594473 157 + 1.447 0.807 -2.315
ENSG00000163629 E003 51.8356925 0.0004113583 5.589163e-07 4.899363e-06 4 86594474 86594731 258 + 1.600 1.163 -1.518
ENSG00000163629 E004 21.1716559 0.0008810944 1.037195e-02 2.967686e-02 4 86594732 86594789 58 + 1.220 0.915 -1.110
ENSG00000163629 E005 0.1472490 0.0434820960 7.585325e-01   4 86595693 86595786 94 + 0.048 0.000 -8.040
ENSG00000163629 E006 32.6378733 0.0005974082 1.348017e-04 6.803541e-04 4 86635252 86635371 120 + 1.405 1.001 -1.433
ENSG00000163629 E007 61.2041831 0.0005214221 7.353515e-09 9.285486e-08 4 86672365 86672543 179 + 1.673 1.189 -1.673
ENSG00000163629 E008 49.0686582 0.0015020679 4.184604e-07 3.759298e-06 4 86686710 86686775 66 + 1.579 1.105 -1.653
ENSG00000163629 E009 74.7927848 0.0004110502 2.691198e-13 7.200104e-12 4 86689005 86689190 186 + 1.763 1.163 -2.072
ENSG00000163629 E010 5.3943974 0.1987074341 5.191835e-03 1.645109e-02 4 86689620 86690303 684 + 0.476 1.213 2.944
ENSG00000163629 E011 46.6321829 0.0004636799 8.248131e-10 1.241821e-08 4 86693587 86693674 88 + 1.565 0.915 -2.307
ENSG00000163629 E012 52.4107485 0.0004271438 3.413099e-08 3.802867e-07 4 86701241 86701434 194 + 1.608 1.105 -1.751
ENSG00000163629 E013 83.0830985 0.0037338986 1.295409e-05 8.381252e-05 4 86701435 86701801 367 + 1.791 1.490 -1.024
ENSG00000163629 E014 56.0212502 0.0003945594 1.522381e-07 1.492654e-06 4 86716530 86716625 96 + 1.633 1.189 -1.538
ENSG00000163629 E015 63.3026774 0.0004515252 6.273782e-09 8.041060e-08 4 86717024 86717117 94 + 1.688 1.214 -1.636
ENSG00000163629 E016 97.9215382 0.0003214482 5.790817e-15 1.973117e-13 4 86722212 86722434 223 + 1.877 1.338 -1.839
ENSG00000163629 E017 55.6921961 0.0004196771 5.614690e-08 5.983252e-07 4 86732400 86732474 75 + 1.632 1.163 -1.627
ENSG00000163629 E018 76.7620386 0.0003889406 2.732978e-05 1.641528e-04 4 86732592 86732766 175 + 1.754 1.489 -0.905
ENSG00000163629 E019 57.0079555 0.0014828466 1.826820e-02 4.771620e-02 4 86734303 86734456 154 + 1.619 1.463 -0.534
ENSG00000163629 E020 57.4102007 0.0098136594 6.033523e-03 1.869931e-02 4 86734737 86734875 139 + 1.632 1.404 -0.781
ENSG00000163629 E021 68.5249854 0.0074897210 7.284798e-04 3.001355e-03 4 86735594 86735746 153 + 1.709 1.449 -0.888
ENSG00000163629 E022 62.5334896 0.0003724102 6.018513e-03 1.866121e-02 4 86741634 86741816 183 + 1.662 1.489 -0.591
ENSG00000163629 E023 60.4629686 0.0005842818 7.157214e-04 2.955153e-03 4 86744966 86745128 163 + 1.653 1.420 -0.798
ENSG00000163629 E024 115.6369110 0.0023223250 3.263917e-09 4.398487e-08 4 86750470 86750887 418 + 1.938 1.581 -1.207
ENSG00000163629 E025 62.1417077 0.0003959466 3.807267e-05 2.206084e-04 4 86751027 86751124 98 + 1.669 1.373 -1.014
ENSG00000163629 E026 29.1392688 0.0006801549 1.021843e-03 4.034366e-03 4 86753009 86753065 57 + 1.354 1.001 -1.256
ENSG00000163629 E027 63.4819487 0.0003878124 1.864545e-05 1.164976e-04 4 86758260 86758349 90 + 1.679 1.373 -1.051
ENSG00000163629 E028 0.1451727 0.0434023963 7.579200e-01   4 86758669 86758677 9 + 0.048 0.000 -8.039
ENSG00000163629 E029 76.6970006 0.0003713179 4.782925e-03 1.532586e-02 4 86758678 86758785 108 + 1.748 1.590 -0.536
ENSG00000163629 E030 80.6131363 0.0007944755 6.086816e-03 1.883982e-02 4 86758942 86759073 132 + 1.769 1.619 -0.509
ENSG00000163629 E031 96.4040968 0.0037837159 7.368489e-04 3.032078e-03 4 86762727 86762953 227 + 1.848 1.647 -0.680
ENSG00000163629 E032 58.0815945 0.0010001059 3.639495e-03 1.212568e-02 4 86762954 86763008 55 + 1.633 1.434 -0.680
ENSG00000163629 E033 104.3334106 0.0002872186 3.149068e-06 2.344500e-05 4 86763009 86763190 182 + 1.887 1.638 -0.842
ENSG00000163629 E034 86.0476207 0.0008378224 1.447800e-04 7.244239e-04 4 86764593 86764724 132 + 1.801 1.580 -0.750
ENSG00000163629 E035 7.7488219 0.0028995955 3.769744e-02 8.676337e-02 4 86764725 86764739 15 + 0.837 0.448 -1.699
ENSG00000163629 E036 74.6858546 0.0005001449 1.288601e-04 6.538812e-04 4 86765395 86765488 94 + 1.742 1.501 -0.819
ENSG00000163629 E037 64.6908447 0.0003743950 1.654103e-03 6.135133e-03 4 86766432 86766517 86 + 1.678 1.476 -0.691
ENSG00000163629 E038 0.0000000       4 86766518 86766653 136 +      
ENSG00000163629 E039 77.9410999 0.0003546770 2.090771e-03 7.504588e-03 4 86767817 86767976 160 + 1.755 1.580 -0.595
ENSG00000163629 E040 95.9925230 0.0026070986 4.530256e-03 1.462832e-02 4 86769769 86769983 215 + 1.843 1.689 -0.519
ENSG00000163629 E041 61.3426013 0.0003905022 2.798285e-01 4.195980e-01 4 86770101 86770199 99 + 1.639 1.590 -0.166
ENSG00000163629 E042 174.3723972 0.0003240361 1.880571e-02 4.890709e-02 4 86771171 86771535 365 + 2.089 2.017 -0.242
ENSG00000163629 E043 108.7913735 0.0002627322 7.373446e-01 8.275628e-01 4 86772778 86772958 181 + 1.870 1.911 0.138
ENSG00000163629 E044 98.0686199 0.0002961496 6.204682e-01 7.376397e-01 4 86774373 86774531 159 + 1.825 1.875 0.169
ENSG00000163629 E045 93.6346597 0.0002783368 2.859841e-01 4.263531e-01 4 86775171 86775342 172 + 1.801 1.881 0.268
ENSG00000163629 E046 106.2067884 0.0012775335 1.539818e-01 2.670863e-01 4 86775442 86775652 211 + 1.851 1.948 0.325
ENSG00000163629 E047 69.9921125 0.0024164933 1.160425e-01 2.143037e-01 4 86780402 86780472 71 + 1.668 1.790 0.414
ENSG00000163629 E048 56.0704595 0.0004210606 6.661492e-03 2.034302e-02 4 86782201 86782262 62 + 1.563 1.756 0.657
ENSG00000163629 E049 74.6792941 0.0018066880 7.608074e-02 1.532381e-01 4 86784465 86784558 94 + 1.697 1.826 0.436
ENSG00000163629 E050 96.0743175 0.0003190856 4.606621e-05 2.618472e-04 4 86785231 86785368 138 + 1.788 2.005 0.731
ENSG00000163629 E051 89.3515382 0.0003119462 2.947202e-08 3.321524e-07 4 86785848 86785936 89 + 1.741 2.028 0.967
ENSG00000163629 E052 81.4260936 0.0005175876 3.202391e-06 2.380925e-05 4 86796874 86796929 56 + 1.709 1.969 0.876
ENSG00000163629 E053 113.6080420 0.0002816354 5.783892e-07 5.056488e-06 4 86799101 86799204 104 + 1.853 2.093 0.807
ENSG00000163629 E054 121.1936573 0.0046765821 3.787932e-05 2.196212e-04 4 86803709 86803857 149 + 1.878 2.122 0.817
ENSG00000163629 E055 77.7189408 0.0009750192 5.357006e-10 8.349392e-09 4 86805279 86805369 91 + 1.664 2.006 1.153
ENSG00000163629 E056 159.3171095 0.0002608954 7.142066e-28 1.001512e-25 4 86807560 86807897 338 + 1.959 2.356 1.327
ENSG00000163629 E057 145.1330472 0.0003546058 7.886872e-33 1.627608e-30 4 86809769 86809984 216 + 1.907 2.351 1.485
ENSG00000163629 E058 80.8795326 0.0003461714 3.120564e-24 3.176688e-22 4 86811046 86811108 63 + 1.639 2.129 1.651
ENSG00000163629 E059 164.2697424 0.0098434242 2.862114e-28 4.148577e-26 4 86814456 86815260 805 + 1.896 2.525 2.103