ENSG00000163626

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421792 ENSG00000163626 HEK293_OSMI2_2hA HEK293_TMG_2hB COX18 protein_coding processed_transcript 6.078448 4.647252 7.403061 0.7279802 0.2951737 0.6705903 0.1783988 0.3008276 0.0000000 0.11168084 0.00000000 -4.9580425 0.03508333 0.07363333 0.00000000 -0.07363333 0.00106826 0.00106826 FALSE  
ENST00000449739 ENSG00000163626 HEK293_OSMI2_2hA HEK293_TMG_2hB COX18 protein_coding nonsense_mediated_decay 6.078448 4.647252 7.403061 0.7279802 0.2951737 0.6705903 4.0852465 3.2046928 4.5971200 0.72699617 0.12986224 0.5191843 0.68284167 0.67560000 0.62243333 -0.05316667 0.68545934 0.00106826 FALSE  
ENST00000507544 ENSG00000163626 HEK293_OSMI2_2hA HEK293_TMG_2hB COX18 protein_coding protein_coding 6.078448 4.647252 7.403061 0.7279802 0.2951737 0.6705903 0.3490614 0.2886296 0.5236898 0.11455559 0.04138056 0.8376446 0.05385000 0.05843333 0.07093333 0.01250000 0.87535558 0.00106826 FALSE  
ENST00000510031 ENSG00000163626 HEK293_OSMI2_2hA HEK293_TMG_2hB COX18 protein_coding nonsense_mediated_decay 6.078448 4.647252 7.403061 0.7279802 0.2951737 0.6705903 1.4598518 0.8531024 2.2822510 0.04486229 0.30229172 1.4091614 0.22657500 0.19233333 0.30663333 0.11430000 0.15782752 0.00106826 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163626 E001 20.687325 0.0125721270 0.46282774 0.60268427 4 73052362 73056079 3718 - 1.368 1.325 -0.150
ENSG00000163626 E002 265.669086 0.0014515041 0.00555642 0.01743659 4 73056080 73058113 2034 - 2.403 2.463 0.198
ENSG00000163626 E003 51.573196 0.0004810188 0.27832744 0.41799752 4 73058114 73058287 174 - 1.744 1.705 -0.133
ENSG00000163626 E004 36.785603 0.0005587067 0.12790121 0.23124458 4 73061813 73061920 108 - 1.618 1.545 -0.247
ENSG00000163626 E005 41.279191 0.0009856647 0.70549942 0.80385428 4 73064778 73064899 122 - 1.643 1.637 -0.022
ENSG00000163626 E006 7.097322 0.0024161169 0.39778450 0.54154388 4 73064900 73064902 3 - 0.959 0.872 -0.330
ENSG00000163626 E007 46.923996 0.0006264263 0.06942477 0.14240280 4 73065250 73065413 164 - 1.724 1.645 -0.266
ENSG00000163626 E008 33.820879 0.0007144416 0.16188469 0.27758672 4 73068029 73068129 101 - 1.581 1.511 -0.240
ENSG00000163626 E009 3.378771 0.0779784008 0.34394137 0.48799212 4 73068130 73068133 4 - 0.714 0.519 -0.859
ENSG00000163626 E010 2.094101 0.0769441544 0.28990768 0.43066731 4 73068551 73068659 109 - 0.379 0.567 0.947
ENSG00000163626 E011 41.892698 0.0223509286 0.41523994 0.55863172 4 73069317 73069755 439 - 1.609 1.661 0.177