ENSG00000163624

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295887 ENSG00000163624 HEK293_OSMI2_2hA HEK293_TMG_2hB CDS1 protein_coding protein_coding 5.801408 1.966027 8.151826 0.1304346 0.1552956 2.046289 4.1790915 1.6175008 5.5259295 0.2582170 0.1330658 1.766167 0.7534375 0.82070000 0.67813333 -0.142566667 0.381337458 0.004122356 FALSE TRUE
MSTRG.25105.1 ENSG00000163624 HEK293_OSMI2_2hA HEK293_TMG_2hB CDS1 protein_coding   5.801408 1.966027 8.151826 0.1304346 0.1552956 2.046289 1.0442029 0.1688236 1.8873124 0.0347252 0.1797163 3.407348 0.1404542 0.08576667 0.23103333 0.145266667 0.004122356 0.004122356 FALSE TRUE
MSTRG.25105.4 ENSG00000163624 HEK293_OSMI2_2hA HEK293_TMG_2hB CDS1 protein_coding   5.801408 1.966027 8.151826 0.1304346 0.1552956 2.046289 0.5781138 0.1797023 0.7385841 0.1797023 0.0380844 1.980427 0.1061292 0.09353333 0.09086667 -0.002666667 0.587968903 0.004122356 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163624 E001 4.575920 0.0035748508 5.260724e-01 6.593498e-01 4 84583061 84583077 17 + 0.719 0.615 -0.441
ENSG00000163624 E002 6.804139 0.0023783895 7.373784e-02 1.495084e-01 4 84583078 84583126 49 + 0.891 0.615 -1.119
ENSG00000163624 E003 11.542724 0.0015609653 1.149631e-02 3.234056e-02 4 84583127 84583267 141 + 1.104 0.778 -1.228
ENSG00000163624 E004 5.926382 0.0120095109 6.709423e-02 1.385298e-01 4 84583268 84583268 1 + 0.851 0.543 -1.291
ENSG00000163624 E005 20.586929 0.0045819904 2.036789e-02 5.225883e-02 4 84583269 84583518 250 + 1.322 1.088 -0.832
ENSG00000163624 E006 23.982657 0.0030874935 5.535810e-03 1.738055e-02 4 84604243 84604370 128 + 1.390 1.130 -0.917
ENSG00000163624 E007 24.412462 0.0007483683 2.198118e-02 5.563559e-02 4 84609429 84609525 97 + 1.387 1.186 -0.704
ENSG00000163624 E008 27.820236 0.0010364049 3.740868e-03 1.241345e-02 4 84617564 84617661 98 + 1.449 1.204 -0.857
ENSG00000163624 E009 35.881344 0.0088170076 2.892164e-02 6.984928e-02 4 84619394 84619533 140 + 1.546 1.358 -0.646
ENSG00000163624 E010 29.801885 0.0021796024 2.248219e-02 5.668934e-02 4 84631819 84631877 59 + 1.467 1.281 -0.646
ENSG00000163624 E011 33.226420 0.0006650960 7.316938e-01 8.233038e-01 4 84633857 84633939 83 + 1.480 1.454 -0.086
ENSG00000163624 E012 33.144125 0.0011771173 8.201294e-02 1.626969e-01 4 84635264 84635351 88 + 1.501 1.371 -0.449
ENSG00000163624 E013 29.439681 0.0306903466 3.798637e-01 5.241258e-01 4 84638924 84638992 69 + 1.447 1.353 -0.323
ENSG00000163624 E014 53.933856 0.0004922386 4.631140e-01 6.029480e-01 4 84640838 84640990 153 + 1.692 1.650 -0.140
ENSG00000163624 E015 31.435559 0.0006833260 7.368469e-01 8.271922e-01 4 84643024 84643143 120 + 1.460 1.435 -0.085
ENSG00000163624 E016 36.487925 0.0057689559 3.404259e-01 4.843893e-01 4 84645222 84645325 104 + 1.498 1.569 0.241
ENSG00000163624 E017 38.627771 0.0066273854 2.815606e-01 4.214666e-01 4 84648557 84648680 124 + 1.553 1.465 -0.303
ENSG00000163624 E018 287.998851 0.0002551746 1.908284e-18 1.016073e-16 4 84648681 84651334 2654 + 2.353 2.512 0.528
ENSG00000163624 E019 0.294498 0.3538127660 1.000000e+00   4 84653276 84653327 52 + 0.127 0.001 -7.921