ENSG00000163608

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314400 ENSG00000163608 HEK293_OSMI2_2hA HEK293_TMG_2hB NEPRO protein_coding protein_coding 24.30152 8.666294 39.04705 0.5881124 1.119533 2.170432 4.2262191 1.8813843 7.0026318 0.3743456 0.1592349 1.89051350 0.19506250 0.21416667 0.179433333 -0.03473333 6.450461e-01 1.856864e-08 FALSE TRUE
ENST00000469809 ENSG00000163608 HEK293_OSMI2_2hA HEK293_TMG_2hB NEPRO protein_coding nonsense_mediated_decay 24.30152 8.666294 39.04705 0.5881124 1.119533 2.170432 0.7468409 1.3498875 0.3040322 1.3498875 0.1521496 -2.11450311 0.05282083 0.13713333 0.007933333 -0.12920000 9.512096e-01 1.856864e-08 FALSE TRUE
ENST00000472637 ENSG00000163608 HEK293_OSMI2_2hA HEK293_TMG_2hB NEPRO protein_coding nonsense_mediated_decay 24.30152 8.666294 39.04705 0.5881124 1.119533 2.170432 2.4833737 2.7188032 2.8152033 0.3060560 0.3768668 0.05008629 0.15099583 0.32093333 0.071833333 -0.24910000 2.214016e-06 1.856864e-08 FALSE TRUE
ENST00000473284 ENSG00000163608 HEK293_OSMI2_2hA HEK293_TMG_2hB NEPRO protein_coding nonsense_mediated_decay 24.30152 8.666294 39.04705 0.5881124 1.119533 2.170432 5.6440053 0.6511556 10.6309438 0.3372831 1.5398284 4.00849244 0.17353333 0.08063333 0.272000000 0.19136667 3.637271e-01 1.856864e-08 FALSE TRUE
ENST00000474311 ENSG00000163608 HEK293_OSMI2_2hA HEK293_TMG_2hB NEPRO protein_coding retained_intron 24.30152 8.666294 39.04705 0.5881124 1.119533 2.170432 2.7001056 0.6215045 3.3850099 0.2215998 0.1670201 2.42655087 0.12642917 0.07556667 0.087100000 0.01153333 8.192527e-01 1.856864e-08 FALSE TRUE
MSTRG.23436.3 ENSG00000163608 HEK293_OSMI2_2hA HEK293_TMG_2hB NEPRO protein_coding   24.30152 8.666294 39.04705 0.5881124 1.119533 2.170432 2.7382094 0.6275417 4.3940942 0.4359222 0.5245249 2.78825379 0.09613333 0.07760000 0.112200000 0.03460000 6.756731e-01 1.856864e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163608 E001 227.119438 0.0171621093 6.180655e-01 7.357945e-01 3 113002444 113004565 2122 - 2.278 2.350 0.241
ENSG00000163608 E002 56.509276 0.0004398512 2.065693e-02 5.286298e-02 3 113004566 113004916 351 - 1.724 1.617 -0.365
ENSG00000163608 E003 23.255365 0.0094408021 8.390965e-01 8.994399e-01 3 113004917 113004953 37 - 1.328 1.331 0.012
ENSG00000163608 E004 41.505523 0.0005529423 4.771811e-07 4.237591e-06 3 113004954 113004963 10 - 1.472 1.783 1.057
ENSG00000163608 E005 150.510126 0.0093185331 2.461256e-09 3.393684e-08 3 113004964 113005175 212 - 2.004 2.356 1.177
ENSG00000163608 E006 89.673409 0.0084501135 2.737974e-08 3.106180e-07 3 113005176 113005242 67 - 1.782 2.136 1.189
ENSG00000163608 E007 57.167505 0.0314279115 2.000043e-03 7.225882e-03 3 113005243 113005263 21 - 1.588 1.945 1.209
ENSG00000163608 E008 121.267050 0.0009993406 5.940556e-07 5.179348e-06 3 113005264 113005321 58 - 1.966 2.175 0.701
ENSG00000163608 E009 177.088051 0.0023274622 4.909186e-03 1.567714e-02 3 113005322 113005480 159 - 2.155 2.284 0.431
ENSG00000163608 E010 395.546029 0.0001325827 9.606703e-01 9.792318e-01 3 113005481 113005943 463 - 2.530 2.555 0.083
ENSG00000163608 E011 113.186467 0.0039532593 4.864859e-01 6.242306e-01 3 113005944 113006004 61 - 1.997 1.984 -0.045
ENSG00000163608 E012 233.495949 0.0009641210 1.321904e-03 5.049923e-03 3 113008171 113008430 260 - 2.325 2.249 -0.253
ENSG00000163608 E013 10.044069 0.0017588054 3.244366e-02 7.670861e-02 3 113008431 113008800 370 - 1.037 0.776 -0.992
ENSG00000163608 E014 4.629932 0.1016005823 2.941066e-01 4.351885e-01 3 113009498 113009584 87 - 0.747 0.539 -0.898
ENSG00000163608 E015 6.369756 0.0025622880 1.294842e-04 6.565601e-04 3 113010504 113010642 139 - 0.912 0.210 -3.527
ENSG00000163608 E016 85.289325 0.0010705048 4.358522e-03 1.414442e-02 3 113010643 113010657 15 - 1.902 1.787 -0.387
ENSG00000163608 E017 101.179749 0.0040069046 3.192686e-02 7.571443e-02 3 113010658 113010704 47 - 1.969 1.878 -0.306
ENSG00000163608 E018 69.553522 0.0004474566 1.157152e-02 3.251735e-02 3 113011045 113011055 11 - 1.811 1.705 -0.360
ENSG00000163608 E019 92.594402 0.0003184272 4.110894e-03 1.345374e-02 3 113011056 113011092 37 - 1.933 1.829 -0.350
ENSG00000163608 E020 105.637538 0.0003748605 2.017871e-03 7.281811e-03 3 113011093 113011165 73 - 1.988 1.882 -0.358
ENSG00000163608 E021 95.163812 0.0128610005 1.826534e-01 3.045140e-01 3 113011166 113011261 96 - 1.935 1.861 -0.249
ENSG00000163608 E022 91.232754 0.0244842005 6.032637e-01 7.240800e-01 3 113011262 113011379 118 - 1.906 1.881 -0.084
ENSG00000163608 E023 61.715772 0.0150867823 5.195921e-02 1.126570e-01 3 113011380 113011406 27 - 1.763 1.622 -0.477
ENSG00000163608 E024 7.333408 0.0058358075 3.423459e-02 8.020826e-02 3 113011407 113011536 130 - 0.921 0.614 -1.237
ENSG00000163608 E025 7.995143 0.0020612465 4.404378e-02 9.846601e-02 3 113012539 113012576 38 - 0.947 0.675 -1.073
ENSG00000163608 E026 12.266977 0.0014420193 1.058163e-03 4.160338e-03 3 113012577 113012733 157 - 1.134 0.728 -1.536
ENSG00000163608 E027 74.248466 0.0112750631 1.959209e-01 3.211254e-01 3 113012734 113012792 59 - 1.828 1.755 -0.246
ENSG00000163608 E028 56.060358 0.0004566570 5.202769e-01 6.542511e-01 3 113012793 113012811 19 - 1.695 1.683 -0.041
ENSG00000163608 E029 8.732447 0.0018834622 1.685855e-02 4.461864e-02 3 113012812 113013271 460 - 0.994 0.675 -1.250
ENSG00000163608 E030 41.701906 0.0011121149 5.638332e-01 6.912393e-01 3 113013272 113013274 3 - 1.552 1.610 0.201
ENSG00000163608 E031 68.774463 0.0004432368 6.907802e-01 7.923747e-01 3 113013275 113013330 56 - 1.779 1.783 0.012
ENSG00000163608 E032 69.815775 0.0010804082 4.156021e-02 9.392844e-02 3 113013331 113013361 31 - 1.806 1.721 -0.286
ENSG00000163608 E033 74.937966 0.0014967353 4.945057e-02 1.081823e-01 3 113013362 113013403 42 - 1.835 1.756 -0.267
ENSG00000163608 E034 5.668174 0.0556493436 4.673932e-01 6.068884e-01 3 113013949 113013952 4 - 0.798 0.676 -0.498
ENSG00000163608 E035 93.225756 0.0003351566 3.993049e-04 1.771721e-03 3 113013953 113014032 80 - 1.941 1.805 -0.459
ENSG00000163608 E036 75.434322 0.0003639180 3.317204e-04 1.507471e-03 3 113017448 113017602 155 - 1.853 1.694 -0.535
ENSG00000163608 E037 2.152976 0.0068153749 1.256148e-01 2.280290e-01 3 113019066 113019160 95 - 0.507 0.210 -1.834
ENSG00000163608 E038 74.964459 0.0211556504 4.473271e-02 9.971498e-02 3 113019542 113019861 320 - 1.849 1.697 -0.515