ENSG00000163602

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000477973 ENSG00000163602 HEK293_OSMI2_2hA HEK293_TMG_2hB RYBP protein_coding protein_coding 10.31577 4.358986 17.36818 0.7629904 0.3724363 1.991907 1.740873 0.8472585 3.583897 0.02509954 0.06622886 2.067747 0.17018333 0.2034000 0.2065000 0.0031000 9.280640e-01 2.607019e-09 FALSE FALSE
ENST00000676841 ENSG00000163602 HEK293_OSMI2_2hA HEK293_TMG_2hB RYBP protein_coding retained_intron 10.31577 4.358986 17.36818 0.7629904 0.3724363 1.991907 0.558627 0.0000000 1.748205 0.00000000 0.19576581 7.457960 0.03565417 0.0000000 0.1011000 0.1011000 2.607019e-09 2.607019e-09 FALSE FALSE
ENST00000677329 ENSG00000163602 HEK293_OSMI2_2hA HEK293_TMG_2hB RYBP protein_coding processed_transcript 10.31577 4.358986 17.36818 0.7629904 0.3724363 1.991907 7.982930 3.5017995 12.016121 0.74406310 0.48987405 1.775889 0.78690000 0.7937333 0.6912667 -0.1024667 8.287607e-02 2.607019e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163602 E001 66.2312702 0.0004055953 1.253949e-05 8.146388e-05 3 72371825 72374501 2677 - 1.664 1.965 1.013
ENSG00000163602 E002 719.9582259 0.0171809474 4.965956e-05 2.800707e-04 3 72374502 72376949 2448 - 2.713 2.951 0.791
ENSG00000163602 E003 446.4977225 0.0047321739 1.760122e-06 1.385795e-05 3 72376950 72378637 1688 - 2.584 2.523 -0.205
ENSG00000163602 E004 105.4409014 0.0013225653 2.498539e-06 1.903796e-05 3 72379040 72379138 99 - 1.972 1.857 -0.385
ENSG00000163602 E005 1.9324608 0.0088523462 1.479336e-01 2.588658e-01 3 72379139 72379197 59 - 0.462 0.223 -1.500
ENSG00000163602 E006 137.0077164 0.0045469203 2.624608e-07 2.458342e-06 3 72379251 72379427 177 - 2.092 1.931 -0.541
ENSG00000163602 E007 0.8868276 0.0738400665 3.984485e-01 5.422024e-01 3 72379428 72380231 804 - 0.168 0.372 1.516
ENSG00000163602 E008 0.2987644 0.0274874699 9.628488e-01   3 72380232 72380630 399 - 0.119 0.001 -7.225
ENSG00000163602 E009 76.9413808 0.0395525477 9.525163e-03 2.760081e-02 3 72446496 72446621 126 - 1.849 1.643 -0.698