ENSG00000163597

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000364968 ENSG00000163597 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG16 lncRNA snoRNA 120.3648 183.1842 85.69535 27.61804 2.25231 -1.095917 6.767331 4.010873 8.544132 1.855631 1.17145074 1.0891126 0.06602083 0.02013333 0.09916667 0.07903333 6.447652e-05 7.265359e-85   FALSE
ENST00000586942 ENSG00000163597 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG16 lncRNA lncRNA 120.3648 183.1842 85.69535 27.61804 2.25231 -1.095917 3.466750 0.000000 5.760566 0.000000 0.09803001 9.1725691 0.04082917 0.00000000 0.06726667 0.06726667 7.265359e-85 7.265359e-85   FALSE
ENST00000590435 ENSG00000163597 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG16 lncRNA lncRNA 120.3648 183.1842 85.69535 27.61804 2.25231 -1.095917 20.202838 63.962687 0.000000 20.177851 0.00000000 -12.6432404 0.10542083 0.33493333 0.00000000 -0.33493333 7.250638e-34 7.265359e-85   FALSE
ENST00000661348 ENSG00000163597 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG16 lncRNA lncRNA 120.3648 183.1842 85.69535 27.61804 2.25231 -1.095917 56.357096 89.845483 31.535620 9.085268 0.66898885 -1.5101668 0.45677083 0.49790000 0.36816667 -0.12973333 1.724578e-02 7.265359e-85   FALSE
ENST00000670737 ENSG00000163597 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG16 lncRNA lncRNA 120.3648 183.1842 85.69535 27.61804 2.25231 -1.095917 20.282449 14.428357 22.734399 2.758120 1.57889123 0.6556047 0.19966250 0.08523333 0.26556667 0.18033333 4.448686e-03 7.265359e-85   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163597 E001 0.4804688 0.0214289187 2.035046e-01 3.305978e-01 17 76557733 76557756 24 + 0.235 0.112 -1.287
ENSG00000163597 E002 0.8073459 0.0267313233 1.839520e-01 3.061777e-01 17 76557757 76557765 9 + 0.318 0.201 -0.872
ENSG00000163597 E003 0.8073459 0.0267313233 1.839520e-01 3.061777e-01 17 76557766 76557766 1 + 0.318 0.201 -0.872
ENSG00000163597 E004 1.7305162 0.0088225882 8.303792e-01 8.935692e-01 17 76557767 76557768 2 + 0.318 0.525 1.124
ENSG00000163597 E005 4.8938930 0.0562976164 3.872530e-01 5.313992e-01 17 76557769 76557777 9 + 0.725 0.812 0.347
ENSG00000163597 E006 212.2614644 0.0090894746 8.104869e-11 1.452368e-09 17 76557778 76557791 14 + 2.370 2.287 -0.277
ENSG00000163597 E007 255.0363057 0.0068060863 8.670815e-11 1.547052e-09 17 76557792 76557795 4 + 2.424 2.386 -0.128
ENSG00000163597 E008 523.0882890 0.0041846995 2.859607e-10 4.670610e-09 17 76557796 76557857 62 + 2.687 2.729 0.143
ENSG00000163597 E009 36.4380047 0.0006175421 1.296752e-40 4.688277e-38 17 76557858 76557969 112 + 1.801 1.285 -1.769
ENSG00000163597 E010 49.9386494 0.0004612377 1.783904e-69 2.640275e-66 17 76557970 76558279 310 + 1.969 1.329 -2.180
ENSG00000163597 E011 25.2879448 0.0010964480 6.547857e-35 1.598546e-32 17 76558280 76558373 94 + 1.672 1.053 -2.158
ENSG00000163597 E012 71.1514000 0.0095162567 1.809146e-22 1.521399e-20 17 76558374 76558600 227 + 2.030 1.666 -1.225
ENSG00000163597 E013 33.0485602 0.0006575853 3.992048e-41 1.477112e-38 17 76558601 76558790 190 + 1.775 1.212 -1.936
ENSG00000163597 E014 33.5361749 0.0012505163 2.253322e-36 6.010437e-34 17 76558791 76558944 154 + 1.765 1.243 -1.793
ENSG00000163597 E015 239.5512432 0.0028940655 1.079437e-20 7.529312e-19 17 76558945 76559043 99 + 2.411 2.349 -0.205
ENSG00000163597 E016 61.0375869 0.0053687503 2.729405e-32 5.375028e-30 17 76559044 76560433 1390 + 1.985 1.564 -1.424
ENSG00000163597 E017 4.5297427 0.0034551361 1.232882e-02 3.432268e-02 17 76561043 76561097 55 + 0.806 0.684 -0.494
ENSG00000163597 E018 395.0917389 0.0009921563 4.580677e-09 6.015496e-08 17 76561288 76561293 6 + 2.514 2.641 0.424
ENSG00000163597 E019 723.6471118 0.0033852653 1.312985e-07 1.303948e-06 17 76561294 76561398 105 + 2.790 2.892 0.337
ENSG00000163597 E020 20.0838991 0.0040328832 6.916006e-02 1.419812e-01 17 76561399 76561402 4 + 1.253 1.357 0.365
ENSG00000163597 E021 22.8566797 0.0008091282 2.351993e-14 7.322565e-13 17 76561403 76561633 231 + 1.519 1.235 -0.982
ENSG00000163597 E022 16.8050905 0.0019275320 9.693925e-12 2.025014e-10 17 76561634 76561751 118 + 1.400 1.086 -1.106
ENSG00000163597 E023 1266.7650470 0.0024241867 8.483772e-14 2.436297e-12 17 76563119 76563482 364 + 3.044 3.128 0.280
ENSG00000163597 E024 1066.9138314 0.0046602116 3.386751e-11 6.463280e-10 17 76563483 76563972 490 + 2.995 3.038 0.144
ENSG00000163597 E025 5198.7540889 0.0097477841 8.967700e-29 1.353708e-26 17 76563973 76565357 1385 + 3.274 3.863 1.955