ENSG00000163510

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000404136 ENSG00000163510 HEK293_OSMI2_2hA HEK293_TMG_2hB CWC22 protein_coding protein_coding 11.92556 3.303592 19.41916 0.4338993 0.686901 2.551756 4.523565 0.5218945 8.040423 0.1387755 0.3170057 3.919852 0.3065292 0.1536 0.4139333 0.2603333 1.275881e-06 1.267871e-06 FALSE TRUE
ENST00000410053 ENSG00000163510 HEK293_OSMI2_2hA HEK293_TMG_2hB CWC22 protein_coding protein_coding 11.92556 3.303592 19.41916 0.4338993 0.686901 2.551756 7.401994 2.7816974 11.378737 0.3329561 0.3717173 2.028393 0.6934708 0.8464 0.5860667 -0.2603333 1.267871e-06 1.267871e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163510 E001 224.51043 0.0001780182 1.463234e-16 6.171086e-15 2 179944876 179945620 745 - 2.195 2.413 0.725
ENSG00000163510 E002 87.24789 0.0003192877 4.586714e-01 5.989834e-01 2 179945621 179945715 95 - 1.833 1.867 0.116
ENSG00000163510 E003 141.27955 0.0014110815 2.171119e-01 3.469143e-01 2 179950512 179950732 221 - 2.038 2.087 0.166
ENSG00000163510 E004 93.28413 0.0004460953 3.491762e-01 4.933944e-01 2 179950825 179950926 102 - 1.862 1.904 0.142
ENSG00000163510 E005 83.55874 0.0003485140 5.017673e-01 6.379111e-01 2 179952471 179952598 128 - 1.818 1.849 0.107
ENSG00000163510 E006 85.42262 0.0003029778 2.732391e-02 6.665413e-02 2 179954205 179954357 153 - 1.811 1.912 0.341
ENSG00000163510 E007 71.10870 0.0004099523 2.129053e-02 5.419816e-02 2 179954957 179955034 78 - 1.729 1.845 0.391
ENSG00000163510 E008 67.16787 0.0011484426 4.171706e-01 5.605605e-01 2 179959022 179959082 61 - 1.721 1.765 0.151
ENSG00000163510 E009 80.61282 0.0014068169 9.923942e-01 9.993308e-01 2 179964547 179964628 82 - 1.807 1.807 0.001
ENSG00000163510 E010 91.89293 0.0073490257 9.014755e-01 9.412112e-01 2 179965878 179965982 105 - 1.863 1.869 0.020
ENSG00000163510 E011 64.01450 0.0113129169 4.035643e-01 5.473333e-01 2 179970501 179970563 63 - 1.722 1.656 -0.226
ENSG00000163510 E012 103.88809 0.0002820149 3.543359e-02 8.248492e-02 2 179970650 179970856 207 - 1.933 1.836 -0.329
ENSG00000163510 E013 76.65649 0.0004696398 1.500948e-02 4.050918e-02 2 179970941 179971076 136 - 1.809 1.674 -0.456
ENSG00000163510 E014 44.92702 0.0004931039 9.956352e-02 1.898160e-01 2 179973193 179973246 54 - 1.578 1.461 -0.402
ENSG00000163510 E015 59.90158 0.0004009832 1.521163e-01 2.645599e-01 2 179973634 179973802 169 - 1.696 1.609 -0.297
ENSG00000163510 E016 59.60442 0.0028138965 2.373634e-03 8.379352e-03 2 179978190 179978318 129 - 1.715 1.502 -0.723
ENSG00000163510 E017 102.50597 0.0003007399 2.408453e-06 1.841003e-05 2 179981752 179981997 246 - 1.949 1.713 -0.798
ENSG00000163510 E018 78.55985 0.0003627688 2.065801e-02 5.286430e-02 2 179986695 179986805 111 - 1.819 1.694 -0.425
ENSG00000163510 E019 59.88901 0.0004063229 9.944527e-04 3.939198e-03 2 179988577 179988644 68 - 1.716 1.502 -0.727
ENSG00000163510 E020 66.68052 0.0026575512 1.267744e-01 2.296589e-01 2 179993315 179993454 140 - 1.743 1.647 -0.326
ENSG00000163510 E021 0.00000       2 180006867 180007069 203 -      
ENSG00000163510 E022 35.83806 0.0005722188 5.544251e-02 1.187457e-01 2 180007070 180007297 228 - 1.488 1.333 -0.534