ENSG00000163491

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341435 ENSG00000163491 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK10 protein_coding protein_coding 1.04981 0.4634629 1.695425 0.04964595 0.05094124 1.848808 0.28985612 0.04138238 0.54236619 0.04138238 0.16485683 3.4262795 0.23365833 0.10823333 0.31950000 0.21126667 0.362079194 0.001865574 FALSE TRUE
ENST00000424275 ENSG00000163491 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK10 protein_coding protein_coding 1.04981 0.4634629 1.695425 0.04964595 0.05094124 1.848808 0.12190987 0.03066335 0.16093596 0.03066335 0.11054414 2.0716549 0.12496250 0.08020000 0.09723333 0.01703333 0.941202713 0.001865574 FALSE TRUE
ENST00000429845 ENSG00000163491 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK10 protein_coding protein_coding 1.04981 0.4634629 1.695425 0.04964595 0.05094124 1.848808 0.06263507 0.03474109 0.18523713 0.03474109 0.03369914 2.1255551 0.06219167 0.06276667 0.10980000 0.04703333 0.693409038 0.001865574 FALSE TRUE
ENST00000435584 ENSG00000163491 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK10 protein_coding protein_coding 1.04981 0.4634629 1.695425 0.04964595 0.05094124 1.848808 0.17485766 0.23874711 0.04152354 0.12080800 0.04152354 -2.2713762 0.22414167 0.47410000 0.02313333 -0.45096667 0.171209257 0.001865574 FALSE TRUE
ENST00000435750 ENSG00000163491 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK10 protein_coding protein_coding 1.04981 0.4634629 1.695425 0.04964595 0.05094124 1.848808 0.14612766 0.00000000 0.39096114 0.00000000 0.06406167 5.3253905 0.09315000 0.00000000 0.22940000 0.22940000 0.001865574 0.001865574 FALSE FALSE
ENST00000691995 ENSG00000163491 HEK293_OSMI2_2hA HEK293_TMG_2hB NEK10 protein_coding protein_coding 1.04981 0.4634629 1.695425 0.04964595 0.05094124 1.848808 0.08450463 0.07295878 0.14231882 0.02890752 0.01563639 0.8766275 0.12695833 0.15710000 0.08353333 -0.07356667 0.451224352 0.001865574 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163491 E001 6.3307463 0.003554056 0.00451824 0.01459574 3 27106484 27110084 3601 - 0.704 1.049 1.332
ENSG00000163491 E002 3.0592958 0.005304955 0.77510954 0.85508889 3 27110085 27110902 818 - 0.561 0.602 0.184
ENSG00000163491 E003 0.7771569 0.015947532 0.96105898 0.97947517 3 27110903 27110903 1 - 0.232 0.204 -0.230
ENSG00000163491 E004 4.7046429 0.005568325 0.17114594 0.28967287 3 27110904 27111271 368 - 0.656 0.845 0.769
ENSG00000163491 E005 1.5540973 0.011120911 0.01175869 0.03295485 3 27111272 27111320 49 - 0.232 0.662 2.351
ENSG00000163491 E006 2.1904351 0.085968174 0.09004520 0.17520458 3 27115940 27115995 56 - 0.349 0.666 1.557
ENSG00000163491 E007 2.1861687 0.075532603 0.08535130 0.16797610 3 27116075 27116127 53 - 0.349 0.666 1.557
ENSG00000163491 E008 2.5559097 0.036408904 0.42977375 0.57243672 3 27119760 27119868 109 - 0.468 0.603 0.634
ENSG00000163491 E009 1.0413643 0.102622828 0.75514405 0.84056708 3 27131880 27131951 72 - 0.275 0.340 0.430
ENSG00000163491 E010 1.0694769 0.012289778 0.23134079 0.36408414 3 27131952 27131990 39 - 0.232 0.447 1.353
ENSG00000163491 E011 1.5176804 0.009132097 0.57656660 0.70196302 3 27141482 27141582 101 - 0.349 0.447 0.546
ENSG00000163491 E012 0.0000000       3 27143445 27143474 30 -      
ENSG00000163491 E013 0.1451727 0.043853583 1.00000000   3 27162266 27162460 195 - 0.070 0.000 -9.509
ENSG00000163491 E014 0.1451727 0.043853583 1.00000000   3 27162461 27162601 141 - 0.070 0.000 -9.509
ENSG00000163491 E015 1.0738451 0.012871774 0.60742966 0.72741091 3 27162701 27162738 38 - 0.313 0.204 -0.815
ENSG00000163491 E016 1.8165466 0.008432917 0.20195694 0.32865015 3 27171819 27171873 55 - 0.468 0.204 -1.690
ENSG00000163491 E017 1.1845624 0.010941208 0.09205793 0.17832282 3 27174439 27174440 2 - 0.382 0.000 -12.509
ENSG00000163491 E018 1.3360778 0.009886449 0.06753468 0.13925100 3 27174441 27174525 85 - 0.413 0.000 -12.679
ENSG00000163491 E019 1.6242331 0.008352772 0.03715987 0.08577937 3 27174650 27174833 184 - 0.468 0.000 -12.968
ENSG00000163491 E020 2.8972861 0.163880716 0.63109137 0.74619286 3 27192029 27192242 214 - 0.581 0.449 -0.633
ENSG00000163491 E021 0.0000000       3 27194061 27194231 171 -      
ENSG00000163491 E022 0.0000000       3 27194537 27194676 140 -      
ENSG00000163491 E023 1.6868011 0.037298096 0.77166706 0.85260965 3 27201510 27201580 71 - 0.412 0.343 -0.398
ENSG00000163491 E024 2.7219364 0.041175315 0.98407516 0.99413474 3 27202428 27202556 129 - 0.540 0.531 -0.042
ENSG00000163491 E025 1.7747164 0.008220241 0.20066476 0.32703334 3 27202557 27202557 1 - 0.468 0.204 -1.690
ENSG00000163491 E026 0.0000000       3 27215607 27215731 125 -      
ENSG00000163491 E027 0.0000000       3 27215732 27215880 149 -      
ENSG00000163491 E028 0.0000000       3 27216370 27216475 106 -      
ENSG00000163491 E029 1.5658523 0.247432239 0.18285289 0.30476515 3 27255112 27255304 193 - 0.275 0.593 1.723
ENSG00000163491 E030 3.9963715 0.004569359 0.12155145 0.22214506 3 27256296 27256371 76 - 0.582 0.807 0.940
ENSG00000163491 E031 0.4513240 0.218171854 0.67288147 0.77872968 3 27278688 27278973 286 - 0.131 0.202 0.748
ENSG00000163491 E032 6.4887062 0.017219037 0.05754096 0.12240295 3 27284602 27284704 103 - 0.747 1.000 0.972
ENSG00000163491 E033 5.7159039 0.120832715 0.33005060 0.47364638 3 27284840 27284901 62 - 0.720 0.891 0.674
ENSG00000163491 E034 4.0308175 0.004155252 0.70386781 0.80248046 3 27284902 27284961 60 - 0.672 0.603 -0.300
ENSG00000163491 E035 3.4698097 0.004676871 0.25764120 0.39480260 3 27287698 27287743 46 - 0.656 0.448 -0.967
ENSG00000163491 E036 4.6081577 0.058862706 0.78046124 0.85891405 3 27290617 27290728 112 - 0.688 0.720 0.133
ENSG00000163491 E037 2.6988923 0.104429901 0.50918578 0.64452230 3 27290729 27290754 26 - 0.494 0.604 0.511
ENSG00000163491 E038 4.6929907 0.003855309 0.88689412 0.93167627 3 27291262 27291390 129 - 0.704 0.717 0.054
ENSG00000163491 E039 1.4727282 0.010419446 0.44574635 0.58728221 3 27291484 27291493 10 - 0.313 0.448 0.771
ENSG00000163491 E040 3.1012278 0.005134190 0.41718998 0.56056649 3 27291494 27291557 64 - 0.602 0.448 -0.732
ENSG00000163491 E041 3.4646129 0.004719919 0.08368796 0.16532601 3 27291558 27291586 29 - 0.672 0.343 -1.622
ENSG00000163491 E042 4.1664278 0.004065514 0.11038703 0.20610140 3 27293588 27293652 65 - 0.733 0.447 -1.290
ENSG00000163491 E043 4.3719653 0.021987525 0.53180306 0.66419875 3 27295613 27295690 78 - 0.718 0.602 -0.494
ENSG00000163491 E044 3.3118498 0.033657227 0.98240223 0.99304308 3 27297179 27297240 62 - 0.601 0.601 -0.002
ENSG00000163491 E045 4.8953205 0.003451141 0.43869781 0.58056465 3 27301696 27301835 140 - 0.704 0.807 0.415
ENSG00000163491 E046 5.1565076 0.004597977 0.78065210 0.85905922 3 27304747 27304971 225 - 0.733 0.764 0.127
ENSG00000163491 E047 3.3215166 0.004837350 0.10182993 0.19328485 3 27307859 27307945 87 - 0.656 0.343 -1.552
ENSG00000163491 E048 3.6723536 0.023670308 0.54046120 0.67161305 3 27308926 27309005 80 - 0.655 0.532 -0.549
ENSG00000163491 E049 0.0000000       3 27309157 27310948 1792 -      
ENSG00000163491 E050 3.5970115 0.015567443 0.51523750 0.64992010 3 27310949 27311016 68 - 0.655 0.532 -0.553
ENSG00000163491 E051 0.0000000       3 27311017 27312098 1082 -      
ENSG00000163491 E052 4.3481441 0.003783442 0.83319207 0.89548720 3 27312099 27312177 79 - 0.704 0.663 -0.170
ENSG00000163491 E053 4.3222216 0.003976255 0.49758838 0.63412167 3 27314297 27314338 42 - 0.718 0.602 -0.494
ENSG00000163491 E054 4.8768735 0.003837064 0.95033210 0.97291308 3 27322177 27322225 49 - 0.733 0.716 -0.067
ENSG00000163491 E055 3.9827582 0.016209059 0.71267627 0.80933200 3 27322226 27322261 36 - 0.672 0.602 -0.301
ENSG00000163491 E056 4.9738717 0.004160926 0.71451590 0.81069466 3 27344272 27344370 99 - 0.718 0.764 0.185
ENSG00000163491 E057 5.3737897 0.003274446 0.45285271 0.59365541 3 27346086 27346216 131 - 0.786 0.663 -0.503
ENSG00000163491 E058 4.3525003 0.003828537 0.02459344 0.06103961 3 27352465 27352525 61 - 0.760 0.343 -1.985
ENSG00000163491 E059 4.5060920 0.003615506 0.01982670 0.05111951 3 27352812 27352919 108 - 0.773 0.343 -2.037
ENSG00000163491 E060 0.0000000       3 27363687 27363844 158 -      
ENSG00000163491 E061 0.5954526 0.019387492 0.35644540 0.50081830 3 27367523 27367562 40 - 0.232 0.000 -11.509
ENSG00000163491 E062 0.0000000       3 27369031 27369196 166 -      
ENSG00000163491 E063 2.6540579 0.005782259 0.05076266 0.11052943 3 27369225 27369383 159 - 0.602 0.204 -2.318
ENSG00000163491 E064 0.1515154 0.044929401 1.00000000   3 27369384 27369392 9 - 0.071 0.000 -9.510
ENSG00000163491 E065 0.0000000       3 27369393 27369421 29 -      
ENSG00000163491 E066 0.0000000       3 27369422 27369460 39 -