ENSG00000163472

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295694 ENSG00000163472 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM79 protein_coding protein_coding 3.877466 5.374051 2.753576 0.2878843 0.1697525 -0.9621555 2.5009876 3.8553819 1.5871943 0.46210398 0.1541590 -1.2750712 0.63080833 0.71220000 0.58163333 -0.13056667 0.45331721 0.02114236 FALSE TRUE
ENST00000357501 ENSG00000163472 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM79 protein_coding protein_coding 3.877466 5.374051 2.753576 0.2878843 0.1697525 -0.9621555 0.2583330 0.4053911 0.2029873 0.40539113 0.2029873 -0.9637033 0.06326667 0.08426667 0.07396667 -0.01030000 0.98288378 0.02114236   TRUE
ENST00000463670 ENSG00000163472 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM79 protein_coding processed_transcript 3.877466 5.374051 2.753576 0.2878843 0.1697525 -0.9621555 0.2173128 0.4659804 0.1578828 0.23731460 0.1578828 -1.5034481 0.05245833 0.08260000 0.05173333 -0.03086667 0.71672756 0.02114236 FALSE TRUE
ENST00000495881 ENSG00000163472 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM79 protein_coding processed_transcript 3.877466 5.374051 2.753576 0.2878843 0.1697525 -0.9621555 0.5386005 0.4340426 0.5401149 0.05031945 0.1181809 0.3090349 0.14727500 0.08023333 0.19386667 0.11363333 0.02114236 0.02114236 TRUE TRUE
MSTRG.2357.1 ENSG00000163472 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM79 protein_coding   3.877466 5.374051 2.753576 0.2878843 0.1697525 -0.9621555 0.3607014 0.2132546 0.2653971 0.08369949 0.1126077 0.3028235 0.10573333 0.04070000 0.09880000 0.05810000 0.56552018 0.02114236 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163472 E001 0.6298062 0.0203188883 0.775246186 0.85519672 1 156282934 156282934 1 + 0.167 0.224 0.524
ENSG00000163472 E002 4.3686860 0.0051055897 0.766887347 0.84925445 1 156282935 156282947 13 + 0.718 0.684 -0.139
ENSG00000163472 E003 4.9598696 0.0036155063 0.924082216 0.95617738 1 156282948 156282952 5 + 0.718 0.741 0.095
ENSG00000163472 E004 16.9498063 0.0188291700 0.236241661 0.36982363 1 156282953 156283040 88 + 1.286 1.182 -0.367
ENSG00000163472 E005 18.4183778 0.0179825470 0.435124065 0.57735858 1 156283041 156283065 25 + 1.286 1.227 -0.207
ENSG00000163472 E006 0.4449813 0.0232258769 0.221437336 0.35213017 1 156284314 156284321 8 + 0.288 0.088 -2.059
ENSG00000163472 E007 0.4449813 0.0232258769 0.221437336 0.35213017 1 156284322 156284324 3 + 0.288 0.088 -2.059
ENSG00000163472 E008 0.7374030 0.0153787590 0.028363547 0.06873539 1 156284325 156284406 82 + 0.459 0.088 -3.058
ENSG00000163472 E009 28.0387601 0.0037596890 0.772146264 0.85292158 1 156285184 156285267 84 + 1.421 1.413 -0.027
ENSG00000163472 E010 43.2028175 0.0007621358 0.211687775 0.34047451 1 156285268 156285524 257 + 1.636 1.580 -0.191
ENSG00000163472 E011 41.0447651 0.0011122113 0.129277148 0.23317815 1 156285525 156285809 285 + 1.626 1.554 -0.249
ENSG00000163472 E012 27.4560079 0.0015198175 0.941243660 0.96706681 1 156285810 156285983 174 + 1.405 1.412 0.024
ENSG00000163472 E013 7.2265692 0.0024105632 0.005506135 0.01730373 1 156285984 156286259 276 + 1.072 0.759 -1.188
ENSG00000163472 E014 12.0873423 0.0061263740 0.410377169 0.55397014 1 156286260 156286275 16 + 0.996 1.098 0.369
ENSG00000163472 E015 37.2399019 0.0007144416 0.321904388 0.46518090 1 156286276 156286473 198 + 1.479 1.551 0.247
ENSG00000163472 E016 56.7296380 0.0012261514 0.604306470 0.72489456 1 156291385 156291664 280 + 1.685 1.722 0.126
ENSG00000163472 E017 22.9416635 0.0063835348 0.699124328 0.79894682 1 156291665 156291702 38 + 1.296 1.340 0.153
ENSG00000163472 E018 99.4442719 0.0128171599 0.031810344 0.07549009 1 156291703 156292443 741 + 1.854 1.990 0.460
ENSG00000163472 E019 4.7856553 0.0038523324 0.285660822 0.42601538 1 156292727 156293185 459 + 0.822 0.684 -0.555