ENSG00000163466

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315717 ENSG00000163466 HEK293_OSMI2_2hA HEK293_TMG_2hB ARPC2 protein_coding protein_coding 175.3901 198.5579 189.2765 18.10646 2.553421 -0.06906047 120.15005 148.51427 117.20597 18.411793 3.055123 -0.3415296 0.6820125 0.7440667 0.6190333 -0.1250333 0.01762909 0.0001845052 FALSE TRUE
MSTRG.19947.5 ENSG00000163466 HEK293_OSMI2_2hA HEK293_TMG_2hB ARPC2 protein_coding   175.3901 198.5579 189.2765 18.10646 2.553421 -0.06906047 47.54362 41.74057 64.55206 2.727979 1.396858 0.6288907 0.2715750 0.2145333 0.3412333 0.1267000 0.01497936 0.0001845052 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163466 E001 0.0000000       2 218216114 218216147 34 +      
ENSG00000163466 E002 0.0000000       2 218216148 218216817 670 +      
ENSG00000163466 E003 1.7327935 0.0093924058 3.590997e-01 5.034363e-01 2 218216818 218217140 323 + 0.320 0.483 0.905
ENSG00000163466 E004 0.8502072 0.0145591064 8.475592e-01 9.053302e-01 2 218217141 218217146 6 + 0.237 0.273 0.267
ENSG00000163466 E005 0.8502072 0.0145591064 8.475592e-01 9.053302e-01 2 218217147 218217148 2 + 0.237 0.273 0.267
ENSG00000163466 E006 82.0940274 0.0120216318 1.089559e-02 3.091414e-02 2 218217149 218217180 32 + 2.007 1.830 -0.595
ENSG00000163466 E007 133.2475227 0.0053678344 8.058338e-02 1.604663e-01 2 218217181 218217188 8 + 2.170 2.081 -0.295
ENSG00000163466 E008 150.5137383 0.0031846091 8.515246e-02 1.676544e-01 2 218217189 218217193 5 + 2.214 2.142 -0.241
ENSG00000163466 E009 163.3208086 0.0048164038 1.669683e-01 2.842630e-01 2 218217194 218217196 3 + 2.246 2.179 -0.222
ENSG00000163466 E010 246.4483855 0.0069376129 2.558553e-01 3.927928e-01 2 218217197 218217201 5 + 2.420 2.359 -0.204
ENSG00000163466 E011 272.9475962 0.0073338600 1.519444e-01 2.643070e-01 2 218217202 218217209 8 + 2.473 2.397 -0.253
ENSG00000163466 E012 461.2335845 0.0058807945 3.468443e-02 8.104470e-02 2 218217210 218217254 45 + 2.711 2.616 -0.317
ENSG00000163466 E013 3.2127065 0.0172016510 2.270593e-01 3.588858e-01 2 218217255 218217267 13 + 0.502 0.704 0.896
ENSG00000163466 E014 13.4554526 0.0015631324 2.152695e-01 3.447366e-01 2 218217268 218217371 104 + 1.089 1.208 0.426
ENSG00000163466 E015 26.0578285 0.0007574345 3.990706e-01 5.428189e-01 2 218217372 218217454 83 + 1.391 1.453 0.213
ENSG00000163466 E016 19.1136171 0.0009775388 9.676048e-01 9.837490e-01 2 218217455 218217462 8 + 1.299 1.300 0.003
ENSG00000163466 E017 747.8967565 0.0054201326 5.236752e-03 1.657567e-02 2 218217463 218217544 82 + 2.930 2.817 -0.375
ENSG00000163466 E018 5.7370305 0.0031858453 3.150700e-01 4.578260e-01 2 218225919 218225919 1 + 0.898 0.775 -0.479
ENSG00000163466 E019 732.4516435 0.0033196041 5.086575e-04 2.192026e-03 2 218225920 218225954 35 + 2.921 2.809 -0.372
ENSG00000163466 E020 0.4439371 0.0215629796 5.587012e-02 1.194662e-01 2 218226996 218227097 102 + 0.320 0.000 -10.461
ENSG00000163466 E021 905.9798976 0.0025353159 1.112715e-03 4.346132e-03 2 218228738 218228802 65 + 3.003 2.910 -0.306
ENSG00000163466 E022 803.4050315 0.0012066987 2.796833e-01 4.194472e-01 2 218228803 218228850 48 + 2.914 2.888 -0.085
ENSG00000163466 E023 4.2824742 0.0039420829 3.385887e-01 4.824709e-01 2 218228851 218229303 453 + 0.784 0.653 -0.540
ENSG00000163466 E024 5.6644200 0.0066446203 7.309807e-02 1.484862e-01 2 218233000 218234351 1352 + 0.936 0.706 -0.903
ENSG00000163466 E025 950.0041150 0.0004088556 7.049198e-01 8.033696e-01 2 218234352 218234397 46 + 2.976 2.971 -0.018
ENSG00000163466 E026 8.8313112 0.0025935781 8.151774e-04 3.313442e-03 2 218234398 218234848 451 + 1.160 0.796 -1.357
ENSG00000163466 E027 2.8140029 0.0058092425 4.340439e-03 1.409612e-02 2 218234849 218234859 11 + 0.784 0.336 -2.126
ENSG00000163466 E028 6.1657033 0.0030264372 9.062536e-03 2.643454e-02 2 218234860 218235044 185 + 1.004 0.680 -1.261
ENSG00000163466 E029 0.8825612 0.2920163478 6.020071e-01 7.230474e-01 2 218235045 218235052 8 + 0.320 0.205 -0.848
ENSG00000163466 E030 2.6300187 0.0064412498 2.332621e-01 3.662910e-01 2 218235196 218235340 145 + 0.666 0.482 -0.835
ENSG00000163466 E031 13.8521516 0.0018454413 2.758194e-07 2.571640e-06 2 218235341 218236368 1028 + 1.385 0.918 -1.675
ENSG00000163466 E032 5.9077264 0.0027540349 1.710477e-03 6.315061e-03 2 218236369 218236733 365 + 1.019 0.624 -1.559
ENSG00000163466 E033 1054.5807918 0.0011787819 9.139835e-01 9.495195e-01 2 218238664 218238718 55 + 3.016 3.018 0.005
ENSG00000163466 E034 1623.4937398 0.0002720381 3.886324e-01 5.327056e-01 2 218238719 218238850 132 + 3.199 3.211 0.038
ENSG00000163466 E035 13.4507062 0.0621964566 1.707233e-01 2.890970e-01 2 218238851 218239195 345 + 1.004 1.243 0.859
ENSG00000163466 E036 1427.6171718 0.0004957022 1.061615e-03 4.172091e-03 2 218239391 218239484 94 + 3.121 3.167 0.154
ENSG00000163466 E037 5.5260650 0.0029433945 9.878350e-01 9.964559e-01 2 218239485 218239562 78 + 0.810 0.815 0.022
ENSG00000163466 E038 837.3251525 0.0008815100 1.204893e-01 2.206616e-01 2 218245420 218245425 6 + 2.899 2.931 0.104
ENSG00000163466 E039 1809.9839776 0.0017341247 3.162128e-01 4.589680e-01 2 218245426 218245546 121 + 3.238 3.259 0.069
ENSG00000163466 E040 1745.5314694 0.0014902320 6.686531e-01 7.756061e-01 2 218249364 218249464 101 + 3.230 3.239 0.030
ENSG00000163466 E041 4.1994414 0.0850198947 9.244849e-01 9.564269e-01 2 218249592 218249820 229 + 0.698 0.742 0.180
ENSG00000163466 E042 1703.5762969 0.0015561499 3.324519e-01 4.761049e-01 2 218249821 218249921 101 + 3.213 3.232 0.065
ENSG00000163466 E043 1.1113933 0.1940683819 6.354147e-01 7.497207e-01 2 218250722 218250825 104 + 0.237 0.342 0.716
ENSG00000163466 E044 3.6480197 0.0043734315 2.349293e-03 8.305030e-03 2 218252945 218253032 88 + 0.320 0.815 2.342
ENSG00000163466 E045 1904.5333414 0.0013854118 1.383847e-08 1.662057e-07 2 218253891 218254411 521 + 3.207 3.312 0.349