ENSG00000163462

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334634 ENSG00000163462 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM46 protein_coding protein_coding 0.8627042 1.345047 0.3741684 0.02196235 0.05424129 -1.818532 0.40038900 0.90765727 0.175563119 0.157696529 0.087844904 -2.3060454 0.40492500 0.67133333 0.41740000 -0.25393333 0.61023039 0.03601036 FALSE TRUE
ENST00000368382 ENSG00000163462 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM46 protein_coding protein_coding 0.8627042 1.345047 0.3741684 0.02196235 0.05424129 -1.818532 0.07351015 0.09368962 0.000000000 0.093689617 0.000000000 -3.3741995 0.06739583 0.06933333 0.00000000 -0.06933333 0.95270520 0.03601036 FALSE TRUE
ENST00000368383 ENSG00000163462 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM46 protein_coding protein_coding 0.8627042 1.345047 0.3741684 0.02196235 0.05424129 -1.818532 0.01950045 0.02725271 0.008343626 0.027252707 0.008343626 -1.0220664 0.05602917 0.01976667 0.03026667 0.01050000 0.88190204 0.03601036 FALSE TRUE
ENST00000368385 ENSG00000163462 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM46 protein_coding protein_coding 0.8627042 1.345047 0.3741684 0.02196235 0.05424129 -1.818532 0.04896319 0.09143853 0.000000000 0.007431948 0.000000000 -3.3425338 0.05263750 0.06816667 0.00000000 -0.06816667 0.30084163 0.03601036 FALSE TRUE
ENST00000468878 ENSG00000163462 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM46 protein_coding processed_transcript 0.8627042 1.345047 0.3741684 0.02196235 0.05424129 -1.818532 0.05944155 0.11172330 0.000000000 0.084159936 0.000000000 -3.6055334 0.05322917 0.08483333 0.00000000 -0.08483333 0.62930969 0.03601036 TRUE TRUE
ENST00000474430 ENSG00000163462 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM46 protein_coding processed_transcript 0.8627042 1.345047 0.3741684 0.02196235 0.05424129 -1.818532 0.08131734 0.02105613 0.106714488 0.010545592 0.056773465 1.9100338 0.10262500 0.01586667 0.24926667 0.23340000 0.03601036 0.03601036 TRUE TRUE
ENST00000545012 ENSG00000163462 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM46 protein_coding protein_coding 0.8627042 1.345047 0.3741684 0.02196235 0.05424129 -1.818532 0.05773585 0.09222917 0.083547136 0.092229172 0.083547136 -0.1280416 0.10051250 0.07070000 0.30306667 0.23236667 0.90442561 0.03601036 FALSE TRUE
ENST00000611379 ENSG00000163462 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM46 protein_coding protein_coding 0.8627042 1.345047 0.3741684 0.02196235 0.05424129 -1.818532 0.09543779 0.00000000 0.000000000 0.000000000 0.000000000 0.0000000 0.12727500 0.00000000 0.00000000 0.00000000   0.03601036 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163462 E001 0.1817044 0.041267387 1.000000000   1 155173787 155173848 62 + 0.000 0.067 8.372
ENSG00000163462 E002 0.8846626 0.014718319 1.000000000 1.00000000 1 155173849 155173877 29 + 0.214 0.222 0.066
ENSG00000163462 E003 1.0663669 0.013920708 0.867361820 0.91870744 1 155173878 155173890 13 + 0.214 0.263 0.388
ENSG00000163462 E004 1.2146601 0.011722082 0.718042205 0.81326247 1 155173891 155173899 9 + 0.214 0.301 0.650
ENSG00000163462 E005 1.2146601 0.011722082 0.718042205 0.81326247 1 155173900 155173908 9 + 0.214 0.301 0.650
ENSG00000163462 E006 3.6597627 0.005162560 0.390203946 0.53420003 1 155173909 155174029 121 + 0.683 0.564 -0.521
ENSG00000163462 E007 0.1482932 0.044827425 1.000000000   1 155174030 155174039 10 + 0.000 0.067 10.278
ENSG00000163462 E008 0.1817044 0.041267387 1.000000000   1 155174601 155174641 41 + 0.000 0.067 10.284
ENSG00000163462 E009 0.0000000       1 155174754 155174837 84 +      
ENSG00000163462 E010 0.0000000       1 155174838 155174968 131 +      
ENSG00000163462 E011 0.1451727 0.046406887 0.103257893   1 155175186 155175272 87 + 0.214 0.000 -13.804
ENSG00000163462 E012 6.5339494 0.003494030 0.895492259 0.93722659 1 155175386 155175647 262 + 0.785 0.789 0.018
ENSG00000163462 E013 7.9303906 0.002278214 0.176750266 0.29701474 1 155175888 155176231 344 + 0.967 0.823 -0.548
ENSG00000163462 E014 6.1925021 0.002749156 0.025126724 0.06213851 1 155176932 155177075 144 + 0.967 0.698 -1.050
ENSG00000163462 E015 5.5542597 0.005839998 0.960878862 0.97936009 1 155177195 155177290 96 + 0.683 0.713 0.127
ENSG00000163462 E016 7.9438141 0.002802607 0.669114297 0.77599858 1 155178002 155178255 254 + 0.867 0.835 -0.126
ENSG00000163462 E017 6.3646375 0.002908409 0.633291535 0.74801225 1 155178492 155178613 122 + 0.683 0.778 0.388
ENSG00000163462 E018 1.3953203 0.012465594 0.717868603 0.81313260 1 155178809 155178846 38 + 0.357 0.301 -0.349
ENSG00000163462 E019 11.0654965 0.004503253 0.852882911 0.90884006 1 155179632 155179934 303 + 0.967 0.970 0.011
ENSG00000163462 E020 0.1817044 0.041267387 1.000000000   1 155179935 155179935 1 + 0.000 0.067 10.284
ENSG00000163462 E021 1.2511787 0.010881643 0.164761280 0.28138296 1 155180435 155180621 187 + 0.000 0.335 12.622
ENSG00000163462 E022 10.8504060 0.001992624 0.682639970 0.78604525 1 155181852 155182149 298 + 0.903 0.977 0.279
ENSG00000163462 E023 2.5926674 0.013190990 0.004671456 0.01501567 1 155182150 155182862 713 + 0.785 0.336 -2.123
ENSG00000163462 E024 39.4651537 0.024579480 0.035844678 0.08328326 1 155183797 155184971 1175 + 1.317 1.526 0.722