ENSG00000163430

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295633 ENSG00000163430 HEK293_OSMI2_2hA HEK293_TMG_2hB FSTL1 protein_coding protein_coding 61.99806 25.71801 112.2998 3.30833 4.574555 2.126072 25.213786 17.6553375 39.389304 2.60331292 0.9806294 1.157249 0.4879083 0.68963333 0.3525333 -0.337100000 0.0001465576 1.242644e-10 FALSE TRUE
ENST00000424703 ENSG00000163430 HEK293_OSMI2_2hA HEK293_TMG_2hB FSTL1 protein_coding protein_coding 61.99806 25.71801 112.2998 3.30833 4.574555 2.126072 15.691163 0.4278361 34.679227 0.42783614 1.5798112 6.307953 0.1851375 0.01506667 0.3089667 0.293900000 0.0107086144 1.242644e-10 FALSE TRUE
ENST00000469005 ENSG00000163430 HEK293_OSMI2_2hA HEK293_TMG_2hB FSTL1 protein_coding protein_coding 61.99806 25.71801 112.2998 3.30833 4.574555 2.126072 4.356361 0.5280867 8.642137 0.09119679 3.2442556 4.007146 0.0492625 0.02183333 0.0750000 0.053166667 0.0738295211 1.242644e-10 FALSE FALSE
ENST00000637333 ENSG00000163430 HEK293_OSMI2_2hA HEK293_TMG_2hB FSTL1 protein_coding miRNA 61.99806 25.71801 112.2998 3.30833 4.574555 2.126072 14.305285 5.4336200 24.545664 1.03438654 0.1832119 2.173418 0.2330042 0.21086667 0.2192333 0.008366667 0.9191793018 1.242644e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163430 E001 2316.865211 0.0046578483 9.485540e-18 4.678488e-16 3 120392293 120395667 3375 - 3.211 3.510 0.994
ENSG00000163430 E002 727.334314 0.0007706462 1.728337e-06 1.363262e-05 3 120395668 120396222 555 - 2.758 2.934 0.588
ENSG00000163430 E003 361.181476 0.0003623960 2.037656e-02 5.227543e-02 3 120396223 120396472 250 - 2.466 2.608 0.472
ENSG00000163430 E004 640.074646 0.0010385533 3.245468e-02 7.672428e-02 3 120396473 120396890 418 - 2.745 2.787 0.140
ENSG00000163430 E005 331.727348 0.0007698943 3.508794e-04 1.583672e-03 3 120396891 120396973 83 - 2.472 2.472 0.000
ENSG00000163430 E006 265.803542 0.0008880689 2.054623e-05 1.271119e-04 3 120396974 120396996 23 - 2.384 2.354 -0.098
ENSG00000163430 E007 345.269483 0.0002005212 4.269993e-07 3.829108e-06 3 120399883 120399959 77 - 2.495 2.475 -0.063
ENSG00000163430 E008 2.927551 0.3869027406 3.601342e-01 5.044461e-01 3 120399960 120400089 130 - 0.603 0.351 -1.278
ENSG00000163430 E009 429.496529 0.0006491765 1.549172e-06 1.234327e-05 3 120402808 120402918 111 - 2.588 2.571 -0.058
ENSG00000163430 E010 407.524813 0.0001469621 2.106481e-13 5.718271e-12 3 120403242 120403354 113 - 2.576 2.519 -0.189
ENSG00000163430 E011 290.677160 0.0002223160 6.945646e-12 1.485473e-10 3 120404853 120404894 42 - 2.434 2.358 -0.253
ENSG00000163430 E012 309.676357 0.0001508926 4.970214e-12 1.087666e-10 3 120404895 120404971 77 - 2.460 2.391 -0.229
ENSG00000163430 E013 283.636867 0.0002939779 3.673007e-13 9.640346e-12 3 120409532 120409574 43 - 2.427 2.335 -0.306
ENSG00000163430 E014 339.786604 0.0004757260 6.250570e-15 2.123277e-13 3 120409575 120409662 88 - 2.507 2.408 -0.329
ENSG00000163430 E015 1.258759 0.0110093292 3.230717e-01 4.664053e-01 3 120409957 120410951 995 - 0.352 0.203 -1.071
ENSG00000163430 E016 250.802511 0.0010611131 2.253199e-13 6.097155e-12 3 120410952 120410984 33 - 2.382 2.246 -0.455
ENSG00000163430 E017 5.089824 0.3022163653 8.319260e-01 8.946848e-01 3 120410985 120411326 342 - 0.709 0.811 0.408
ENSG00000163430 E018 360.352961 0.0001751355 2.647907e-21 1.962590e-19 3 120411854 120411983 130 - 2.537 2.418 -0.397
ENSG00000163430 E019 279.941253 0.0014791198 9.483462e-10 1.411988e-08 3 120415923 120416027 105 - 2.422 2.322 -0.334
ENSG00000163430 E020 4.934790 0.0033010878 1.654781e-06 1.310098e-05 3 120421172 120421552 381 - 0.416 1.128 2.951
ENSG00000163430 E021 5.748960 0.0864912559 1.070362e-01 2.011615e-01 3 120423527 120424076 550 - 0.660 1.000 1.333
ENSG00000163430 E022 4.402099 0.0327665853 2.016623e-03 7.278122e-03 3 120438261 120438458 198 - 0.472 1.019 2.267
ENSG00000163430 E023 3.950777 0.2406190782 2.601475e-01 3.976325e-01 3 120441268 120441404 137 - 0.520 0.902 1.594
ENSG00000163430 E024 175.227409 0.0014582425 1.132313e-06 9.293534e-06 3 120450684 120450746 63 - 2.217 2.133 -0.284
ENSG00000163430 E025 10.495753 0.0155448996 4.136541e-01 5.570956e-01 3 120450747 120450797 51 - 1.020 0.995 -0.090
ENSG00000163430 E026 151.718095 0.0074448839 4.082925e-03 1.337514e-02 3 120450897 120450993 97 - 2.151 2.078 -0.245