ENSG00000163349

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361587 ENSG00000163349 HEK293_OSMI2_2hA HEK293_TMG_2hB HIPK1 protein_coding protein_coding 11.93999 7.062529 16.48688 1.194787 0.06763882 1.221895 1.7523989 4.1770476 0.0000000 1.1408480 0.0000000 -8.7097895 0.25622917 0.5750333 0.00000000 -0.57503333 4.232989e-24 4.232989e-24 FALSE TRUE
ENST00000369553 ENSG00000163349 HEK293_OSMI2_2hA HEK293_TMG_2hB HIPK1 protein_coding protein_coding 11.93999 7.062529 16.48688 1.194787 0.06763882 1.221895 0.4848591 0.8912938 0.0000000 0.0864746 0.0000000 -6.4939255 0.04490833 0.1333000 0.00000000 -0.13330000 1.298906e-15 4.232989e-24 FALSE TRUE
ENST00000369558 ENSG00000163349 HEK293_OSMI2_2hA HEK293_TMG_2hB HIPK1 protein_coding protein_coding 11.93999 7.062529 16.48688 1.194787 0.06763882 1.221895 6.7936718 0.1784842 11.9246043 0.1367577 0.4188207 5.9845631 0.45118750 0.0284000 0.72350000 0.69510000 1.346371e-06 4.232989e-24 FALSE TRUE
MSTRG.1856.4 ENSG00000163349 HEK293_OSMI2_2hA HEK293_TMG_2hB HIPK1 protein_coding   11.93999 7.062529 16.48688 1.194787 0.06763882 1.221895 0.1989198 0.0000000 0.8934233 0.0000000 0.6101199 6.4973302 0.01135417 0.0000000 0.05393333 0.05393333 3.325830e-01 4.232989e-24 FALSE TRUE
MSTRG.1856.9 ENSG00000163349 HEK293_OSMI2_2hA HEK293_TMG_2hB HIPK1 protein_coding   11.93999 7.062529 16.48688 1.194787 0.06763882 1.221895 0.7513523 1.6618244 1.1447573 0.1333157 0.7218881 -0.5338337 0.09950417 0.2422667 0.06923333 -0.17303333 3.401862e-01 4.232989e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163349 E001 0.5891098 0.0183520678 2.763680e-01 4.158195e-01 1 113929324 113929373 50 + 0.196 0.000 -18.964
ENSG00000163349 E002 0.5891098 0.0183520678 2.763680e-01 4.158195e-01 1 113929374 113929532 159 + 0.196 0.000 -18.959
ENSG00000163349 E003 1.0987104 0.0742207970 5.163988e-01 6.509820e-01 1 113929659 113929709 51 + 0.268 0.242 -0.199
ENSG00000163349 E004 0.9535377 0.0595823282 6.386312e-01 7.522229e-01 1 113929710 113929754 45 + 0.234 0.242 0.062
ENSG00000163349 E005 0.8168978 0.0142147102 7.898271e-01 8.655558e-01 1 113929755 113929816 62 + 0.196 0.241 0.378
ENSG00000163349 E006 1.2608349 0.0098763096 3.671775e-01 5.115621e-01 1 113929817 113929822 6 + 0.301 0.241 -0.430
ENSG00000163349 E007 9.1647306 0.0017693233 5.186444e-04 2.229738e-03 1 113929823 113929858 36 + 0.954 0.673 -1.109
ENSG00000163349 E008 27.8419083 0.0006855777 4.580385e-09 6.015496e-08 1 113929859 113929939 81 + 1.400 1.109 -1.024
ENSG00000163349 E009 0.0000000       1 113930505 113930624 120 +      
ENSG00000163349 E010 0.0000000       1 113930728 113930859 132 +      
ENSG00000163349 E011 0.0000000       1 113932201 113932222 22 +      
ENSG00000163349 E012 0.7427016 0.0156043985 1.838210e-01 3.060107e-01 1 113933140 113933234 95 + 0.234 0.000 -19.281
ENSG00000163349 E013 57.2140508 0.0004512389 2.006529e-12 4.683144e-11 1 113940382 113940566 185 + 1.691 1.507 -0.628
ENSG00000163349 E014 132.5579226 0.0003758556 5.587326e-23 4.946272e-21 1 113940567 113941085 519 + 2.047 1.901 -0.491
ENSG00000163349 E015 133.2595797 0.0002751780 1.521080e-23 1.430095e-21 1 113941086 113941459 374 + 2.049 1.901 -0.496
ENSG00000163349 E016 0.1482932 0.0411597534 1.596343e-01   1 113951145 113951292 148 + 0.000 0.240 21.433
ENSG00000163349 E017 81.5878474 0.0027610940 5.807245e-10 9.001515e-09 1 113952766 113952889 124 + 1.830 1.729 -0.342
ENSG00000163349 E018 0.2987644 0.0273636117 7.285048e-01   1 113953877 113953932 56 + 0.109 0.000 -17.959
ENSG00000163349 E019 0.4396707 0.0273805105 4.324095e-01 5.748599e-01 1 113954626 113954650 25 + 0.155 0.000 -18.543
ENSG00000163349 E020 82.0178187 0.0007812416 8.454604e-09 1.056042e-07 1 113954651 113954770 120 + 1.821 1.786 -0.120
ENSG00000163349 E021 81.2471845 0.0010443650 2.213507e-06 1.704990e-05 1 113955563 113955649 87 + 1.809 1.826 0.057
ENSG00000163349 E022 98.8952481 0.0003973870 9.218414e-07 7.709358e-06 1 113956627 113956811 185 + 1.890 1.932 0.142
ENSG00000163349 E023 52.5200743 0.0017687842 3.438199e-07 3.143006e-06 1 113957124 113957184 61 + 1.641 1.563 -0.264
ENSG00000163349 E024 64.9659053 0.0007598702 1.466119e-02 3.972934e-02 1 113957185 113957286 102 + 1.691 1.816 0.422
ENSG00000163349 E025 101.2503434 0.0003017684 2.598433e-06 1.972612e-05 1 113958066 113958291 226 + 1.895 1.950 0.186
ENSG00000163349 E026 75.4460376 0.0008956316 6.314118e-07 5.475059e-06 1 113962317 113962438 122 + 1.780 1.775 -0.017
ENSG00000163349 E027 51.4385275 0.0008305725 3.132048e-05 1.855011e-04 1 113963387 113963439 53 + 1.617 1.613 -0.013
ENSG00000163349 E028 50.6482734 0.0005516139 1.358098e-05 8.747709e-05 1 113963440 113963521 82 + 1.613 1.597 -0.052
ENSG00000163349 E029 21.7316714 0.0080499034 2.931069e-02 7.060796e-02 1 113966130 113966132 3 + 1.252 1.274 0.079
ENSG00000163349 E030 70.7290574 0.0250284409 1.354398e-01 2.417241e-01 1 113966133 113966272 140 + 1.731 1.825 0.318
ENSG00000163349 E031 99.7075342 0.0093151668 7.298777e-03 2.199770e-02 1 113967766 113967948 183 + 1.884 1.954 0.234
ENSG00000163349 E032 125.3761719 0.0141736503 1.131017e-02 3.190549e-02 1 113968442 113968648 207 + 1.984 2.045 0.206
ENSG00000163349 E033 123.4775258 0.0039151015 8.821927e-05 4.666055e-04 1 113969956 113970197 242 + 1.979 2.033 0.181
ENSG00000163349 E034 55.4983512 0.0004678853 6.702401e-05 3.657429e-04 1 113971824 113971898 75 + 1.643 1.665 0.074
ENSG00000163349 E035 49.2603311 0.0004582004 1.274931e-03 4.893667e-03 1 113971899 113971954 56 + 1.586 1.644 0.195
ENSG00000163349 E036 0.4481018 0.0367545912 1.468667e-01 2.574172e-01 1 113971955 113972073 119 + 0.058 0.394 3.370
ENSG00000163349 E037 1478.8636637 0.0220981142 1.193768e-09 1.743415e-08 1 113973024 113977869 4846 + 2.929 3.397 1.558