ENSG00000163297

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307333 ENSG00000163297 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR2 protein_coding protein_coding 2.176761 1.319381 3.4436 0.06396888 0.1659466 1.377346 0.08262303 0.00000000 0.22183086 0.00000000 0.221830864 4.535001 0.02427917 0.00000000 0.05973333 0.05973333 0.9626723570 0.0001412487 FALSE TRUE
ENST00000403729 ENSG00000163297 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR2 protein_coding protein_coding 2.176761 1.319381 3.4436 0.06396888 0.1659466 1.377346 0.12248963 0.07437759 0.22066031 0.01132436 0.009822484 1.450838 0.05201250 0.05653333 0.06463333 0.00810000 0.9717795457 0.0001412487 FALSE TRUE
ENST00000449651 ENSG00000163297 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR2 protein_coding nonsense_mediated_decay 2.176761 1.319381 3.4436 0.06396888 0.1659466 1.377346 0.03984512 0.16535412 0.00000000 0.16535412 0.000000000 -4.132199 0.02944167 0.11733333 0.00000000 -0.11733333 0.5905519688 0.0001412487 TRUE TRUE
ENST00000680913 ENSG00000163297 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR2 protein_coding protein_coding 2.176761 1.319381 3.4436 0.06396888 0.1659466 1.377346 0.33504030 0.27095023 0.08567677 0.14077258 0.085676774 -1.554074 0.17414167 0.21223333 0.02306667 -0.18916667 0.3617384006 0.0001412487 FALSE TRUE
ENST00000681115 ENSG00000163297 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR2 protein_coding protein_coding 2.176761 1.319381 3.4436 0.06396888 0.1659466 1.377346 0.33221420 0.00000000 0.70943505 0.00000000 0.183681392 6.168793 0.15590000 0.00000000 0.20793333 0.20793333 0.0001412487 0.0001412487 FALSE TRUE
ENST00000681710 ENSG00000163297 HEK293_OSMI2_2hA HEK293_TMG_2hB ANTXR2 protein_coding protein_coding 2.176761 1.319381 3.4436 0.06396888 0.1659466 1.377346 1.17276446 0.75671718 2.07610475 0.17676214 0.119368749 1.444045 0.52510833 0.57550000 0.60906667 0.03356667 0.9254163423 0.0001412487 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163297 E001 14.8551949 0.0013175034 5.380426e-01 6.695078e-01 4 79901146 79905570 4425 - 1.195 1.139 -0.197
ENSG00000163297 E002 1.7693015 0.0088817964 3.074954e-01 4.497239e-01 4 79905571 79905590 20 - 0.360 0.539 0.926
ENSG00000163297 E003 2.9568801 0.0074269140 8.906265e-03 2.604769e-02 4 79905591 79905605 15 - 0.399 0.806 1.841
ENSG00000163297 E004 2.8117074 0.0461473969 1.139372e-02 3.210390e-02 4 79905606 79905612 7 - 0.360 0.805 2.057
ENSG00000163297 E005 42.6442704 0.0009926936 2.049787e-08 2.385295e-07 4 79905613 79906172 560 - 1.494 1.788 1.003
ENSG00000163297 E006 34.0631378 0.0008021709 1.643944e-01 2.809007e-01 4 79906173 79906761 589 - 1.488 1.573 0.292
ENSG00000163297 E007 35.9301402 0.0007356695 9.955130e-01 1.000000e+00 4 79906762 79907169 408 - 1.542 1.543 0.004
ENSG00000163297 E008 18.8419895 0.0010689643 6.341315e-01 7.486916e-01 4 79907170 79907352 183 - 1.286 1.248 -0.132
ENSG00000163297 E009 10.3346112 0.0123153455 5.903031e-01 7.131816e-01 4 79907353 79907404 52 - 1.055 0.993 -0.227
ENSG00000163297 E010 11.0837536 0.0241120556 9.261119e-01 9.574723e-01 4 79907405 79907467 63 - 1.063 1.054 -0.034
ENSG00000163297 E011 0.0000000       4 79907577 79907664 88 -      
ENSG00000163297 E012 0.0000000       4 79920071 79920121 51 -      
ENSG00000163297 E013 0.2214452 0.0398082489 2.115358e-01   4 79964665 79964838 174 - 0.000 0.174 11.527
ENSG00000163297 E014 0.2214452 0.0398082489 2.115358e-01   4 79964839 79965097 259 - 0.000 0.174 11.527
ENSG00000163297 E015 0.7353121 0.1404098514 4.480019e-01 5.893481e-01 4 79977537 79977578 42 - 0.155 0.301 1.219
ENSG00000163297 E016 0.8825612 0.1623001088 6.725566e-01 7.784965e-01 4 79977579 79977620 42 - 0.216 0.302 0.638
ENSG00000163297 E017 13.2849864 0.0013165236 8.741914e-01 9.231130e-01 4 79977621 79977701 81 - 1.137 1.124 -0.049
ENSG00000163297 E018 19.3675613 0.0021255060 6.649264e-01 7.726743e-01 4 79978007 79978174 168 - 1.305 1.271 -0.117
ENSG00000163297 E019 12.1217815 0.0167352400 8.997142e-01 9.400250e-01 4 79983878 79983970 93 - 1.101 1.120 0.068
ENSG00000163297 E020 8.7710976 0.0786805589 8.799928e-01 9.270430e-01 4 79984819 79984863 45 - 0.982 0.980 -0.009
ENSG00000163297 E021 14.8304939 0.0020792897 7.081631e-01 8.058733e-01 4 80008521 80008616 96 - 1.200 1.169 -0.113
ENSG00000163297 E022 14.3532353 0.0013627272 2.785228e-01 4.181981e-01 4 80018898 80018976 79 - 1.206 1.107 -0.355
ENSG00000163297 E023 0.0000000       4 80024637 80024755 119 -      
ENSG00000163297 E024 13.5964563 0.0137562209 6.481233e-02 1.347346e-01 4 80031623 80031692 70 - 1.212 1.012 -0.722
ENSG00000163297 E025 16.6859145 0.0011342524 4.451295e-02 9.930574e-02 4 80033472 80033570 99 - 1.286 1.107 -0.635
ENSG00000163297 E026 13.9356241 0.0013389220 1.979579e-01 3.236716e-01 4 80035972 80036032 61 - 1.195 1.072 -0.438
ENSG00000163297 E027 7.0616469 0.0187617433 3.720720e-01 5.165464e-01 4 80054272 80054280 9 - 0.931 0.806 -0.481
ENSG00000163297 E028 10.5055421 0.0032762936 7.001274e-01 7.996575e-01 4 80054281 80054352 72 - 1.055 1.014 -0.147
ENSG00000163297 E029 16.2522102 0.0013921276 3.734819e-01 5.179221e-01 4 80055150 80055218 69 - 1.182 1.260 0.276
ENSG00000163297 E030 19.4034758 0.0010212268 7.549372e-01 8.404324e-01 4 80055360 80055467 108 - 1.295 1.272 -0.083
ENSG00000163297 E031 15.9099137 0.0011850181 1.135229e-01 2.106587e-01 4 80055932 80056013 82 - 1.251 1.107 -0.510
ENSG00000163297 E032 10.6329994 0.0016478081 1.010639e-01 1.920868e-01 4 80069436 80069507 72 - 1.102 0.923 -0.658
ENSG00000163297 E033 10.1440214 0.0027168761 4.406199e-01 5.823017e-01 4 80071583 80071654 72 - 1.055 0.971 -0.308
ENSG00000163297 E034 11.2684549 0.0315852369 4.387077e-01 5.805647e-01 4 80072409 80072708 300 - 1.108 1.010 -0.358
ENSG00000163297 E035 15.0770686 0.0033195622 1.645912e-01 2.811456e-01 4 80072709 80073229 521 - 1.223 1.091 -0.475
ENSG00000163297 E036 0.0000000       4 80073395 80073472 78 -      
ENSG00000163297 E037 0.0000000       4 80079353 80079600 248 -      
ENSG00000163297 E038 0.0000000       4 80097500 80097629 130 -      
ENSG00000163297 E039 0.0000000       4 80097737 80097961 225 -      
ENSG00000163297 E040 0.0000000       4 80104463 80104537 75 -      
ENSG00000163297 E041 0.0000000       4 80121148 80121277 130 -      
ENSG00000163297 E042 0.0000000       4 80125386 80125454 69 -