ENSG00000163291

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395594 ENSG00000163291 HEK293_OSMI2_2hA HEK293_TMG_2hB PAQR3 protein_coding nonsense_mediated_decay 16.75931 5.137913 24.14309 0.5584318 1.08232 2.230148 4.6705828 0.9262021 7.5318161 0.26967439 0.5114776 3.0100201 0.2303292 0.1738333 0.31260000 0.1387667 5.874495e-02 2.462357e-12 TRUE TRUE
ENST00000503343 ENSG00000163291 HEK293_OSMI2_2hA HEK293_TMG_2hB PAQR3 protein_coding processed_transcript 16.75931 5.137913 24.14309 0.5584318 1.08232 2.230148 1.0044167 1.0433388 0.9043415 0.32298895 0.2799000 -0.2041646 0.1143917 0.1951000 0.03673333 -0.1583667 5.845937e-04 2.462357e-12 FALSE FALSE
ENST00000511594 ENSG00000163291 HEK293_OSMI2_2hA HEK293_TMG_2hB PAQR3 protein_coding nonsense_mediated_decay 16.75931 5.137913 24.14309 0.5584318 1.08232 2.230148 1.0988737 0.7563773 1.0643721 0.14400672 0.1062862 0.4873670 0.1022958 0.1506000 0.04433333 -0.1062667 1.426133e-03 2.462357e-12 TRUE TRUE
ENST00000515541 ENSG00000163291 HEK293_OSMI2_2hA HEK293_TMG_2hB PAQR3 protein_coding processed_transcript 16.75931 5.137913 24.14309 0.5584318 1.08232 2.230148 0.1512055 0.3286643 0.0000000 0.06232837 0.0000000 -5.0817842 0.0261000 0.0649000 0.00000000 -0.0649000 2.462357e-12 2.462357e-12 FALSE FALSE
ENST00000515853 ENSG00000163291 HEK293_OSMI2_2hA HEK293_TMG_2hB PAQR3 protein_coding nonsense_mediated_decay 16.75931 5.137913 24.14309 0.5584318 1.08232 2.230148 8.6277799 1.9197421 13.1072401 0.08164159 0.6702689 2.7649843 0.4508250 0.3806667 0.54320000 0.1625333 1.706132e-02 2.462357e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163291 E001 0.2998086 0.0281121409 2.130469e-01   4 78887127 78887309 183 - 0.055 0.250 2.524
ENSG00000163291 E002 0.0000000       4 78888061 78888148 88 -      
ENSG00000163291 E003 0.6664265 0.0172671820 1.048732e-01 1.979034e-01 4 78906108 78906161 54 - 0.104 0.409 2.527
ENSG00000163291 E004 23.3512927 0.0010151481 1.289049e-38 4.090562e-36 4 78910838 78911877 1040 - 0.891 1.853 3.374
ENSG00000163291 E005 9.5652605 0.0092428595 1.706561e-11 3.419746e-10 4 78911878 78912063 186 - 0.656 1.427 2.865
ENSG00000163291 E006 1.9366374 0.2103219974 2.153472e-01 3.448303e-01 4 78912064 78913958 1895 - 0.320 0.675 1.778
ENSG00000163291 E007 2.4315779 0.0421306926 3.535624e-01 4.978138e-01 4 78913959 78914808 850 - 0.419 0.614 0.937
ENSG00000163291 E008 3.7107530 0.0431134896 6.802327e-07 5.855509e-06 4 78914809 78915197 389 - 0.290 1.104 3.627
ENSG00000163291 E009 2.2757049 0.0259123486 7.918770e-05 4.240332e-04 4 78915198 78915209 12 - 0.225 0.904 3.371
ENSG00000163291 E010 9.4470309 0.0018720113 8.525889e-12 1.796468e-10 4 78915210 78915370 161 - 0.668 1.415 2.770
ENSG00000163291 E011 2.2111634 0.0083655298 5.444782e-01 6.749534e-01 4 78915371 78917760 2390 - 0.396 0.524 0.653
ENSG00000163291 E012 16.4606245 0.0017534594 3.868135e-20 2.506178e-18 4 78917761 78917880 120 - 0.860 1.658 2.833
ENSG00000163291 E013 0.4804688 0.0222342845 4.054749e-01 5.491643e-01 4 78917881 78917899 19 - 0.104 0.251 1.527
ENSG00000163291 E014 0.0000000       4 78917900 78917939 40 -      
ENSG00000163291 E015 0.2965864 0.0545896260 1.167356e-02   4 78917940 78917941 2 - 0.000 0.407 12.410
ENSG00000163291 E016 731.0322994 0.0011111163 3.796792e-02 8.728833e-02 4 78917942 78920533 2592 - 2.737 2.786 0.165
ENSG00000163291 E017 107.2773660 0.0006692727 1.913817e-11 3.805277e-10 4 78920534 78920681 148 - 1.959 1.603 -1.203
ENSG00000163291 E018 6.9277569 0.0024523602 1.806940e-02 4.727906e-02 4 78922141 78922421 281 - 0.843 0.409 -1.933
ENSG00000163291 E019 1.6713740 0.0088270091 5.534176e-01 6.825744e-01 4 78922829 78922983 155 - 0.372 0.251 -0.796
ENSG00000163291 E020 1.8732393 0.0366583228 5.102134e-01 6.454522e-01 4 78923517 78923856 340 - 0.397 0.251 -0.932
ENSG00000163291 E021 91.2639652 0.0016824537 8.133947e-02 1.616507e-01 4 78923857 78923916 60 - 1.859 1.781 -0.263
ENSG00000163291 E022 87.3896074 0.0028047681 5.089467e-02 1.107608e-01 4 78923917 78923947 31 - 1.843 1.745 -0.330
ENSG00000163291 E023 111.6520280 0.0003262269 2.816855e-02 6.834335e-02 4 78926521 78926599 79 - 1.946 1.862 -0.281
ENSG00000163291 E024 106.7298394 0.0002901419 1.054875e-02 3.008942e-02 4 78926600 78926673 74 - 1.932 1.828 -0.348
ENSG00000163291 E025 82.5278569 0.0003818416 4.155068e-02 9.390913e-02 4 78926674 78926718 45 - 1.819 1.727 -0.312
ENSG00000163291 E026 123.5856742 0.0002658994 2.311638e-01 3.638585e-01 4 78930170 78930325 156 - 1.984 1.951 -0.111
ENSG00000163291 E027 1.1072432 0.0115387929 1.000000e+00 1.000000e+00 4 78930326 78930620 295 - 0.258 0.251 -0.057
ENSG00000163291 E028 1.3620004 0.0096765512 7.341578e-01 8.251843e-01 4 78933076 78933231 156 - 0.319 0.251 -0.473
ENSG00000163291 E029 69.3589939 0.0003717148 1.446638e-01 2.543727e-01 4 78935121 78935176 56 - 1.740 1.673 -0.228
ENSG00000163291 E030 77.5471081 0.0020682833 1.676688e-02 4.442377e-02 4 78935177 78935283 107 - 1.798 1.672 -0.426
ENSG00000163291 E031 97.1090823 0.0003490102 1.428983e-04 7.161246e-04 4 78939040 78939438 399 - 1.900 1.721 -0.607